| Engineering and Mechanical Resources Limited | Professional & scientific | 2014 |
| Engineering Construction Services Limited | Professional & scientific | 2024 |
| Engineering Surveying Ltd | Professional & scientific | 2025 |
| Engineering Systems (Nottm) Limited | Manufacturing | 2003 |
| Engineering Witness Ltd | Professional & scientific | 2019 |
| Engines Factory Ltd | Manufacturing | 2016 |
| Engire Limited | Energy | 2018 |
| English Rose Estate Agents Limited | Real estate | 2018 |
| Englistaan Limited | Education | 2020 |
| Englsos Ltd | Wholesale & retail | 2025 |
| Engrein Worldwide Ltd | Information & communication | 2026 |
| Enhance 2018 Limited | Other services | 2018 |
| Enhance Aesthetics UK Limited | Health & social care | 2008 |
| Enhance Sports Massage Limited | Health & social care | 2023 |
| Enhance Wealth Management Co., Ltd | Real estate | 2025 |
| Enhanced by Elsie Ltd | Health & social care | 2023 |
| Enhanced Energy Efficiency Enterprises Limited | Professional & scientific | 2016 |
| Enigma Developments Ltd. | Construction | 2003 |
| Enigma Properties Ltd | Real estate | 2001 |
| Enigma Service & Maintenance Ltd | Administrative & support | 2014 |
| Enigma Trading Ltd | Wholesale & retail | 2020 |
| Enlighten Global Consulting Ltd | Financial services | 2014 |
| Enlightened Consultancy Limited | Professional & scientific | 2016 |
| ENM Consulting Ltd | Professional & scientific | 2020 |
| Enola Remaps Ltd | Wholesale & retail | 2024 |
| Enquote Marketing Ltd | Information & communication | 1998 |
| Enray Finn Developments Ltd | Construction | 2025 |
| Enrich International Limited | Professional & scientific | 2017 |
| Enroll Ltd | Wholesale & retail | 2018 |
| Ensco 1084 Limited | Financial services | 2014 |
| Ensco 829 Limited | Professional & scientific | 2011 |
| Ensco 969 Limited | Professional & scientific | 2013 |
| Ensco Financial Planning Limited | Financial services | 2014 |
| Ensek Holdings Limited | Information & communication | 2017 |
| Ensek Ltd | Information & communication | 2010 |
| Ensign Leadership Training Ltd | Education | 2022 |
| Ensign Mortgages and Investments Limited | Financial services | 2003 |
| Enstroga Ltd | Energy | 2015 |
| Ensure Group Ltd | Construction | 2019 |
| ENT Academy CIC | Education | 2022 |
| ENT Derbyshire Ltd | Health & social care | 2024 |
| ENT Health Limited | Health & social care | 2012 |
| ENT Masterclass Limited | Health & social care | 2008 |
| Enter Properties Ltd | Real estate | 2020 |
| Enterprise Educators Global Limited | Education | 2017 |
| Enterprise Educators UK | Education | 2010 |
| Enterprise Loans East Midlands | Financial services | 2008 |
| Enterprise Loans EM Meif CIP Limited | Financial services | 2017 |
| Enterprise Loans EM Meif GP Limited | Financial services | 2017 |
| Enterprise Loans EM Meif II CIP Limited | Financial services | 2024 |
| Enterprise Loans EM Meif II GP Limited | Financial services | 2024 |
| Enterprise Software Systems Limited | Extraterritorial | 1997 |
| Enterprise Tech Group (ETG) Limited | Information & communication | 2018 |
| Entex Springs Limited | Manufacturing | 1995 |
| Enthusiast Ltd | Wholesale & retail | 2024 |
| Entirety Creative Limited | Wholesale & retail | 2011 |
| Entity Construction Ltd | Construction | 2023 |
| Entity Motors Limited | Wholesale & retail | 2025 |
| Entolab Ltd | Manufacturing | 2021 |
| Entrance CDS Ltd | Manufacturing | 2019 |
| Envi-Lawns Ltd | Administrative & support | 2016 |
| Enviroair Services Limited | Construction | 2014 |
| Envirobuildtek Limited | Construction | 2011 |
| Envirocare Site Services Limited | Professional & scientific | 2016 |
| Envirofy Limited | Professional & scientific | 2025 |
| Environmental and Energy Performance Consultants Limited | Professional & scientific | 2009 |
| Environmental Phones Ltd | Information & communication | 2011 |
| Environpro Limited | Manufacturing | 2025 |
| Envirosmart Energy Limited | Construction | 2012 |
| Envirosuite UK Limited | Professional & scientific | 2018 |
| Envirosys Limited | Water & waste | 2012 |
| Envirup Limited | Manufacturing | 2002 |
| Envision Consulting Ltd | Professional & scientific | 2003 |
| Envision Education Consultant Ltd | Education | 2023 |
| Envision Healthcare Ltd | Health & social care | 2020 |
| Envision Training Ltd | Extraterritorial | 2011 |
| Envo Design Limited | Professional & scientific | 2024 |
| Envo Electrical Limited | Construction | 2022 |
| Envoy Human Capital Limited | Administrative & support | 2016 |
| Envvy Limited | Manufacturing | 2022 |
| Envy Arundel Ltd | Other services | 2017 |
| Envyrion Ltd | Information & communication | 2024 |
| ENZ Services Ltd | Transport & logistics | 2023 |
| Enzo Drive Limited | Administrative & support | 2023 |
| EOA Cleaning Services Limited | Administrative & support | 2025 |
| EOE Holdings Ltd | Financial services | 2020 |
| EOL Property Maintenance Ltd | Construction | 2026 |
| Eomen Ltd | Wholesale & retail | 2026 |
| EOP Recruitment Ltd | Administrative & support | 2025 |
| EOS (N.W) Ltd | Wholesale & retail | 2022 |
| Eoslightinguk Ltd | Wholesale & retail | 2024 |
| EOT Diamond Cleaning Ltd | Administrative & support | 2026 |
| EP Circularity Ventures Limited | Professional & scientific | 2026 |
| EP Corporate Ventures Limited | Professional & scientific | 2026 |
| EP Talent Ltd | Administrative & support | 2024 |
| EP UK Group Limited | Manufacturing | 2024 |
| EPA Associates Ltd | Education | 2020 |
| EPB Homes Ltd | Real estate | 2018 |
| EPC (Midlands) Limited | Professional & scientific | 2005 |
| EPC Asap Ltd | Real estate | 2017 |