| Snip N Clip Barbers Ltd | Other services | 2026 |
| SNM Motors Ltd | Wholesale & retail | 2025 |
| Snooper Limited | Wholesale & retail | 2020 |
| Snowball Films Limited | Information & communication | 2001 |
| SNT Information Limited | Information & communication | 2016 |
| SO Purple Group Limited | Information & communication | 2012 |
| So-U Linen Ltd | Wholesale & retail | 2025 |
| Soapy Stuff Ltd | Wholesale & retail | 2023 |
| Soarify Limited | Wholesale & retail | 2023 |
| Social Bar Ltd | Hospitality | 2026 |
| Social Flair Management Ltd | Professional & scientific | 2025 |
| Social Retail Ltd | Wholesale & retail | 2026 |
| Social Spark Hub Ltd | Professional & scientific | 2023 |
| Sofa SO Good (AR) Ltd | Wholesale & retail | 2025 |
| Sofa-So-Good-Oldham Limited | Wholesale & retail | 2019 |
| Sofas by Saqs Ltd | Other services | 2025 |
| Soffia Properties Ltd | Real estate | 2024 |
| Soffia&Tk Property Maintenance Ltd | Construction | 2026 |
| Soft Origin Ltd | Information & communication | 2025 |
| Softly Jump Ltd | Wholesale & retail | 2025 |
| Software Solutions North West Limited | Information & communication | 1998 |
| Sohal & Gill Ltd | Wholesale & retail | 2023 |
| Sokoni Crafts Ltd | Wholesale & retail | 2014 |
| SOL4U Ltd. | Administrative & support | 2006 |
| Solaiman Properties Ltd | Real estate | 2025 |
| Solar Broker Ltd | Wholesale & retail | 2019 |
| Solar for Everyone Limited | | 2011 |
| Solaris Design Limited | Professional & scientific | 2024 |
| Solderstar Limited | Information & communication | 2000 |
| Sole District Ltd | Wholesale & retail | 2025 |
| Solid Furnishing Ltd | Wholesale & retail | 2025 |
| Solid MMA Manchester Ltd | Arts & recreation | 2025 |
| Solid Surface Distribution Ltd | Wholesale & retail | 2011 |
| Solineclothing Ltd | Wholesale & retail | 2026 |
| Solutionized Ltd | Professional & scientific | 2021 |
| Solutions A1 Limited | Real estate | 2022 |
| SOLUTIONS2PROPERTY Ltd | Hospitality | 2022 |
| Sona Jewellers Oldham Ltd | Wholesale & retail | 2020 |
| Sonali Travels & Finance Ltd | Other services | 2021 |
| Sonar Consultancy Limited | Information & communication | 1994 |
| Sondlekile Limited | Health & social care | 2022 |
| Sonia Asad Properties Ltd | Real estate | 2025 |
| Sonictone Instruments Ltd | Wholesale & retail | 2026 |
| Sonny's Energy Ltd | Construction | 2026 |
| Sonos Developments Ltd | Construction | 2022 |
| Sorella Management Ltd | Information & communication | 2025 |
| Sorella Restaurant Limited | Hospitality | 2019 |
| Sortax Consultancy Services Limited | Professional & scientific | 2018 |
| Sosafe Products Limited | Professional & scientific | 1992 |
| Sotera Group Limited | Professional & scientific | 2025 |
| Sound Drive Ltd | Transport & logistics | 2013 |
| Sourced Recruitment Group Ltd | Administrative & support | 2022 |
| Sourceways Limited | Professional & scientific | 2003 |
| Sourcing Vantage Ltd | Professional & scientific | 2025 |
| South Cheshire Roofing Ltd | Construction | 2025 |
| South Coast Clothing Recycling Limited | Wholesale & retail | 2013 |
| South Essex Roofing Limited | Construction | 2016 |
| South Lake Properties Limited | Real estate | 2024 |
| South Link Developments Limited | Construction | 1989 |
| South North Group Holdings Ltd | Financial services | 2018 |
| South North Investments Ltd | Real estate | 2018 |
| South North Property Management Ltd | Real estate | 2018 |
| Southeast Construction & Roofing Ltd | Construction | 2025 |
| Sovereign Hire Ltd | Administrative & support | 2019 |
| Sovereign House (Cheadle) RTM Company Limited | Households | 2026 |
| Sovereign Wealth Midlands Ltd | Financial services | 2018 |
| Sowerby Street RTM Company Limited | Real estate | 2014 |
| SP Aesthetic Clinic Ltd | Other services | 2025 |
| SP Car & Van Rental Ltd | Administrative & support | 2025 |
| SP Performance Ltd | Wholesale & retail | 2025 |
| SP Thomas Ltd | Education | 2022 |
| Spa-Tech-Us Ltd | Manufacturing | 2016 |
| Spacesun Limited | Professional & scientific | 2022 |
| Spacesun Prevention Limited | Professional & scientific | 2024 |
| Spacesun System Limited | Professional & scientific | 2023 |
| Spacezsolution Ltd | Wholesale & retail | 2025 |
| Spanish Taste Ltd | Hospitality | 2024 |
| Spares-Direct 2015 Ltd | Wholesale & retail | 2015 |
| SPARES4YOU Ltd | Wholesale & retail | 2021 |
| Spark Logistics Limited | Transport & logistics | 2023 |
| Spark Oldham CIC | Health & social care | 2023 |
| Sparkle Cleaning Hands Services Ltd | Administrative & support | 2026 |
| Sparkle Touch Cleaning Limited | Administrative & support | 2023 |
| Sparkle Trade Ltd | Wholesale & retail | 2026 |
| Sparkles & Spotless Cleaning Limited | Administrative & support | 2024 |
| Sparkles Adventure Play Limited | Arts & recreation | 2003 |
| Sparkling Commercial Solutions Limited | Administrative & support | 2025 |
| Sparks Care and Learning Limited | Education | 2025 |
| Sparkstaff Limited | Transport & logistics | 2025 |
| Sparky Unite Ltd | Information & communication | 2025 |
| Spec-Fix UK Online Ltd | Other services | 2012 |
| Specialist Access & Rescue Products Ltd | Manufacturing | 2003 |
| Specialist Coatings (North West) Ltd | Manufacturing | 2020 |
| Specialist Dismantlers Ltd | Wholesale & retail | 2016 |
| Specialty Haus Ltd. | Administrative & support | 2011 |
| Spectre Clinic Ltd | Other services | 2025 |
| Spectre Developments Limited | Professional & scientific | 2024 |
| Spectre Entertainments Ltd | Hospitality | 2021 |
| Spectre Vehicle Security Ltd | Wholesale & retail | 2024 |
| Spectroserv Capital Ltd | Real estate | 2008 |