| Shortify Ltd | Information & communication | 2023 |
| Shortlist Marketing Ltd | Professional & scientific | 2010 |
| Shorts Motor Group Limited | Financial services | 2025 |
| Shortwood Farm Limited | Agriculture & fishing | 2016 |
| Shotdash Ltd | Information & communication | 2022 |
| Shotley Bridge Nursery School Limited | Education | 2003 |
| Shotley Consulting Limited | Professional & scientific | 2019 |
| Shotley Country Park Limited | Hospitality | 2016 |
| Shots Wine Bar Limited | Hospitality | 2003 |
| Shoulder Physio Ltd | Health & social care | 2014 |
| Shouler Holdings Limited | Financial services | 2019 |
| Shout and Holler Limited | Professional & scientific | 2019 |
| Shoutout Technology Ltd | Information & communication | 2021 |
| Shoutsarah Limited | Professional & scientific | 2003 |
| Show HIT Ltd | Information & communication | 2023 |
| Show ME Shoes Limited | Administrative & support | 2016 |
| Show That Glow Tanning Salon Limited | Other services | 2023 |
| Showaddywaddy Limited | Professional & scientific | 1977 |
| Showcrew 24 Ltd | Arts & recreation | 2024 |
| Showground Distribution Park (Management Company) Limited | Professional & scientific | 2013 |
| Showguides Ltd | Professional & scientific | 2023 |
| Showthyme Location Catering Limited | Hospitality | 2021 |
| Showtime Presentations Limited | Professional & scientific | 2001 |
| Showtime Presentations Midlands Limited | Professional & scientific | 2016 |
| Showup Software Ltd | Information & communication | 2026 |
| SHP Accounting Services Ltd | Professional & scientific | 2009 |
| SHP Consulting Ltd | Professional & scientific | 2021 |
| Shpa Ltd | Administrative & support | 2012 |
| Shredall (East Midlands) Limited | Water & waste | 1997 |
| Shredall Ltd | Professional & scientific | 2012 |
| Shree Devi Limited | Real estate | 2016 |
| Shree Restaurants Ltd | Wholesale & retail | 2026 |
| Shree SAI Saburi Ltd | Wholesale & retail | 2026 |
| Shree VJ Ecommerce Ltd | Wholesale & retail | 2025 |
| Shreejai Retail Limited | Wholesale & retail | 2011 |
| Shreeva Services Limited | Professional & scientific | 2025 |
| Shrewsbury V.E. Limited | Other services | 1995 |
| Shrikant Ltd | Real estate | 2024 |
| Shroff Medical Limited | Health & social care | 2014 |
| Shropshire Air Conditioning Limited | Construction | 2021 |
| SHS Builders Ltd | Construction | 2026 |
| Shuchi Ltd | Health & social care | 2024 |
| Shunji Properties Limited | Real estate | 2023 |
| Shunto Company Limited | Transport & logistics | 2023 |
| Shure Group Ltd | Construction | 2025 |
| Shure Property Ltd | Real estate | 2025 |
| Shutters and Security Doors Ltd | Extraterritorial | 2025 |
| SHY Bairns Ltd | Information & communication | 2022 |
| Shyn Properties Limited | Real estate | 2023 |
| Shyne Together Limited | Health & social care | 2011 |
| Shynex Luxury Facilities Ltd | Administrative & support | 2026 |
| SI Active Limited | Professional & scientific | 2009 |
| SI Back Lane Limited | Real estate | 2022 |
| SI Estate Management Ltd | Real estate | 2026 |
| SI Middleton House Limited | Real estate | 2023 |
| SI Norfolk Limited | Real estate | 2022 |
| SI ST Marys Gate Limited | Real estate | 2022 |
| SI Thrussington Limited | Construction | 2022 |
| Siali Ltd | Wholesale & retail | 2025 |
| Sialko Ltd | Wholesale & retail | 2026 |
| Siara Consultancy Limited | Health & social care | 2021 |
| Siara Investments Ltd | Real estate | 2024 |
| Siasshop Limited | Wholesale & retail | 2024 |
| Sibo Enterprises Ltd | Hospitality | 2020 |
| Sibu Fish and Meat Supply Nottingham Ltd | Wholesale & retail | 2023 |
| SID Sottung Academy Limited | Education | 2015 |
| Sida Holdings UK Limited | Financial services | 2025 |
| Sidedoor Studio Ltd | Information & communication | 2026 |
| Sidh Limited | Wholesale & retail | 2017 |
| Sidhar Holdings Limited | Financial services | 2021 |
| Sidhu Property Investments Ltd | Real estate | 2026 |
| Sidi BOU Ltd | Wholesale & retail | 2022 |
| Sidi Sourcing Ltd | Wholesale & retail | 2015 |
| Sidney Hackett Limited | Agriculture & fishing | 1952 |
| Sidona Eatery Ltd | Wholesale & retail | 2024 |
| Sidona Holdings Ltd | Real estate | 2024 |
| Sidro Limited | Other services | 2023 |
| Sieben Recruitment Ltd | Administrative & support | 2018 |
| Sierra International Ltd | Health & social care | 2019 |
| Sieveservices Ltd | Professional & scientific | 2022 |
| Sigaram Holdings Ltd | Real estate | 2023 |
| Sigfloor Holdings Limited | Financial services | 2025 |
| Sight Tech Foundation CIC | Public administration | 2022 |
| Sightstone Consultancy Group Ltd | Professional & scientific | 2021 |
| Sigma 360 Ltd | Wholesale & retail | 2018 |
| Sigma Dental Limited | Health & social care | 2006 |
| Sigma Imports & Exports Limited | Wholesale & retail | 1985 |
| Sigma Interiors & Flooring Ltd | Construction | 2017 |
| Sigma Kitchens Ltd | Wholesale & retail | 2015 |
| Sigma One Group Limited | Real estate | 2024 |
| Sigma One Restaurants Ltd | Hospitality | 2025 |
| Sigma Safety Ltd | Professional & scientific | 2025 |
| Sigmh Garden Services Ltd | Administrative & support | 2025 |
| Sign Solutions Midlands Limited | Administrative & support | 2003 |
| Sign@Ture Moves Ltd | Arts & recreation | 2023 |
| Signature Aesthetics (Nottingham) Ltd | Other services | 2026 |
| Signature Bathrooms and Tiling Limited | Construction | 2017 |
| Signature Bliss Ltd | Hospitality | 2025 |
| Signature Building & Developments Limited | Construction | 2026 |
| Signature Building Services Limited | Construction | 2009 |