| SPC Norfolk Ltd | Professional & scientific | 2018 |
| SPD Landscapes Ltd | Administrative & support | 2022 |
| SPD Storage Ltd | Transport & logistics | 2020 |
| Speak Well With Willpower CIC | Education | 2022 |
| Spear Teaching Ltd | Education | 2025 |
| Spearfield Holdings Limited | Financial services | 2025 |
| Special Delivery Accessories Ltd | Administrative & support | 2016 |
| Special Design Studio Ltd | Professional & scientific | 2008 |
| Special Education Solutions Ltd | Education | 2022 |
| Special Needs Enterprises (Norfolk) Limited | Health & social care | 1989 |
| Specialist Building Supplies Limited | Wholesale & retail | 2013 |
| Specialist Conservatory Roof Systems (Norfolk) Ltd | Construction | 2018 |
| Specialist Control Systems Ltd | Manufacturing | 2016 |
| Specialist Education Services (Topco) Limited | Professional & scientific | 2021 |
| Specialist Inspection Services Limited | Construction | 2023 |
| Specialist Spinal Surgery Anaesthesia Ltd | Health & social care | 2019 |
| Specialist Toughened Glass Ltd. | Manufacturing | 1998 |
| Specialist Welding Services East Ltd | Manufacturing | 2025 |
| Speclearn Academy Ltd | Construction | 2023 |
| Specops.Live Ltd | Arts & recreation | 2026 |
| Spectrum Music & Books Ltd | Wholesale & retail | 2015 |
| Spedo (UK) Limited | Manufacturing | 1991 |
| Speech Bubble Marketing Limited | Wholesale & retail | 2012 |
| Speed 7714 Limited | Construction | 1999 |
| Speed Accounting Limited | Professional & scientific | 2008 |
| Speedrl Limited | Arts & recreation | 2020 |
| Speedwell Accounting Services Limited | Professional & scientific | 2006 |
| Speedy Stamps Limited | Wholesale & retail | 2006 |
| Speedy Windows Limited | Construction | 2012 |
| Spelman 2014 Limited | Professional & scientific | 2014 |
| Spencer Builders Norfolk Limited | Construction | 2025 |
| Spencer Daniels Building & Maintenance Ltd | Construction | 2013 |
| Spencer Heating & Plumbing Ltd | Construction | 2026 |
| Spencer's Car Sales Limited | Wholesale & retail | 2006 |
| Spencer's MOT & Service Centre Limited | Wholesale & retail | 2015 |
| Spencer's Properties Limited | Construction | 2016 |
| Spennyg's Limited | Administrative & support | 2004 |
| Spensational Lighting Ltd | Information & communication | 2019 |
| Speot Limited | Administrative & support | 2022 |
| SPG Data Limited | Information & communication | 2004 |
| SPH Housing Ltd | Real estate | 2021 |
| Spice Fusion Stoke Limited | Hospitality | 2017 |
| Spice HUT Bolton Ltd | Hospitality | 2022 |
| Spice Invaders Tamworth Limited | Hospitality | 2015 |
| Spice Kitchen Stevenage Limited | Hospitality | 2016 |
| Spice Lounge (Norwich) Ltd | Hospitality | 2007 |
| Spice Lounge Birmingham Ltd | Hospitality | 2020 |
| Spice of Llanberis Restaurant Limited | Hospitality | 2016 |
| Spice of Pwllheli Limited | Hospitality | 2019 |
| Spice Village (LYE) Ltd | Hospitality | 2019 |
| Spice Xpress Norwich Limited | Wholesale & retail | 2022 |
| Spiced Lotus Ltd | Hospitality | 2019 |
| Spicexpress Property Limited | Real estate | 2025 |
| Spicy Badshah Ltd | Hospitality | 2014 |
| Spicy COV Ltd | Wholesale & retail | 2015 |
| Spicy Ltd | Hospitality | 2017 |
| Spike Online Ltd | Professional & scientific | 2024 |
| Spikey Bush Limited | Wholesale & retail | 2021 |
| Spill Tea Limited | Wholesale & retail | 2023 |
| Spindle Productions Ltd | Information & communication | 2012 |
| Spine Secure Services Limited | Wholesale & retail | 2024 |
| Spinks & Williams Limited | Transport & logistics | 2018 |
| Spinners Court (Stalham) Residents Association Limited | Real estate | 1988 |
| Spiral N Dogs Limited | Extraterritorial | 2023 |
| Spiral Subsea Ltd | Mining & quarrying | 2020 |
| Spire Building and Renovations Limited | Construction | 2019 |
| Spire Cleaning Services Ltd | Administrative & support | 2019 |
| Spire IT Hardware Ltd | Wholesale & retail | 2026 |
| Spire Property Consultants Limited | Real estate | 2017 |
| Spire Safety Engineering Ltd | Professional & scientific | 2026 |
| Spire Solicitors LLP | | 2013 |
| Spiregrass Square Residents Management Company Limited | Households | 2022 |
| Spirit House Films Ltd | Information & communication | 2021 |
| Spirit Motorsport Ltd | Arts & recreation | 2010 |
| Spirits Wholesale Ltd | Wholesale & retail | 2022 |
| Spitalhatch Management Company Limited | Households | 2007 |
| Spitfire Bodycentre Limited | Wholesale & retail | 2020 |
| Spitfire Performance Ltd | Arts & recreation | 2016 |
| Spixworth Management Company Ltd | Households | 2018 |
| Spixworth Pharmacy Limited | Wholesale & retail | 2003 |
| Spixworth Taxis Limited | Transport & logistics | 2019 |
| Spizzystore Ltd | Wholesale & retail | 2025 |
| SPL Supply Chain Solutions Limited | Administrative & support | 2014 |
| SPL22 Limited | Real estate | 2022 |
| Splendid Scrimmage Limited | Information & communication | 2014 |
| Split Leaps Gymnastics Ltd | Arts & recreation | 2019 |
| Split Screen Ice Cream Co Ltd | Extraterritorial | 2025 |
| Split Signal Ltd | Professional & scientific | 2025 |
| SPM Consulting & Management Limited | Financial services | 2011 |
| SPM Dental Equipment Engineers Ltd | Manufacturing | 2010 |
| Spokes Coffee Ltd | Hospitality | 2021 |
| Spon END Limited | Wholesale & retail | 2012 |
| Spondyloarthritis Training and Education Spate (UK) Ltd | Education | 2018 |
| Spoon Cake Limited | Hospitality | 2013 |
| Spoon of Doom Ltd | Wholesale & retail | 2016 |
| Spooners Rise (Wymondham) Management Company Ltd | Households | 2006 |
| Spork Digital Limited | Information & communication | 2011 |
| Sportlink Specialist Sports Limited | Wholesale & retail | 2001 |
| Sportquest Holidays Ltd | Administrative & support | 2003 |
| Sports Data Analysis Ltd | Arts & recreation | 2019 |