| Document Flow Ltd. | Information & communication | 1997 |
| DOD Media Limited | Administrative & support | 2016 |
| Dodds Consulting Limited | Health & social care | 2017 |
| Dodge Solar Ltd | Construction | 2026 |
| Dodrotu Limited | Manufacturing | 2020 |
| Dogpie Ltd | Financial services | 2020 |
| Dolly's Investments Limited | Real estate | 2022 |
| Domains.Coop Limited | Information & communication | 2012 |
| Dominican Council(The) | Extraterritorial | 1944 |
| Domino Carpentry Ltd | Manufacturing | 2024 |
| Dominus Holdings Ltd | Real estate | 2021 |
| Domus Monsai Limited | Real estate | 2008 |
| Don'T Walk Ltd | Professional & scientific | 2023 |
| Dongnai Group Ltd | Hospitality | 2025 |
| Donnington Doorstep | Health & social care | 2011 |
| Donnington Social Club CIC | Hospitality | 2025 |
| Doodilydoo Limited | Education | 2021 |
| Doodool Talaa Limited | Administrative & support | 2018 |
| Dooneen Properties Limited | Real estate | 2016 |
| Door 78 Ltd | Wholesale & retail | 2024 |
| Dorchester Fireplaces Ltd | Administrative & support | 2023 |
| Dorman Traffic Products Limited | Extraterritorial | 1920 |
| Dorman Traffic Products Pension Trustees Limited | Extraterritorial | 1991 |
| Doruk and Partners Ltd | Information & communication | 2026 |
| Doski News Ltd | Wholesale & retail | 2023 |
| Dosti Construction Ltd | Construction | 2023 |
| Dough Magic UK Ltd | Wholesale & retail | 2025 |
| Dousa Limited | Real estate | 2020 |
| Dove House Park Management Company Ltd | Households | 2021 |
| Down the Stretch Productions Ltd | Information & communication | 2022 |
| Downland Capital Limited | Professional & scientific | 2023 |
| Downland Estate Limited | Financial services | 2023 |
| Downland Office Limited | Administrative & support | 2023 |
| DP Cleaning Services Ltd | Administrative & support | 2019 |
| DPC Carpentry Ltd | Construction | 2026 |
| DPD Student Accommodation Ltd | Construction | 2016 |
| DPQ Trading Limited | Real estate | 2000 |
| DQ Property Limited | Real estate | 2020 |
| DR Chantler Limited | Health & social care | 2011 |
| DR Dorcus Muchiri. Ltd | Professional & scientific | 2025 |
| DR Gael M Maclean Ltd | Health & social care | 2021 |
| DR J Mason Limited | Health & social care | 2015 |
| DR Joyce Limited | Health & social care | 2015 |
| DR Melissa Fitzgerald Ltd | Health & social care | 2021 |
| DR Nick Hayward Ltd | Professional & scientific | 2025 |
| DR Pratsou Dermatology Limited | Health & social care | 2015 |
| DR Punwani Limited | Health & social care | 2014 |
| DR R J Sawyer Ltd | Health & social care | 2019 |
| DR R J Turner Holdings Limited | Financial services | 2022 |
| DR R J Turner Ltd | Health & social care | 2014 |
| DR RK Hoyles Limited | Health & social care | 2016 |
| DR S J Wilson Anaesthetic Services Limited | Health & social care | 2021 |
| DR S M Downes Limited | Health & social care | 2013 |
| DR Susan Cooper (Oxford) Limited | Health & social care | 2012 |
| DR V Oral Care Ltd | Health & social care | 2023 |
| DR. Prad Anand, Oral and Maxillofacial Services Limited | Health & social care | 2016 |
| Dragon Bowl Ltd | Hospitality | 2017 |
| Dragon School Hatchlings Ltd | Education | 2026 |
| Dragon School International Ltd | Administrative & support | 2024 |
| Dragon School Trading Limited | Wholesale & retail | 1978 |
| Dragonfly Transforms Ltd | Professional & scientific | 2020 |
| Dragutrans Ltd | Transport & logistics | 2015 |
| Drain Investigation Handlers Ltd | Water & waste | 2019 |
| Dranom Management Limited | Extraterritorial | 2017 |
| Drayton Park Golf Course (Abingdon) Limited | Arts & recreation | 1997 |
| DRB Digital Limited | Information & communication | 2016 |
| DRE Partners Ltd | Professional & scientific | 2017 |
| Dread Star Ltd | Hospitality | 2022 |
| Dream a Dream UK | Health & social care | 2012 |
| Dream Lifestyle Profits Ltd | Other services | 2024 |
| Dream Moments Ltd | Wholesale & retail | 2026 |
| Dream Weaver Entertainment Group Ltd | Information & communication | 2024 |
| Dreamcove Ltd | Wholesale & retail | 2024 |
| Dreamdwell Ventures Limited | Real estate | 2024 |
| Dreamheavy Films Ltd | Information & communication | 2023 |
| Dreaming Spires Consultants Ltd | Professional & scientific | 2015 |
| Dreamline Oxford Ltd | Transport & logistics | 2026 |
| Dreamy Spires Ltd | Wholesale & retail | 2023 |
| Drenchwear Limited | Professional & scientific | 1994 |
| Drewett & Hunt Construction Limited | Construction | 2003 |
| Drinks CC Limited | Other services | 2011 |
| Driveline Automotive Ltd | Wholesale & retail | 2026 |
| Driving Technical Training Limited | Extraterritorial | 2023 |
| DRL Associates Limited | Information & communication | 2003 |
| Drmatthewjervis Limited | Health & social care | 2022 |
| Droidhub Ltd | Information & communication | 2025 |
| Droitwich Sushi Ltd | Wholesale & retail | 2024 |
| Dromologue Ltd | Information & communication | 2023 |
| DRS Remodelling Ltd | Construction | 2025 |
| Drug Discovery Limited | Professional & scientific | 2014 |
| Drummond Scott Limited | Professional & scientific | 2009 |
| DS Roofing South Ltd | Construction | 2024 |
| DSA Private Ltd | Wholesale & retail | 2022 |
| DSH Car Sales Ltd | Wholesale & retail | 2024 |
| DSV Advisory Ltd | Transport & logistics | 2014 |
| Dthaps Services Limited | Professional & scientific | 2018 |
| Dual Marketing and Recruitment Consulting Limited | Professional & scientific | 2014 |
| Duaox Limited | Hospitality | 2025 |
| Dubber Ltd | Information & communication | 2016 |
| Dubber UK Holdings Limited | Information & communication | 2020 |