| South West EAR Clinic Ltd | Health & social care | 2021 |
| South West Eco Energy Ltd | Construction | 2025 |
| South West Engineering Solutions Ltd | Professional & scientific | 2024 |
| South West Fintech Limited | Information & communication | 2024 |
| South West Fire Alarms Limited | Construction | 2009 |
| South West Fire Door Specialists Ltd | Construction | 2025 |
| South West Grappling Limited | Arts & recreation | 2024 |
| South West Heart Rhythm Care Limited | Professional & scientific | 2024 |
| South West Hire and Sales Limited | Administrative & support | 2007 |
| South West Huddle Ltd | Professional & scientific | 2023 |
| South West Laminating Ltd | Manufacturing | 2020 |
| South West Landlords' Association | Other services | 1998 |
| South West Laser Ltd | Administrative & support | 2026 |
| South West Lifting Services Limited | Administrative & support | 2019 |
| South West Medicolegal Ltd | Health & social care | 2025 |
| South West Mini Paver Hire Ltd | Construction | 2016 |
| South West Observatory Ltd | Information & communication | 2025 |
| South West Property and Lettings Ltd | Real estate | 2025 |
| South West Property Hub Ltd | Real estate | 2021 |
| South West Property Services and Maintenance Ltd | Other services | 2018 |
| South West Removals & Storage Ltd | Transport & logistics | 2014 |
| South West Residential Homes Limited | Health & social care | 2006 |
| South West Sparks Limited | Construction | 2021 |
| South West Structures Limited | Professional & scientific | 2019 |
| South West SUP Limited | Education | 2017 |
| South West Supply Co Ltd | Wholesale & retail | 2025 |
| South West Survival Ltd | Education | 2019 |
| South West Suspension Ltd | Other services | 2026 |
| South West Tax Limited | Professional & scientific | 2012 |
| South West Tiling Limited | Construction | 2013 |
| South West Trade Sales Ltd | Wholesale & retail | 2024 |
| South West Traders Limited | Wholesale & retail | 1997 |
| South West Training Solutions Limited | Education | 2006 |
| South West Uniforms Limited | Wholesale & retail | 2012 |
| South West Watch Company Ltd | Wholesale & retail | 2024 |
| South West Welding Supplies Ltd | Manufacturing | 2005 |
| Southcokitchensandcarpentry Ltd | Construction | 2025 |
| Southcott Specialist Cars Ltd | Wholesale & retail | 2012 |
| Southdown Marina Limited | Administrative & support | 2015 |
| Southern Bricklaying Services Ltd | Construction | 2021 |
| Southern Building & Maintenance Ltd | Construction | 2026 |
| Southern Construction & Extensions Ltd | Construction | 2023 |
| Southern Decon Ltd | Health & social care | 2018 |
| Southern Electrical (South West) Limited | Energy | 2003 |
| Southern GAS Plumbing Solutions Limited | Construction | 2022 |
| Southern Leisure Ltd | Real estate | 2021 |
| Southkey Properties Limited | Real estate | 2021 |
| Southmore Ltd | Construction | 2016 |
| Southside Better Roofs Ltd | Energy | 2026 |
| Southside Sales Ltd | Energy | 2018 |
| Southside Street Limited | Real estate | 2014 |
| Southway UK Pizza Ltd | Hospitality | 2025 |
| Southway Barber Shop Ltd | Other services | 2019 |
| Southway Community Group Community Interest Company | Hospitality | 2014 |
| Southway Foodie Limited | Hospitality | 2024 |
| Southway Pizza Ltd | Hospitality | 2019 |
| Southway Service Station Limited | Wholesale & retail | 2004 |
| Southway Tandoori Ltd | Hospitality | 2024 |
| Southwest Firedoor Solutions Ltd | Manufacturing | 2023 |
| Southwest Funeral Care Limited | Other services | 2020 |
| Southwest Gaming Ltd | Arts & recreation | 2023 |
| Southwest Garden Services Ltd | Construction | 2024 |
| Southwest Inclusive CIC | Education | 2024 |
| Southwest Mastic Asphalte Co. Limited | Construction | 1971 |
| Southwest Metals Ltd | Water & waste | 2012 |
| Southwest Neuro Ltd | Education | 2020 |
| Southwest Renewables Ltd | Construction | 2011 |
| Southwest Rentals & Maintenance Ltd | Construction | 2026 |
| Southwest Roofing and Construction Ltd | Construction | 2026 |
| Southwest Screed Specialist Limited | Construction | 2015 |
| Southwest Screeding Solutions Ltd | Construction | 2018 |
| Southwest Security Limited | Financial services | 2018 |
| Southwest Shrinkwrap Limited | Construction | 2020 |
| Southwest Sprayers Ltd | Construction | 2009 |
| Southwest Veins Limited | Health & social care | 2017 |
| Southwest Wind Services Ltd | Manufacturing | 2025 |
| Southwesterly Marine Ltd | Arts & recreation | 2021 |
| Soutway Pizza and Chicken House Limited | Hospitality | 2021 |
| Sovereign Preservation Devon and Cornwall Ltd | Construction | 2023 |
| Sovereign Scaffolding (South West) Limited | Construction | 2007 |
| Sovereign Scaffolding Holdings Limited | Financial services | 2025 |
| Sovereign Wines Ltd | Wholesale & retail | 2003 |
| Sozo Tattoo Studio Limited | Other services | 2025 |
| SP Build & Design Ltd | Construction | 2025 |
| SP Storage and Distribution Limited | Transport & logistics | 2019 |
| Space Adapt Learn Grow Limited | Public administration | 2025 |
| Space Control Southwest Limited | Construction | 2021 |
| Space LA Ltd | Professional & scientific | 2025 |
| Space Landscape Architects Ltd | Administrative & support | 2020 |
| Space Storage Ltd | Administrative & support | 2006 |
| Space to Move Ltd | Arts & recreation | 2018 |
| Space Tonic Architects Ltd | Professional & scientific | 2025 |
| Space Unicorns Ltd | Information & communication | 2014 |
| Spackman Associates Limited | Professional & scientific | 2006 |
| Spar Colebrook Ltd | Wholesale & retail | 2007 |
| Spare Storage Ltd | Transport & logistics | 2026 |
| Spark and Mend Ltd | Administrative & support | 2025 |
| Spark Commercial UK Ltd | Construction | 2023 |
| Sparkling White Carpet Cleaning Ltd | Administrative & support | 2021 |
| Sparkling White Cleaning Services Ltd | Administrative & support | 2021 |