| Scott Lucas Ltd | Wholesale & retail | 2018 |
| Scott Monahan Carpentry Ltd | Construction | 2022 |
| Scottie Limited | Transport & logistics | 2016 |
| Screen Masters International Ltd | Arts & recreation | 2020 |
| Scudamore & Co. Interiors Limited | Construction | 2026 |
| Sculpted Cosmetics Ltd | Wholesale & retail | 2024 |
| SD Fibre Optic Ltd | Information & communication | 2023 |
| Sdkn Properties Limited | Real estate | 2024 |
| Sdlt Stamp Check UK Limited | Information & communication | 2024 |
| Sdsys Limited | Information & communication | 2005 |
| SE Marketing Limited | Information & communication | 2021 |
| Seacross Limited | Transport & logistics | 2014 |
| Seafood Base Ltd | Wholesale & retail | 2026 |
| SEB IP Holdings Ltd | Administrative & support | 2012 |
| Seco Construction Services Ltd | Professional & scientific | 2015 |
| Secretroom Experience Ltd | Other services | 2023 |
| Secure Solutions London Ltd | Administrative & support | 2025 |
| Secureformal Property Management Limited | Households | 1996 |
| Security AGE Ltd | Information & communication | 2021 |
| SED Consult Ltd | Construction | 2009 |
| SED Properties Ltd | Real estate | 2026 |
| Seeded Assets Limited | Real estate | 2018 |
| Seekers Collective Ltd | Information & communication | 2019 |
| Seerbit Limited | Financial services | 2023 |
| Segeogis Ltd | Professional & scientific | 2021 |
| Segma Telecoms Ltd | Information & communication | 2010 |
| Seka Properties Ltd | Real estate | 2021 |
| Selkent Fastenings Ltd | Wholesale & retail | 2013 |
| Selkent Investments Ltd | Administrative & support | 2019 |
| Selva & Sons Ltd | Wholesale & retail | 2015 |
| Semosh Ltd | Hospitality | 2019 |
| Senara Investments Limited | Financial services | 2025 |
| Sentient Therapy Limited | Other services | 2022 |
| Sentient Wealth Management Limited | Financial services | 2017 |
| Sequoia Brickwork Ltd | Construction | 2015 |
| Sequoia Property Lettings Ltd | Real estate | 2025 |
| Serenity INK Ltd | Wholesale & retail | 2018 |
| Serketin Consulting Services Limited | Information & communication | 2023 |
| Served Holding Ltd | Information & communication | 2025 |
| SET & Co Holdings Limited | Financial services | 2024 |
| Setforlife Limited | Information & communication | 2017 |
| Sets and Scenery (London) Ltd | Construction | 2019 |
| Seven Angels London Ltd | Wholesale & retail | 2025 |
| Seven Estates Property Ltd | Real estate | 2016 |
| Seven Farnley Road Freehold Limited | Real estate | 2014 |
| Seventhills Ltd | Construction | 2024 |
| Seymour Projects Construction Limited | Construction | 2018 |
| Sfvr Property Limited | Real estate | 2021 |
| SG Brothers International Ltd | Real estate | 2022 |
| SG London & Kent Ltd | Professional & scientific | 2024 |
| SGK Consultants Limited | Information & communication | 2014 |
| SGL Refurbishment Specialists Ltd | Construction | 2023 |
| Sgobhairigh Ltd | Professional & scientific | 2020 |
| SH Suppliers Ltd | Extraterritorial | 2023 |
| Shaan Engineering Ltd | Construction | 2023 |
| Shacklands Investments Limited | Financial services | 2023 |
| Shadow Property 2 Ltd | Real estate | 2020 |
| Shadow Security Global Ltd | Other services | 2010 |
| Shafia Holdings Ltd | Real estate | 2021 |
| Shakti Enterprise Limited | Real estate | 2023 |
| Shalom Community Services Limited | Extraterritorial | 2020 |
| Shane Consultancy Limited | Professional & scientific | 2018 |
| Shanelle Enterprises Ltd | Administrative & support | 2017 |
| Shannon and Leach Surveying Limited | Professional & scientific | 1989 |
| Shape Sculpt Body Ltd | Other services | 2026 |
| Shapeshift Therapy Ltd | Other services | 2025 |
| Shard International Ltd | Professional & scientific | 2015 |
| Sharma Consulting Services Limited | Professional & scientific | 2007 |
| Shazam Services Ltd | Administrative & support | 2022 |
| SHE WHO Dares Productions Limited | Information & communication | 2020 |
| Shedams Ltd | Information & communication | 2026 |
| Shelbrook Limited | Construction | 2016 |
| Shelita Limited | Hospitality | 2024 |
| Shelleys Hair Studio Limited | Wholesale & retail | 2009 |
| Shemil Properties Ltd | Real estate | 2024 |
| Shepherd Electrical Limited | Construction | 2007 |
| Sheppard Homes Limited | Construction | 2013 |
| Sheppex Finance Limited | Extraterritorial | 2017 |
| Sheppex Investments Limited | Extraterritorial | 2017 |
| Sheppex Limited | Financial services | 2017 |
| Sheridan Place (Bromley) Freehold Management Company Limited | Households | 2006 |
| Sheridan Place (Bromley) Leasehold Management Company Limited | Households | 2006 |
| SHG Digital Limited | Information & communication | 2022 |
| Shibuya Ltd | Information & communication | 2016 |
| Shield Pest Control (UK) Limited | Administrative & support | 1993 |
| Shield Pest Control Limited | Administrative & support | 2009 |
| Shields Restoration Limited | Professional & scientific | 2016 |
| Shields Stonework & Restoration Limited | Construction | 2009 |
| Shilpabhi Investments Ltd | Real estate | 2023 |
| Shimmering Stars Limited | Education | 2018 |
| Shinecart Ltd | Wholesale & retail | 2025 |
| Shiras DEN Limited | Wholesale & retail | 2020 |
| Shirley's Ice Cream Ltd | Hospitality | 2022 |
| Shiv P Limited | Health & social care | 2015 |
| Shivani Shah Limited | Education | 2026 |
| Shonorities Ltd | Arts & recreation | 2015 |
| Shopfront Services (Southern) Limited | Construction | 2007 |
| Shorter & Co (London) Limited | Other services | 2015 |
| Shree SAI Solutions PVT Ltd | Information & communication | 2015 |
| Shreeji Furniture Ltd | Wholesale & retail | 2024 |