| Sparkshift Limited | Professional & scientific | 2025 |
| SPB Cladding Ltd | Construction | 2023 |
| SPC Limited | Hospitality | 2024 |
| SPC Plym Ltd | Real estate | 2025 |
| Special Health Limited | Health & social care | 2022 |
| Specialist KIT Limited | Wholesale & retail | 2015 |
| Specialist Medical Support Ltd | Administrative & support | 2014 |
| Specialist Scaffolding Contractors Limited | Construction | 2025 |
| Specialist Vehicles of Plymouth Limited | Wholesale & retail | 1999 |
| Specialist Works Building Maintenance Limited | Real estate | 2009 |
| Specialpreneurs Limited | Administrative & support | 2017 |
| Speedfar Ltd | Transport & logistics | 2018 |
| Speedy Property Lets Limited | Households | 2015 |
| Spektra Events Group Limited | Other services | 2022 |
| Spektra Merchandise Limited | Wholesale & retail | 2026 |
| SPI Design and Construction Limited | Construction | 2019 |
| Spice Buzz Ltd | Hospitality | 2026 |
| Spice Kent Ltd | Hospitality | 2018 |
| Spice Merchant Mutley Ltd | Hospitality | 2019 |
| Spice Merchant MUTLEY1 Limited | Hospitality | 2023 |
| Spicemix Ltd | Hospitality | 2022 |
| Spicer Enterprises Ltd | Financial services | 2023 |
| Spicy Spoon Ltd | Hospitality | 2025 |
| Spike at the Art Ltd | Other services | 2009 |
| Spike-Up Barbers Ltd | Other services | 2016 |
| Spinnaker Land (Eggbuckland) Ltd | Real estate | 2021 |
| Spinnaker Land Ltd | Real estate | 2021 |
| Spinney 1966 Limited | Extraterritorial | 2015 |
| Spirit 13 Music Limited | Information & communication | 2014 |
| Spirit of Plymouth (Radio) Limited | Information & communication | 2006 |
| SPK Construction and Groundworks Limited | Construction | 2022 |
| SPM Property Limited | Construction | 2025 |
| Spoilt Hair Boutique Ltd | Other services | 2022 |
| Spoken Injustice C.I.C. | Other services | 2023 |
| Sport AV Global Limited | Information & communication | 2015 |
| Sport Environment Limited | Arts & recreation | 2001 |
| Sports Cards Direct Ltd | Wholesale & retail | 2018 |
| Sports Cards World Wide Limited | Wholesale & retail | 2024 |
| Sports Coaches South West Limited | Education | 2013 |
| Sports Supplements Plymouth Ltd | Wholesale & retail | 2024 |
| Spot on Climbing Ltd | Arts & recreation | 2024 |
| Spotless Cleaning Plymouth Ltd | Administrative & support | 2026 |
| Spotless Cleaning Services DN Ltd | Administrative & support | 2022 |
| Spp-Uk Limited | Administrative & support | 2006 |
| Spray Away (Plymouth) Limited | Wholesale & retail | 2017 |
| Spray Vision Ltd | Construction | 2022 |
| Spring Moon Limited | Administrative & support | 2005 |
| Springfield Building & Maintenance Ltd | Real estate | 2020 |
| Springfield Catering Ltd | Hospitality | 2018 |
| Springfield Energy Saving Installations Ltd | Construction | 2020 |
| Springfield Mews (Brighton) Management Company Limited | Households | 2019 |
| Springfield Road Golden Ltd | Hospitality | 2026 |
| Springfield Villas Management Co. Limited | Households | 2003 |
| Spry Fabrication Ltd | Administrative & support | 2023 |
| SPS Developments (SW) Ltd | Real estate | 2019 |
| Spud Catering Ltd | Hospitality | 2019 |
| Spurrier Financial Solutions Limited | Financial services | 2016 |
| Squadra Consulting Limited | Information & communication | 2016 |
| Squire Group Limited | Financial services | 2019 |
| Squire Holdings 617 Ltd | Financial services | 2021 |
| Squire Trading Limited | Financial services | 2019 |
| Squires & Gill Ltd | Administrative & support | 2023 |
| SR Care and Support Training Limited | Health & social care | 2016 |
| SR Procurement Training Limited | Administrative & support | 2009 |
| SR Workshop Ltd | Wholesale & retail | 2026 |
| SRD Bricklaying Ltd | Construction | 2024 |
| SRD Ecom Limited | Wholesale & retail | 2026 |
| Srjd Enterprises Limited | Professional & scientific | 2012 |
| Srs.Sarvaiya Ltd | Administrative & support | 2019 |
| SRT (ST Austell) Limited | Education | 2017 |
| SRT KM Management Limited | Administrative & support | 2017 |
| SS & SS Services Ltd | Health & social care | 2019 |
| SS Home Investors Ltd | Real estate | 2026 |
| Ss&Rm Limited | Health & social care | 2020 |
| SSA Bakes Limited | Wholesale & retail | 2025 |
| SSB Plymouth Ltd | Hospitality | 2019 |
| SSD Building Services Limited | Construction | 2015 |
| SSD Group Limited | Manufacturing | 2017 |
| SSG Logistics Ltd | Transport & logistics | 2021 |
| SSG Property Maintenance SW Limited | Construction | 2025 |
| SSH Pantling Limited | Financial services | 2020 |
| Ssky Holdings Ltd | Financial services | 2025 |
| SSR Properties and Holdings Ltd | Real estate | 2025 |
| SSR Waste Ltd | Water & waste | 2017 |
| Ssrm Consulting Ltd | Information & communication | 2013 |
| SSW Engineering Ltd | Professional & scientific | 2019 |
| ST Anne’S House Plymouth Limited | Real estate | 2021 |
| ST Aubyn Terrace Residents Management Company Limited | Households | 2022 |
| ST Bees Property Limited | Real estate | 2020 |
| ST Budeaux Chippy Ltd | Hospitality | 2019 |
| ST Budeaux Community Bar CIC | Hospitality | 2021 |
| ST Budeaux News Ltd | Wholesale & retail | 2023 |
| ST Business Limited | Wholesale & retail | 2023 |
| ST by Name Limited | Administrative & support | 2014 |
| ST David's APL Limited | Health & social care | 2010 |
| ST James Mews (Plymouth) Management Company Limited | Households | 2004 |
| ST Judes Management Company Limited | Households | 1996 |
| ST Lawrence Mews Management Company Limited | Households | 1996 |
| ST Matthew's Church (Elburton) Trust | Extraterritorial | 2009 |
| ST Maurice Bakery Ltd | Wholesale & retail | 2017 |