| S.C Construction Norfolk Limited | Construction | 2024 |
| S.Crosby Services Ltd | Manufacturing | 2018 |
| S.E.B.S Management Limited | Real estate | 2001 |
| S.Folley Engineering Services Ltd | Professional & scientific | 2012 |
| S.G. Consultancy Limited | Professional & scientific | 2012 |
| S.M.L. Kingston Mrics Limited | Financial services | 2008 |
| S.R.Gray Properties Ltd | Real estate | 2016 |
| S.T.L. Realty Ltd | Real estate | 2023 |
| S0C13TY Ltd | Information & communication | 2020 |
| S2 Productions Ltd | Information & communication | 2021 |
| S2 Roofing Ltd | Construction | 2014 |
| S3 Solutions Limited | Construction | 2023 |
| S4OFFSHORE Ltd | Administrative & support | 2015 |
| S7 Labs Ltd | Information & communication | 2026 |
| SA Associates Norwich Limited | Professional & scientific | 2017 |
| SA Electrical (Norfolk) Ltd | Construction | 2012 |
| Saak Enterprises Limited | Manufacturing | 2019 |
| Saari Consulting Ltd | Information & communication | 2022 |
| Saari Ltd. | Information & communication | 2013 |
| Saatsaa Limited | Wholesale & retail | 2017 |
| SAB Imaging Solutions Ltd | Health & social care | 2019 |
| Saba IT Consultancy Ltd | Information & communication | 2017 |
| Sabatino Cometa Limited | Manufacturing | 2023 |
| Sabena Marine Ltd | Manufacturing | 2019 |
| Saber Tyres Limited | Wholesale & retail | 2017 |
| Sabih K. Limited | Education | 2017 |
| Sablefell Ltd | Information & communication | 2026 |
| Sablistech Ltd | Information & communication | 2011 |
| Sabotage Self-Sabotage Ltd | Information & communication | 2023 |
| SAC Restoration Ltd | Construction | 2016 |
| Sacks Consulting Ltd | Professional & scientific | 2011 |
| Sacred Eagle Book Publishing Limited | Arts & recreation | 2017 |
| SAD Automotive Ltd. | Wholesale & retail | 2023 |
| SAD Autos Limited | Wholesale & retail | 2025 |
| Saddlewood Property Ltd | Real estate | 2017 |
| Sadie's Florist Ltd | Wholesale & retail | 2018 |
| Sadler Enterprises Ltd | Wholesale & retail | 2025 |
| Safari Shack Cafe Ltd | Hospitality | 2026 |
| Safe at Home C.I.C. | Financial services | 2022 |
| Safe City Security Systems Ltd | Administrative & support | 2010 |
| Safe Dispenser Ltd | Information & communication | 2005 |
| Safe Hands Partnership Limited | Health & social care | 2015 |
| Safe Hive Ltd | Construction | 2017 |
| Safe Lifting Consultants Limited | Professional & scientific | 2020 |
| Safe Rescue Ltd | Administrative & support | 2017 |
| Safe Site Services Limited | Administrative & support | 2015 |
| Safe Sleep Normm Limited | Health & social care | 2025 |
| Safe Sterile Solutions Ltd | Administrative & support | 2025 |
| Safe Surface Laser Cleaning Ltd | Administrative & support | 2026 |
| Safe Wood Kitchens Ltd | Construction | 2020 |
| Safecare Alliance Limited | Health & social care | 2022 |
| Safecare Personnel Limited | Health & social care | 2020 |
| Safecare Properties Ltd | Real estate | 2026 |
| Safeguard Fire Limited | Other services | 2018 |
| Safestyle Conservatories Limited | Professional & scientific | 2011 |
| Safestyle Doors Limited | Extraterritorial | 2024 |
| Safestyle Home Improvements Limited | Extraterritorial | 2024 |
| Safestyle Rooftrim Limited | Extraterritorial | 1994 |
| Safestyle Windows Limited | Extraterritorial | 2024 |
| Safety Testing (UK) Limited | Professional & scientific | 2011 |
| Safetyled Solutions Limited | Professional & scientific | 2012 |
| Saffron Estates Ltd. | Construction | 2010 |
| Saffron Housing Finance PLC | Financial services | 2013 |
| Saffy Dixon Ltd | Wholesale & retail | 2022 |
| Safir Yachting Ltd | Manufacturing | 2017 |
| Safs Fast Food Limited | Hospitality | 2020 |
| Sagano Ltd | Professional & scientific | 2019 |
| Sagar Fold Investments Limited | Professional & scientific | 2018 |
| Saggers Consultancy Limited | Real estate | 2025 |
| Sagon UK Ltd | Transport & logistics | 2021 |
| Sahara Arabian Grill and Steakhouse Limited | Hospitality | 2018 |
| Sahara Bar and Restaurant Ltd | Hospitality | 2011 |
| Sahara Cafe and Patisserie Limited | Hospitality | 2018 |
| Sahara Coffee Limited | Hospitality | 2014 |
| SAI Distribution Limited | Transport & logistics | 2009 |
| Saihan Limited | Health & social care | 2021 |
| Saiks Property Ltd | Households | 2025 |
| Sail & Power Boat Training Ltd | Arts & recreation | 2015 |
| Sailaway Ventures Limited | Financial services | 2021 |
| Saima & Grandson Limited | Hospitality | 2017 |
| Saint Andrews Transport Ltd | Transport & logistics | 2023 |
| Saint Benedicts Beauty & Lash Academy Ltd | Wholesale & retail | 2019 |
| Saint Benedicts Properties Limited | Real estate | 2021 |
| Saint George Estates Limited | Real estate | 2021 |
| Saint Vincent Developments Limited | Construction | 1996 |
| Saint Vincent Holdings Limited | Professional & scientific | 2011 |
| Saint Vincent Operations Limited | Real estate | 2002 |
| Saira Sadiq Ltd | Health & social care | 2016 |
| Sait.Edu Ltd | Information & communication | 2017 |
| SAJ Indian Limited | Hospitality | 2019 |
| Sakariya Brothers Limited | Manufacturing | 2025 |
| Sakhi's Company Limited | Health & social care | 2015 |
| Sakunthala Ltd | Wholesale & retail | 2026 |
| Sale Road Gym Limited | Real estate | 1995 |
| Sales & Print Solutions Ltd | Professional & scientific | 2022 |
| Sales Solutions (Norfolk) Ltd | Administrative & support | 2008 |
| Salesupply Office Ltd | Other services | 2020 |
| Salford Foods Ltd | Hospitality | 2020 |
| Salhouse Farm Shop Ltd | Hospitality | 2023 |
| Salhouse Investments Limited | Real estate | 2025 |