| Spectroserv Limited | Professional & scientific | 2003 |
| Spectrum Reliable Care Limited | Health & social care | 2012 |
| Spectrum Social Work Assessments Ltd | Health & social care | 2021 |
| Speed Print Ltd | Manufacturing | 2022 |
| Speed With Wings Ltd | Transport & logistics | 2025 |
| Speedex NW UK Ltd | Administrative & support | 2019 |
| Speedex Solution Ltd | Administrative & support | 2024 |
| Speedo X Logistics Ltd | Transport & logistics | 2023 |
| Speedwell Accountants Ltd | Professional & scientific | 2018 |
| Speedwell Racing Ltd | Wholesale & retail | 2022 |
| Speedwell Services Ltd | Wholesale & retail | 2020 |
| Speedy Cargo Services Manchester Ltd | Water & waste | 2024 |
| Speedy Claims Limited | Professional & scientific | 2018 |
| Speedy Clutch Ltd | Wholesale & retail | 2012 |
| Speedy Fast Courier Limited | Transport & logistics | 2024 |
| Speedy Logistics Services Ltd | Administrative & support | 2026 |
| Speedy Remit Ltd | Professional & scientific | 2024 |
| Speedy Reporting Limited | Administrative & support | 2020 |
| Speedy Tyres & Auto Care Ltd | Wholesale & retail | 2025 |
| Speedymedicals Ltd | Administrative & support | 2017 |
| Spence & Co. Property Agents Ltd | Real estate | 2023 |
| Spence & Warren Electrical Limited | Construction | 2021 |
| Spencer Barclays Limited | Other services | 2010 |
| Spencer Lloyd Global Limited | Administrative & support | 2023 |
| Spencer Reid Limited | Real estate | 2023 |
| Spent Worm Limited | Wholesale & retail | 2013 |
| Spex Properties Management Ltd | Real estate | 2025 |
| Speyside Ltd | Real estate | 2004 |
| SPF Live Ltd | Hospitality | 2023 |
| SPH Holdings (NW) Ltd | Administrative & support | 2024 |
| Spharml Ltd | Information & communication | 2022 |
| Sphere Assets Limited | Real estate | 2021 |
| Sphere Business Services Ltd | Administrative & support | 2017 |
| Sphere Local Limited | Information & communication | 2021 |
| Sphere Social Work Limited | Health & social care | 2015 |
| Spice 08 Limited | Hospitality | 2024 |
| Spice Lounge Huyton Ltd | Hospitality | 2024 |
| Spice Massala Ltd | Hospitality | 2020 |
| Spicy Ginga Ltd | Wholesale & retail | 2026 |
| Spicy HUT Oldham Limited | Hospitality | 2024 |
| Spiderr-Webs Ltd | Wholesale & retail | 2024 |
| Spinal Surgery Solutions Ltd | Health & social care | 2014 |
| Spinning Wheel Records Limited | Arts & recreation | 2019 |
| Splitflux AI Limited | Wholesale & retail | 2025 |
| Sport Hunter Ltd | Professional & scientific | 2024 |
| Sporting Image Limited | Wholesale & retail | 2006 |
| Sports & Corporate Group Travel & Events Ltd | Administrative & support | 2005 |
| Sports & Corporate Group Travel Limited | Administrative & support | 1999 |
| Sports Baze Limited | Wholesale & retail | 2021 |
| Sports Care Limited | Extraterritorial | 2007 |
| Sports Events Logistics Limited | Professional & scientific | 2012 |
| Sports Physio (Holdings) Limited | Other services | 2016 |
| Sports Physio (Retail) Limited | Other services | 2015 |
| Sports Physio (Shaw) Limited | Other services | 2017 |
| Sports Physio (UK) Ltd | Real estate | 2014 |
| Sportsrep Ltd | Wholesale & retail | 2013 |
| Sportstown Limited | Real estate | 2003 |
| Spotland Bridge Logistics Ltd | Transport & logistics | 2019 |
| Spray UK Ltd | Construction | 2025 |
| Sprayawayuk Ltd | Construction | 2019 |
| Spraying Solutions Coatings Ltd | Other services | 2023 |
| Spring Mill Management Company Limited | Households | 2005 |
| Spring Together CIC | Education | 2026 |
| Springboard Supplies Limited | Manufacturing | 2015 |
| Springbrook Properties Ltd | Real estate | 2026 |
| Springfield Corporate Relocations Ltd | Hospitality | 2018 |
| Springfield Court (Wakefield) Management Company Limited | Households | 2017 |
| Springfield Service Station Ltd | Wholesale & retail | 2016 |
| Springhead Stone Company Limited | Real estate | 1999 |
| Springstone Investments Ltd | Construction | 2023 |
| Spryyte Limited | Manufacturing | 2023 |
| SPS Fabrications Limited | Professional & scientific | 2018 |
| SPS Substructure Protection Limited | Construction | 2007 |
| SQ Commerce Hub Ltd | Wholesale & retail | 2026 |
| Squaddie Speed Ltd | Transport & logistics | 2019 |
| Square 1 Studios Ltd | Education | 2010 |
| Square Cherry Productions Limited | Information & communication | 2016 |
| Square One Homes (Warrington) Limited | Construction | 2023 |
| Squirrels Childcare Ltd | Education | 2005 |
| SR Buddy Store Ltd | Wholesale & retail | 2024 |
| SR Essentials Limited | Wholesale & retail | 2022 |
| SR Fashion Ltd | Manufacturing | 2011 |
| SR Maintenance Solutions Limited | Real estate | 2019 |
| SR NW Ltd | Administrative & support | 2019 |
| SRA Property Limited | Real estate | 2016 |
| SRH Property Management Ltd | Real estate | 2025 |
| Srja Holdings Limited | Administrative & support | 2018 |
| SRL (Bead and Blast) Ltd | Professional & scientific | 2018 |
| SRL Group Holdings Limited | Professional & scientific | 2018 |
| SRL Process Systems Ltd | Professional & scientific | 2018 |
| Srns Consultancy Limited | Information & communication | 2022 |
| SRT Takeaways Limited | Hospitality | 2025 |
| SRW Holdco Ltd | Financial services | 2026 |
| SS Properties Group Ltd | Real estate | 2022 |
| SS Property Group Ltd | Real estate | 2023 |
| SS5 Homes Ltd | Real estate | 2026 |
| Ssac Holdings Ltd | Financial services | 2025 |
| Ssch Limited | Health & social care | 2025 |
| SSG Trexyco Ltd | Transport & logistics | 2026 |
| SSK Management Limited | Real estate | 2022 |