| Safesquare Residents Management Limited | Households | 1987 |
| Saffron Investments Limited | Real estate | 2003 |
| Saffron Property Management Ltd | Construction | 2011 |
| Safraan LLP | | 2023 |
| Safzak Estates Ltd | Real estate | 2019 |
| Safzak Medical Limited | Financial services | 2015 |
| SAG Support Services Limited | Construction | 2018 |
| Sageeth Ltd | Real estate | 2024 |
| Sagent Solutions Ltd | Real estate | 2016 |
| Saglio Boiler Services Limited | Other services | 2002 |
| SAI Virar Limited | Health & social care | 2015 |
| Saigon Bar and Grill Ltd | Hospitality | 2020 |
| Saima Aslam Ltd | Wholesale & retail | 2021 |
| Saima Consultancy Ltd | Information & communication | 2017 |
| Saima Estates Limited | Real estate | 2020 |
| Saini Developments Limited | Construction | 2003 |
| Saint Justins Home Ltd | Real estate | 2022 |
| SAJ Selva Media Ltd | Professional & scientific | 2019 |
| Sakala Ltd | Information & communication | 2015 |
| Sakkthi Distribution Ltd | Wholesale & retail | 2026 |
| Sakthi Property Ltd | Real estate | 2023 |
| Sakthis Care Ltd | Administrative & support | 2023 |
| Sakura Property Services Limited | Professional & scientific | 2017 |
| SAL DES Mamans Limited | Health & social care | 2025 |
| Salamat Properties Ltd | Real estate | 2024 |
| Salessign Limited | Information & communication | 2025 |
| Salh Medical Services Ltd | Health & social care | 2026 |
| Salient Studio Limited | Wholesale & retail | 2017 |
| Salle Properties Limited | Real estate | 2023 |
| Salli Corporation Ltd | Wholesale & retail | 2025 |
| Salt and Light Inc Solutions Ltd | Information & communication | 2015 |
| Salt Lake Medical Limited | Health & social care | 2016 |
| Saltgrass Entertainment Limited | Information & communication | 2022 |
| Saltlight Ltd | Information & communication | 2015 |
| Salya & Lavya Ltd | Real estate | 2021 |
| SAM Palladio Limited | Arts & recreation | 2011 |
| SAM Saunders Limited | Construction | 2022 |
| Sama Collective Ltd | Real estate | 2025 |
| Sama Studio Ltd | Administrative & support | 2013 |
| Samac Construction Services Limited | Construction | 1995 |
| Samac Construction Services Trustees Limited | Other services | 2026 |
| Samantha & Charmani Ltd | Health & social care | 2015 |
| Samrette Limited | Financial services | 2014 |
| Samsun Catering Ltd | Hospitality | 2026 |
| SAMSUN55 Limited | Hospitality | 2023 |
| Samtan Limited | Real estate | 2013 |
| Samuel Gordon Insurance Brokers Limited | Financial services | 2011 |
| Sanaa Studio Limited | Professional & scientific | 2004 |
| Sanctorrium Limited | Other services | 2018 |
| Sand Global Sourcing & Consulting Ltd | Wholesale & retail | 2019 |
| Sandford Close Management Co. Limited | Households | 1980 |
| Sandons Business Services UK Limited | Transport & logistics | 2012 |
| Sanisha Services Limited | Health & social care | 2023 |
| Sanka Soft Ltd | Information & communication | 2015 |
| Sanvera Technologies Limited | Information & communication | 2013 |
| Sanzo Properties Ltd | Real estate | 2020 |
| Sapphire Connection Ltd | Information & communication | 2021 |
| Sapt Property Limited | Real estate | 2025 |
| Sapt Technologies Ltd | Information & communication | 2021 |
| Sarah Craighill Accounting Services Ltd | Professional & scientific | 2021 |
| Saras Construction Ltd | Construction | 2019 |
| Sarin Associates Limited | Professional & scientific | 2019 |
| Sarmad Al-Kiar Limited | Health & social care | 2024 |
| Saroj Management Services Ltd | Real estate | 2023 |
| Sarv SK Ltd | Professional & scientific | 2010 |
| Sasha&Team Ltd | Construction | 2021 |
| Saso Homes Ltd | Real estate | 2021 |
| Sasta GAS Limited | Construction | 2024 |
| SAT Soft PVT Ltd | Information & communication | 2010 |
| Satirev Ltd | Administrative & support | 2025 |
| Satori Global Ltd | Professional & scientific | 2023 |
| Satro Ltd | Administrative & support | 2013 |
| Satte Real Estate Ltd | Real estate | 2023 |
| Saul Analytics Ltd | Information & communication | 2024 |
| Savara Tack Ltd | Wholesale & retail | 2019 |
| Savo Property Services Limited | Real estate | 2018 |
| Savo Rose Abbey Wood Limited | Financial services | 2024 |
| Savo Rose Barnehurst Limited | Financial services | 2024 |
| Savo Rose Enterprises Limited | Real estate | 2020 |
| Savoia International Limited | Financial services | 2017 |
| Savoy Solutions Ltd | Construction | 2024 |
| Savur Associates Limited | Professional & scientific | 2018 |
| Sayhoo Media Ltd | Information & communication | 2010 |
| SB Electric Solutions Ltd | Construction | 2012 |
| SB Immigration Ltd | Professional & scientific | 2016 |
| SB Pipe Services Ltd | Construction | 2014 |
| SBI Buchanan Ltd | Construction | 2014 |
| SBI Buchanan Property Ltd | Real estate | 2016 |
| Sbj.Property Services. Ltd. | Construction | 2004 |
| SBM Real Estate Ltd | Real estate | 2025 |
| SBS Recycling Limited | Extraterritorial | 2001 |
| Sc&L Signalling Limited | Construction | 2023 |
| Scan for Life Limited | Health & social care | 2008 |
| Scanlon Restoration Limited | Construction | 2007 |
| SCE Civil Engineering Ltd | Construction | 2023 |
| Scentory London Ltd | Wholesale & retail | 2026 |
| Schab Limited | Education | 2021 |
| Scooter Corner Ltd | Transport & logistics | 2021 |
| Scope Recruitment Ltd | Administrative & support | 2019 |
| Scopethemarket Ltd | Information & communication | 2026 |