| Smartway Building Services Ltd | Construction | 2021 |
| Smartworks Engineering Limited | Construction | 2025 |
| Smash Haus Golf Limited | Arts & recreation | 2026 |
| Smash N Bake Limited | Hospitality | 2025 |
| Smashed & Loaded (Deeping) Ltd | Hospitality | 2025 |
| Smashed UP Foods Limited | Hospitality | 2023 |
| SMB Inventories Ltd | Administrative & support | 2024 |
| SMH Executive Ltd | Wholesale & retail | 2024 |
| Smile and Snacks Ltd | Wholesale & retail | 2026 |
| Smile Perfection 7 Limited | Health & social care | 2024 |
| Smile Symbol Ltd | Health & social care | 2015 |
| Smiley Donkey Ltd | Professional & scientific | 2023 |
| Smiley Faces Day Nursery (Thorney) Limited | Education | 2006 |
| Smilte Services Ltd | Transport & logistics | 2024 |
| Smir Medical Limited | Health & social care | 2024 |
| Smith & Richards Ltd | Professional & scientific | 2012 |
| Smith Construction (Holdings) Limited | Financial services | 2018 |
| Smith Lacey Limited | Wholesale & retail | 2010 |
| Smith Planning & Building Ltd | Construction | 2009 |
| Smith-Vaughan Limited | Information & communication | 2020 |
| Smiths Funeral Directors Ltd | Other services | 2011 |
| Smiths Leisure Homes Limited | Hospitality | 2014 |
| SMM PB Ltd | Wholesale & retail | 2018 |
| SMN Motors Ltd | Wholesale & retail | 2025 |
| Smok'D OUT Ltd | Hospitality | 2024 |
| Smoked OUT Limited | Hospitality | 2025 |
| Smoking Dough Limited | Hospitality | 2023 |
| Smooth Brickwork Ltd | Construction | 2025 |
| Smooth Move Service UK Ltd | Transport & logistics | 2026 |
| Smooth Results Carpentry Ltd | Manufacturing | 2023 |
| Smre-Uk Ltd | Professional & scientific | 2021 |
| Smrt Group Ltd | Professional & scientific | 2024 |
| Smuv Digital Solutions Limited | Information & communication | 2021 |
| SMV Trans Courier Ltd | Transport & logistics | 2020 |
| SMW Surfacing Limited | Construction | 2024 |
| Smykk Trans Ltd | Transport & logistics | 2023 |
| Smythington Royce Inc Limited | Professional & scientific | 2014 |
| Smythsonian Limited | Information & communication | 2017 |
| SN Brix&Build Limited | Construction | 2020 |
| Snap U Ltd | Professional & scientific | 2025 |
| Snape Transport Limited | Transport & logistics | 2010 |
| Snapplent Limited | Wholesale & retail | 2023 |
| Snappy Food Ltd | Hospitality | 2025 |
| Snappy Grill Food Ltd | Hospitality | 2026 |
| Snaps Investments Limited | Real estate | 2024 |
| Snapstaff Ltd | Administrative & support | 2026 |
| Snart Solutions Limited | Manufacturing | 2017 |
| Snasib Consultancy Ltd | Construction | 2019 |
| Snax Group Limited | Wholesale & retail | 2022 |
| SND Investments Limited | Wholesale & retail | 2026 |
| Snel Ltd | Extraterritorial | 2020 |
| Snip&Style Limited | Other services | 2025 |
| Snipr Biome UK Limited | Professional & scientific | 2021 |
| Snipr Technologies Limited | Professional & scientific | 2015 |
| SNJ Partnership Ltd | Wholesale & retail | 2021 |
| Snmunro Houses Ltd | Real estate | 2025 |
| Snow FOX Studio Ltd | Information & communication | 2026 |
| Snowy's Properties Ltd | Real estate | 2025 |
| Snuggle Limited | Wholesale & retail | 2011 |
| SO Brand Creative Limited | Professional & scientific | 2016 |
| Soar Building Solutions Ltd | Construction | 2021 |
| Soccer Stars Manchester North West Ltd | Arts & recreation | 2021 |
| Social Enterprises Plus Ltd | Professional & scientific | 2013 |
| Social Media Time Limited | Professional & scientific | 2021 |
| Social Work Health and Training Solutions Limited | Other services | 2014 |
| Socialpoints Technology Ltd | Information & communication | 2026 |
| Socommunity Ltd | Professional & scientific | 2013 |
| Sodaflo Limited | Manufacturing | 2018 |
| Sofaplus Ltd | Wholesale & retail | 2013 |
| Sofia Education Limited | Professional & scientific | 2012 |
| Sofiacojo Ltd | Administrative & support | 2026 |
| Sofiaelenadobre Ltd | Transport & logistics | 2022 |
| Sofka Limited | Transport & logistics | 2022 |
| Softbeck Limited | Wholesale & retail | 2024 |
| Softhomes Limited | Real estate | 2025 |
| Softio Ltd | Information & communication | 2019 |
| Softlanding Designs Limited | Construction | 2025 |
| Softmed Limited | Real estate | 2022 |
| Sognare 777 Ltd | Transport & logistics | 2025 |
| Sohail Pharm Ltd | Health & social care | 2022 |
| Soho Manor Property Limited | Real estate | 2024 |
| Soiié Ltd | Other services | 2025 |
| Soil Power Energy Limited | Water & waste | 2024 |
| Sojok Ltd | Wholesale & retail | 2023 |
| Sojos Enterprise GB Ltd | Wholesale & retail | 2021 |
| Soke 2000 Limited | Extraterritorial | 2009 |
| Soke Consulting Limited | Professional & scientific | 2015 |
| Soke Education Trust | Education | 2017 |
| Soke Engineering Limited | Professional & scientific | 2025 |
| Soke Leisure Limited | Hospitality | 1995 |
| SOL E MAR Van Co Limited | Wholesale & retail | 2026 |
| Solar Polar Limited | Professional & scientific | 2007 |
| Solaris Tanning Studio (Peterborough) Ltd | Other services | 2019 |
| Solav UK Supermarket Ltd | Wholesale & retail | 2024 |
| Soleite Limited | Financial services | 2024 |
| Solidus Construction Services Ltd | Construction | 2014 |
| Solidus Logistics Ltd | Transport & logistics | 2023 |
| Solodko Ltd | Hospitality | 2026 |
| Solomon Ian-Sangala Ltd | Other services | 2021 |
| Solomon Serviced Accommodation Ltd | Real estate | 2022 |