| Sound Sleep Norwich Ltd | Wholesale & retail | 2025 |
| Soundings (Consultation) Limited | Professional & scientific | 2007 |
| Soundsleep Limited | Other services | 1992 |
| Soundyard CIC | Information & communication | 2022 |
| Soup Creations Ltd | Information & communication | 2025 |
| Soupear Limited | Hospitality | 2022 |
| Sourcetm Ltd | Public administration | 2024 |
| Sourcing Consultants Ltd | Professional & scientific | 2013 |
| SOURCING4EXPORTS Ltd | Wholesale & retail | 2024 |
| SOURCING4U Limited | Wholesale & retail | 2004 |
| South Brink Developments Ltd | Professional & scientific | 2007 |
| South East Coffee Company Limited | Wholesale & retail | 2012 |
| South Farm Engineering Limited | Manufacturing | 2002 |
| South Grantham Energy Centre Limited | Energy | 2024 |
| South Hampstead (AR) Limited | Real estate | 2020 |
| South Leicester Memorial Park Ltd | Other services | 2014 |
| South London Hair Services Limited | Other services | 2019 |
| South Norfolk Developments Limited | Construction | 2001 |
| South Norfolk Electrical Ltd | Construction | 2019 |
| South Norfolk Healthcare C.I.C. | Health & social care | 2010 |
| South Norfolk Heating Ltd | Construction | 2022 |
| South Norfolk Trading Ltd | Wholesale & retail | 2012 |
| South Park Project Limited | Real estate | 2021 |
| South Suffolk Holding Company Limited | Professional & scientific | 2024 |
| South Wales Cafes Ltd | Hospitality | 2019 |
| South Walsham Properties Limited | Administrative & support | 2002 |
| Southacre Promotions Limited | Wholesale & retail | 1999 |
| Southampton Recruitment Services Limited | Administrative & support | 2012 |
| Southend Pharma Ltd | Wholesale & retail | 2025 |
| Southern Aircraft Consultancy Limited | Professional & scientific | 2010 |
| Southern Marine Ltd | Administrative & support | 2015 |
| Southern Reach Limited | Real estate | 2014 |
| Southfort Holdings Limited | Real estate | 2023 |
| Southgate Capital Corp Ltd | Professional & scientific | 2025 |
| Southmere Place Management Company Limited | Households | 2024 |
| Southpark Estates Limited | Real estate | 1985 |
| Southsea Cycles Limited | Wholesale & retail | 2015 |
| Southwell Creative Studios Ltd | Professional & scientific | 2022 |
| Southwell Ltd | Real estate | 2025 |
| Southwest Horseboxes Ltd | Manufacturing | 2018 |
| Southwold Gallery Limited | Wholesale & retail | 2005 |
| Southworth Green Associates Limited | Professional & scientific | 2002 |
| Souvlaki ALL Day Ltd | Hospitality | 2021 |
| Sovereign Garage Doors Ltd. | Construction | 2021 |
| Sovereign Professional Services (East Anglia) Ltd | Professional & scientific | 2019 |
| SP Auto Car Sales Ltd | Extraterritorial | 2018 |
| SP Carrick Ltd | Professional & scientific | 2010 |
| SP Conway Ltd | Construction | 2013 |
| SP Plumbing & GAS Heating Ltd | Construction | 2017 |
| Spa Avondale Road Ltd | Real estate | 2021 |
| Spa Christophi LLP | | 2008 |
| Spa Euston Road Ltd | Real estate | 2017 |
| Spa Holdings 10 Ltd | Real estate | 2021 |
| Spa Holdings 18 Ltd | Real estate | 2021 |
| Spa Holdings 2.1 Ltd | Real estate | 2021 |
| Spa Holdings 6 Ltd | Real estate | 2018 |
| Spa Holdings 7 Ltd | Real estate | 2018 |
| Spa Holdings 8 Ltd | Real estate | 2021 |
| Spa Holdings 9 Ltd | Real estate | 2021 |
| Spa Holdings Group Ltd | Administrative & support | 2017 |
| Spa Marine Crescent Ltd | Real estate | 2021 |
| Spa Marine Parade Ltd | Real estate | 2017 |
| Spa Prosper House Ltd | Real estate | 2017 |
| Spa Thorpe Road Ltd | Real estate | 2017 |
| Space Events (Norwich) Limited | Hospitality | 2023 |
| Spainter Ltd | Construction | 2023 |
| Spalding & Tunnicliffe Properties Ltd | Real estate | 2021 |
| Spalding Brickwork Ltd | Construction | 2023 |
| Spanfax Limited | Professional & scientific | 1991 |
| Spark Code Limited | Information & communication | 2020 |
| Spark Films Limited | Arts & recreation | 1991 |
| Spark Investments Limited | Financial services | 2024 |
| Spark.Com.Ng Limited | Other services | 2013 |
| Sparka Future Collective Ltd | Professional & scientific | 2019 |
| Sparkes Electrical Ltd | Construction | 2017 |
| Sparkle Norwich Ltd | Administrative & support | 2022 |
| Sparkle Ovens Limited | Administrative & support | 2010 |
| Sparkling Cheese Ltd | Hospitality | 2022 |
| Sparkling Peach Limited | Information & communication | 2020 |
| Sparkling Success Ltd | Hospitality | 2019 |
| Sparkly Solutions Ltd | Administrative & support | 2020 |
| Sparkly Squid Limited | Information & communication | 2024 |
| SPARKS2U Ltd | Construction | 2019 |
| Sparksight Ltd | Health & social care | 2025 |
| Sparkyjoe Electrical Ltd | Construction | 2020 |
| Sparrow Blue Ltd | Hospitality | 2024 |
| Sparrow Green (Holdings) Ltd | Financial services | 2014 |
| Sparrow Green Group Ltd | Financial services | 2020 |
| Sparrow Green Ltd | Real estate | 2016 |
| Sparrow Hall Norfolk Limited | Financial services | 2021 |
| Sparrow Red Ltd | Hospitality | 2024 |
| Sparrow Roofing Norfolk Limited | Construction | 2025 |
| Sparrowhawk Energy (Operations) Limited | Energy | 2021 |
| Sparrowhawk Energy Limited | Energy | 2019 |
| Spartan Delta Management Ltd | Financial services | 2022 |
| Spartan Property Ltd | Real estate | 2020 |
| SPB UPS & DC Power Services Limited | Manufacturing | 2011 |
| SPC (Norwich) Limited | Professional & scientific | 2007 |
| SPC Aviation Limited | Transport & logistics | 2007 |
| SPC Holdings Limited | Professional & scientific | 1994 |