| S2P Limited | Information & communication | 2014 |
| S2P Property Limited | Real estate | 2017 |
| S8 Contractors Limited | Construction | 2026 |
| S@Feroute Ltd | Administrative & support | 2020 |
| SA & JF Whitby Property Management Ltd | Real estate | 2020 |
| SA Connect Ltd | Information & communication | 2019 |
| SA Corporate Ltd | Hospitality | 2017 |
| SA Dental Services Ltd | Health & social care | 2023 |
| SA Ghana Events Ltd | Hospitality | 2018 |
| SA Global Event Crews Ltd | Construction | 2022 |
| SA Investments & Holdings Ltd | Real estate | 2000 |
| SA Pool Systems Limited | Construction | 2010 |
| SA Pools Services Limited | Construction | 2013 |
| SA Practice Limited | Health & social care | 2014 |
| SA Property Midlands Limited | Real estate | 2025 |
| SA Short Property Ltd | Real estate | 2025 |
| SAA Event Services Ltd | Administrative & support | 2021 |
| SAA Global Ltd | Hospitality | 2024 |
| Saaf Education Ltd | Professional & scientific | 2016 |
| Saaf Finance Ltd | Professional & scientific | 2011 |
| Saaf Payroll Ltd | Administrative & support | 2020 |
| Saaf Supply Ltd | Administrative & support | 2017 |
| Saaf Tech Ltd | Information & communication | 2022 |
| Saagar Restaurant Limited | Hospitality | 2002 |
| Saans Life UK Limited | Health & social care | 2023 |
| Saashy Limited | Public administration | 2023 |
| SAB Content Ltd | Information & communication | 2024 |
| SAB KUJ 13 Ltd | Real estate | 2021 |
| SAB Security Services Limited | Administrative & support | 2021 |
| Sabha Foods Ltd | Wholesale & retail | 2024 |
| SABKUJ1313 Limited | Real estate | 2023 |
| Sabr Revops Consulting Limited | Professional & scientific | 2026 |
| Sabrina Capitalstyle Ltd | Wholesale & retail | 2025 |
| Saby Style Ltd | Wholesale & retail | 2025 |
| SAC Consultancy Ltd | Professional & scientific | 2025 |
| Saccounting Ltd | Professional & scientific | 2018 |
| Sacom UK Limited | Construction | 2011 |
| Sacred Bears Ltd | Wholesale & retail | 2025 |
| Sacred Garden Limited | Wholesale & retail | 2025 |
| Sacred Land Tours Ltd | Administrative & support | 2023 |
| Sacredconnections Ltd | Administrative & support | 2025 |
| Sadafconsulting Ltd | Professional & scientific | 2026 |
| Sadhanisha Limited | Professional & scientific | 2024 |
| Sadiecare Ltd | Administrative & support | 2025 |
| Sadler Accountants Limited | Professional & scientific | 2025 |
| Sadlergates Catering Ltd | Hospitality | 2017 |
| Sadozai Group of Industries (SGI) Ltd | Health & social care | 2025 |
| SAF Home Realtors Limited | Real estate | 2024 |
| SAF Mart Ltd | Wholesale & retail | 2025 |
| SAF Motors Ltd | Wholesale & retail | 2020 |
| SAF Plumbing & Heating Limited | Construction | 2013 |
| SAF Property Management Limited | Real estate | 2021 |
| Safdar Financial Services Ltd | Professional & scientific | 2021 |
| Safe & Steadfast Care Ltd | Health & social care | 2025 |
| Safe 2 USE Limited | Professional & scientific | 2012 |
| Safe and Sound Security Services Ltd | Administrative & support | 2008 |
| Safe Car Breakers Ltd | Wholesale & retail | 2020 |
| Safe Comply Ltd | Professional & scientific | 2025 |
| Safe Consultancy Services Ltd | Administrative & support | 2012 |
| Safe Dimensions Limited | Information & communication | 2007 |
| Safe Hands Audio Limited | Arts & recreation | 2012 |
| Safe Hands Removals Ltd | Transport & logistics | 2019 |
| Safe Harbor Mental Health & Housing CIC | Hospitality | 2026 |
| Safe Haven (Childrens Homes) Ltd | Health & social care | 2022 |
| Safe Haven Accommodation Ltd | Health & social care | 2013 |
| Safe Haven Accommodation North East Ltd | Health & social care | 2025 |
| Safe Haven Alternative Provision of Excellence Ltd | Education | 2023 |
| Safe Haven Childrens Residential Ltd | Health & social care | 2025 |
| Safe Haven Families First Ltd | Health & social care | 2025 |
| Safe Haven Properties Ltd | Real estate | 2023 |
| Safe Haven Property Holdings Ltd | Real estate | 2023 |
| Safe Haven Property Investments Ltd | Real estate | 2025 |
| Safe Haven Support Care & Education Group Ltd | Financial services | 2023 |
| Safe Places Organisation Community Interest Company | Education | 2014 |
| Safe Roots Housing CIC | Hospitality | 2019 |
| Safe Routes Logistics Ltd | Other services | 2021 |
| Safe Sanctuary Living Ltd | Health & social care | 2020 |
| Safe Secure Spaces Limited | Extraterritorial | 2018 |
| Safe Solutions Fire Doors Ltd | Professional & scientific | 2023 |
| Safe Soul Care Ltd | Health & social care | 2026 |
| Safe Space - Notts CIC | Education | 2026 |
| Safe Space Accommodation Ltd | Hospitality | 2025 |
| Safe Space Therapy Limited | Health & social care | 2018 |
| Safe Spaces(Midlands) Ltd | Public administration | 2025 |
| Safebridge Support Ltd | Health & social care | 2025 |
| Safeguard Asbestos Limited | Construction | 2025 |
| Safeguard Heating Services Ltd | Construction | 2021 |
| Safeguarding Monitor Limited | Information & communication | 2017 |
| Safeguarding Solutions Limited | Health & social care | 2011 |
| Safejourney TM Ltd | Construction | 2024 |
| Safekraft Ltd | Arts & recreation | 2025 |
| Safemind Brotherhood CIC | Education | 2026 |
| Safesteps Physiotherapy Ltd | Other services | 2026 |
| Safetex UK Ltd | Wholesale & retail | 2016 |
| Safetrackuk Ltd | Wholesale & retail | 2025 |
| Safety Aide Holdings Ltd | Professional & scientific | 2026 |
| Safety Aide Ltd | Professional & scientific | 2010 |
| Safety Case Consultants Limited | Professional & scientific | 2020 |
| Safety Measures Limited | Administrative & support | 1995 |
| Safety Measures WEX Limited | Education | 2017 |