| Safety of AI Limited | Information & communication | 2025 |
| Safety People Consulting Ltd | Education | 2018 |
| Safety Signs World Limited | Construction | 2016 |
| Safeuk Limited | Health & social care | 2023 |
| Safeway Security Ltd | Administrative & support | 2008 |
| Safewear Limited | Wholesale & retail | 2000 |
| Saffa Designs Limited | Wholesale & retail | 2018 |
| Saffa Web Design Ltd | Information & communication | 2022 |
| Saffron & Gray Ltd | Professional & scientific | 2020 |
| Saffron Networking Limited | Information & communication | 2010 |
| Saffron Shades Limited | Other services | 2018 |
| Saffron Spice Ltd | Hospitality | 2020 |
| Saffrons of York Limited | Wholesale & retail | 2008 |
| Safi Roho Ltd | Construction | 2025 |
| Safmaal Ltd | Wholesale & retail | 2023 |
| Safoam Limited | Health & social care | 2021 |
| Saga Irreal UK Ltd | Real estate | 2025 |
| Sagacious Contracting Ltd | Construction | 2018 |
| Sage Barras Homes Limited | Real estate | 2021 |
| Sage Care Limited | Health & social care | 1996 |
| Sage Care Servco Ltd | Professional & scientific | 2019 |
| Sage Therapy Centre Limited | Real estate | 2019 |
| Sage Translate Ltd | Professional & scientific | 2025 |
| Saggu Logistics Ltd | Transport & logistics | 2021 |
| Saglam Painting & Decorating Ltd | Construction | 2019 |
| SAH ED Tech Limited | Information & communication | 2024 |
| SAH Electrical Contractors Limited | Construction | 2012 |
| Sahaba Food Store Ltd | Wholesale & retail | 2023 |
| Sahar Haven Ltd | Wholesale & retail | 2025 |
| Sahara Food Store Ltd | Wholesale & retail | 2025 |
| Sahara Recruitment Limited | Administrative & support | 2017 |
| Sahavi Ltd | Hospitality | 2023 |
| Sahib Builders Ltd | Construction | 2022 |
| Sahin Barber Ltd | Other services | 2023 |
| Sahoma Ltd. | Real estate | 2021 |
| SAI & Partners Ltd | Health & social care | 2014 |
| SAI OM Limited | Health & social care | 2000 |
| Saifee Investments Ltd | Real estate | 2022 |
| Saifee Limited | Information & communication | 2015 |
| Sail Construction Ltd | Construction | 2020 |
| Sail Smoothly Limited | Hospitality | 2012 |
| Sailaway Boat Centre Ltd | Manufacturing | 2018 |
| Sailmakers (Suffolk) Limited | Administrative & support | 2024 |
| Saima & Co Limited | Health & social care | 2022 |
| Saint Anns Sheet Metal Company Limited | Manufacturing | 1998 |
| Saint Joseph Restorations Ltd | Construction | 2025 |
| Saint Patrick Properties Ltd | Real estate | 2020 |
| Saint Properties (Nottingham) Limited | Real estate | 2003 |
| Saint Werburgh Ltd | Professional & scientific | 2021 |
| Saint's Family Leisure Co. Ltd | Wholesale & retail | 2026 |
| Saiu Luminita Limited | Information & communication | 2016 |
| Sajig Ltd | Health & social care | 2023 |
| Sajjad Hussain Ltd | Professional & scientific | 2014 |
| Sajko Ltd | Transport & logistics | 2024 |
| Sajrot Ltd | Wholesale & retail | 2026 |
| Sajw Ltd | Administrative & support | 2024 |
| SAK Maintenance Ltd | Construction | 2018 |
| Saka's House Ltd | Wholesale & retail | 2024 |
| Saki Electronics Ltd | Wholesale & retail | 2025 |
| Sakura 88 Limited | Hospitality | 2021 |
| Sakura Eatery Limited | Hospitality | 2025 |
| SAL Advisory Limited | Other services | 2022 |
| SAL Building Ltd | Construction | 2023 |
| Salaam and Mashreq Properties Ltd | Other services | 2017 |
| Salaam Shawarma & Grill Ltd | Hospitality | 2026 |
| Salad Days Notts Ltd | Wholesale & retail | 2020 |
| Salah Advisory Ltd | Professional & scientific | 2026 |
| Salah Property 1 Ltd | Real estate | 2026 |
| Salama Fikira Group Limited | Professional & scientific | 2019 |
| Salama Fikira International (UK) Limited | Professional & scientific | 2019 |
| Salama Services Ltd | Professional & scientific | 2022 |
| Salamanda Tandem | Arts & recreation | 2000 |
| Salear Property Limited | Real estate | 2026 |
| Saleem and Sons Best Ltd | Hospitality | 2022 |
| Saleem Qayum Holdings Ltd | Financial services | 2025 |
| Saleem S Medical Ltd | Health & social care | 2026 |
| Saleo Properties Limited | Real estate | 2022 |
| Sales Business Recruitment Limited | Administrative & support | 2022 |
| Sales&Marketing Janusz Pichalski Ltd | Construction | 2024 |
| SALES360 Ltd | Professional & scientific | 2024 |
| Salford Care & Support Services Ltd | Health & social care | 2024 |
| Sali Teams Ltd | Real estate | 2021 |
| Saliahara Ltd | Wholesale & retail | 2025 |
| Saligo Ltd | Real estate | 2017 |
| Saliha Trade Limited | Wholesale & retail | 2024 |
| Salina Productions Limited | Information & communication | 2023 |
| Salinas Corporate Finance Ltd | Financial services | 2015 |
| Salinas Inc Ltd | Financial services | 2015 |
| Salinas Property Ltd | Extraterritorial | 2017 |
| Salisbury Property Ltd | Real estate | 2024 |
| Salisbury V.E. Limited | Other services | 1995 |
| Salkay Ltd | Real estate | 2019 |
| Sallis Healthcare Limited | Manufacturing | 1946 |
| Salman Medics Limited | Health & social care | 2025 |
| Salmon Street Property Limited | Real estate | 2021 |
| Salokazi Limited | Health & social care | 2019 |
| Salon Branded Ltd | Other services | 2021 |
| Salon Electricals Limited | Other services | 2015 |
| Salon Whisper Ltd | Information & communication | 2026 |
| Salop Deliveries Limited | Hospitality | 2022 |