| Digital Media UN Limited | Information & communication | 2025 |
| Digital Purpose London Ltd | Information & communication | 2023 |
| Digital Vantage Limited | Professional & scientific | 2023 |
| Dilasser Private Clients Limited | Financial services | 2011 |
| Diligent Properties Ltd | Construction | 2020 |
| DIN Consultants Limited | Information & communication | 1999 |
| DIRECT2CUSTOMER(UK) Limited | Wholesale & retail | 2026 |
| Disability Intelligence Limited | Professional & scientific | 2022 |
| Distributex Limited | Wholesale & retail | 2025 |
| Divine Purehealth Limited | Wholesale & retail | 2013 |
| Dixon Wright Building Consultants Ltd | Professional & scientific | 2015 |
| Djbigtunez Ltd | Arts & recreation | 2010 |
| DK Design and Build Services Ltd | Construction | 2021 |
| DL Property Lettings Ltd | Real estate | 2023 |
| Dmdm Consulting Limited | Information & communication | 2020 |
| DMS Capital Consulting Limited | Administrative & support | 2013 |
| DNB1 Ltd | Construction | 2020 |
| Doberman Pitbull & Rottweiler Limited | Households | 1994 |
| DOC & Mason Ltd | Construction | 2018 |
| Doctor Catalyst Ltd | Professional & scientific | 2010 |
| Dolling Roofing Services Ltd | Construction | 2023 |
| Dost Investments Limited | Real estate | 2023 |
| Dost Properties (Carlton) Limited | Real estate | 2025 |
| Dost Properties (Newark) Limited | Real estate | 2024 |
| DOT PAR Limited | Agriculture & fishing | 2021 |
| DOT Prompt Limited | Information & communication | 2012 |
| DOTS2VALUE Limited | Information & communication | 2023 |
| Double Hundred Properties Ltd | Real estate | 2026 |
| Doublehigh Limited | Financial services | 2024 |
| DP Management Group Ltd | Real estate | 2025 |
| DPK Contractors Limited | Construction | 2001 |
| DR Ahran Arnold Ltd | Health & social care | 2024 |
| DR Investments Ltd | Real estate | 2019 |
| DR Jayantha Arnold Limited | Health & social care | 2014 |
| DR KG Thevan Ltd | Health & social care | 2015 |
| DR Krupa Limited | Health & social care | 2026 |
| DR Muzic Limited | Information & communication | 2021 |
| DR Nichola Conlon Limited | Professional & scientific | 2026 |
| DR Peter Harvey Ltd | Health & social care | 2012 |
| DR Pharma C Ltd | Wholesale & retail | 2025 |
| DR Priyanka Cherian Limited | Health & social care | 2023 |
| DR Simon Jones Ltd | Professional & scientific | 2021 |
| DR Ventures Limited | Hospitality | 2016 |
| Draco Ventures Limited | Financial services | 2018 |
| Draig Fitness Ltd | Manufacturing | 2024 |
| Draw Day Ltd | Arts & recreation | 2026 |
| Dream Nest Builders Ltd | Real estate | 2025 |
| Dreams Cleaning Ltd | Administrative & support | 2025 |
| Dreamsart Cakes Ltd | Manufacturing | 2019 |
| Drivefin Ltd | Financial services | 2026 |
| Drozd Constructor Limited | Construction | 2020 |
| DSL Advisory Partners Ltd | Professional & scientific | 2019 |
| Dudley Management Limited | Real estate | 2018 |
| Dukes Lodge Limited | Households | 1973 |
| Dungeon Innovations Limited | Professional & scientific | 2024 |
| Dunmore Limited | Arts & recreation | 1989 |
| Dunton Wharf Properties Limited | Real estate | 2022 |
| Durga Property Ltd | Real estate | 2020 |
| Dwarkesh UK Limited | Financial services | 2024 |
| Dyma Harkins Limited | Health & social care | 2002 |
| E C C Building Contractors Limited | Construction | 2008 |
| E-Endeavours Limited | Other services | 2007 |
| E-Tech Systems UK Limited | Information & communication | 2003 |
| Eaglefield Holdings Limited | Construction | 2024 |
| Eaglefield Limited | Construction | 2016 |
| Eaglese Ltd. | Financial services | 2013 |
| Ealdown Design Services Limited | Professional & scientific | 2002 |
| Ealing Dental Ltd | Health & social care | 2017 |
| Ealing Dental Specialists Limited | Health & social care | 2006 |
| Earlsfield Energy Infrastructure Limited | Other services | 2024 |
| Earlsmead Properties Limited | Real estate | 2022 |
| Earlswood Wealth Management Ltd | Financial services | 2012 |
| Easilyt Ltd | Wholesale & retail | 2022 |
| Eastbury Avenue (Residents Association) Limited | Households | 1988 |
| Eastbury Farm Consulting Ltd | Professional & scientific | 2012 |
| Eastbury Place (Residents Association) Limited | Real estate | 1979 |
| Eastbury Property Consultancy Services LLP | | 2008 |
| Eastcote Club (Sports) Limited | Real estate | 1980 |
| Easton Enterprises Ltd | Professional & scientific | 2024 |
| Eastwood Management (Northwood) Limited | Real estate | 1995 |
| Eathlos Digital Solutions Limited | Real estate | 2023 |
| ECB Aylesbury Limited | Wholesale & retail | 2021 |
| Eckos Curtains Limited | Manufacturing | 2017 |
| Eco Articles Ltd | Wholesale & retail | 2022 |
| Eco Drains Limited | Administrative & support | 2007 |
| Ecotech Farms Limited | Agriculture & fishing | 2009 |
| Ecrs Property Limited | Real estate | 2016 |
| Ecucheck Ltd | Professional & scientific | 2024 |
| Ediana Consulting Ltd | Professional & scientific | 2015 |
| Edible Creativity | | 1991 |
| Edsolutionservices Ltd | Construction | 2020 |
| Eduaudits Limited | Information & communication | 2019 |
| Edward G Wilcox Investments Ltd | Hospitality | 2019 |
| EGI Property Ltd | Real estate | 2016 |
| Egkim Limited | Professional & scientific | 2022 |
| EGO Venture Capital Limited | Professional & scientific | 2011 |
| Eighty Hair Ltd | Other services | 2007 |
| Ejazah Creations Ltd | Wholesale & retail | 2016 |
| Ejcs Limited | Wholesale & retail | 2019 |
| ELA Consultants Ltd | Health & social care | 2026 |