| Ryan & Kave Ltd | Administrative & support | 2017 |
| S & J Enterprises (SW) Limited | Real estate | 2023 |
| S & J Property (SW) Ltd | Real estate | 2024 |
| S & J Trawlers Limited | Agriculture & fishing | 2020 |
| S & L Construction (Torbay) Ltd | Construction | 2019 |
| S & L Rosser Limited | Real estate | 2003 |
| S Allen Property Solutions Limited | Construction | 2021 |
| S C Computing & Networking Ltd | Manufacturing | 2022 |
| S Davis Ltd | Other services | 2024 |
| S I Design & Construction Limited | Construction | 2012 |
| S J Mechanical Services Ltd | Administrative & support | 2017 |
| S.B Stove Innovations Ltd | Construction | 2025 |
| Saber Combat Academy Ltd. | Arts & recreation | 2016 |
| Sadie Morgan Aesthetics Limited | Health & social care | 2024 |
| Safespan Scaffolding Ltd | Construction | 2025 |
| Sagetech Medical Equipment Limited | Manufacturing | 2015 |
| Saimar Ventures Ltd | Mining & quarrying | 2020 |
| Saju & Ligi's Ltd | Health & social care | 2015 |
| Samis Group Ltd | Real estate | 2023 |
| Sanabel Court Residents Association Limited | Real estate | 1979 |
| Sandilands Investments South West Ltd | Real estate | 2026 |
| Sandstone Court Management Company Limited | Households | 2025 |
| Sandway Estate Holdings Limited | Hospitality | 2020 |
| Sandy Point Developments Limited | Construction | 2026 |
| Santos&Martins Ltd | Hospitality | 2019 |
| Sark Solutions Limited | Professional & scientific | 2019 |
| Saving Energy Group Limited | Construction | 2011 |
| SC Glass and Glazing Ltd | Construction | 2018 |
| Scale Products Ltd | Manufacturing | 2023 |
| Scientific Innovations Ltd | Manufacturing | 2024 |
| Scoopz Dessert Parlour Ltd | Hospitality | 2020 |
| Scootsport CIC | Professional & scientific | 2013 |
| Scott Flanders Limited | Administrative & support | 1995 |
| Scowt Ltd | Professional & scientific | 2025 |
| Scrivania Ltd | Professional & scientific | 2017 |
| Scylla Engineering Limited | Professional & scientific | 2024 |
| Sea & Sea Limited | Wholesale & retail | 1979 |
| Sea and Sea (Holdings) Limited | Wholesale & retail | 2003 |
| Sea Point Paignton Ltd | Households | 2012 |
| Seacroft Court Management (Paignton) Limited | Households | 1991 |
| Seahorses Swim School Ltd | Education | 2018 |
| Seamus O'Donnells (Torquay) Ltd | Hospitality | 2022 |
| Seapoint (Cliff Road) Management Limited | Households | 2006 |
| Seareach Apartments Ltd | Professional & scientific | 2004 |
| Seaside Catering Co Limited | Hospitality | 2017 |
| Seaside Havens Ltd | Real estate | 2021 |
| Seasons Psychology Limited | Health & social care | 2023 |
| Seaway Construction Ltd | Construction | 2021 |
| SEG Construction Ltd | Construction | 2017 |
| Select Trade Brands Ltd | Wholesale & retail | 2003 |
| Sequeens Ltd | Wholesale & retail | 2016 |
| Seren Media Limited | Information & communication | 2025 |
| Serious About Events Limited | Arts & recreation | 2015 |
| Setting OUT Limited | Information & communication | 2009 |
| Seven Hills ABC CIC | Arts & recreation | 2024 |
| Severn View Property Limited | Real estate | 2024 |
| Sgpl Limited | Health & social care | 2023 |
| Sharp Design and Build Limited | Construction | 2023 |
| Shears Fishing Ltd | Agriculture & fishing | 2014 |
| Sheilamarcella Limited | Hospitality | 2019 |
| Sherwell Valley Garage Limited | Wholesale & retail | 2025 |
| Shoot OUT Club Ltd | Arts & recreation | 2002 |
| Shoot OUT Club Transport Limited | Transport & logistics | 2010 |
| Shore Engineering Services Ltd | Professional & scientific | 2020 |
| Shutters and Blinds South West Limited | Wholesale & retail | 2025 |
| Shuò Chén Consulting UK Ltd | Professional & scientific | 2025 |
| Sian Aesthetics Ltd | Health & social care | 2019 |
| Siddall Rental Properties Ltd | Real estate | 2026 |
| Sidmount Sidmouth Management Limited | Households | 2004 |
| Signal Financial Services Limited | Financial services | 2006 |
| Silent Revolution Ltd | Wholesale & retail | 2021 |
| Silver Service Ltd | Other services | 2013 |
| Simon Pedrick Limited | Manufacturing | 1999 |
| Simple Car & Van Hire Ltd | Administrative & support | 2016 |
| Simply Joy Care Services Ltd | Health & social care | 2021 |
| Sixty Four Construction Ltd | Construction | 2025 |
| Sixty Four Consultancy Ltd | Professional & scientific | 2023 |
| Sixty Four Holdings Ltd | Financial services | 2025 |
| Sizzling Grill (SW) Ltd | Hospitality | 2024 |
| SJ & D Trawlers Ltd | Agriculture & fishing | 2020 |
| Skin Wellness Ltd | Wholesale & retail | 2024 |
| Skippy Construction Limited | Construction | 2007 |
| Skippy Lettings Limited | Real estate | 2019 |
| Skytech Surveys Ltd | Information & communication | 2023 |
| Skyway MAN Ltd | Wholesale & retail | 2020 |
| Slackproductions Ltd | Arts & recreation | 2011 |
| Sludge Slayers Ltd | Water & waste | 2025 |
| Slug and Snail Fencing Limited | Extraterritorial | 2011 |
| SLV Estates Ltd | Households | 2014 |
| SLV Lodges Ltd | Other services | 2016 |
| Smart Business Corp Ltd | Construction | 2015 |
| Smart Tech Renewable Energies Limited | Professional & scientific | 2014 |
| SMD Holdings SW Limited | Financial services | 2023 |
| Smith Marine SW Limited | Manufacturing | 2019 |
| Smoke & Vape 4 U Limited | Wholesale & retail | 2025 |
| Smoked Southwest Limited | Construction | 2025 |
| Smokey Joes SW Ltd | Hospitality | 2017 |
| SO Paignton (Seamus O'Donnells) Ltd | Hospitality | 2017 |
| Social Catapult Ltd | Professional & scientific | 2022 |
| Soil Solutions SW Ltd | Water & waste | 2024 |