| Solace Therapy Ltd | Health & social care | 2026 |
| Solanki Management Ltd | Wholesale & retail | 2025 |
| Solar Springs Limited | Wholesale & retail | 2024 |
| Solidbright Limited | Real estate | 2013 |
| SOM Ventures Ltd | Administrative & support | 2025 |
| Sondebase Ltd | Wholesale & retail | 2018 |
| Sophlin Ltd | Professional & scientific | 2015 |
| Sophlin Property Management Ltd | Real estate | 2022 |
| Sorbus Stone Ltd | Professional & scientific | 2026 |
| Sortie DES Ombres Limited | Information & communication | 2017 |
| Sound Hearing Care Limited | Health & social care | 2013 |
| Spacelight 2 Limited | Construction | 2018 |
| Spacelight Ltd | Construction | 2015 |
| SPAREPARTS4COOKERS Limited | Wholesale & retail | 2015 |
| Sparkle & Shine Contract Cleaning Services Limited | Administrative & support | 2025 |
| Sparkling Clean (Cheshire) Ltd | Administrative & support | 2013 |
| Sparklz and Shine Ltd | Administrative & support | 2020 |
| SPD Executive Limited | Professional & scientific | 2004 |
| Speakerly Ltd | Information & communication | 2025 |
| Specialfirm Payroll Services Ltd | Professional & scientific | 2023 |
| Spectranet Systems Limited | Construction | 2011 |
| Spectrometry Vision Limited | Manufacturing | 2005 |
| Spectrum Creations Ltd | Real estate | 2025 |
| Spectrum Legal Ltd | Professional & scientific | 2025 |
| Speedworks Motorsport Limited | Professional & scientific | 2003 |
| Spencer Weston (Investments) Limited | Real estate | 2014 |
| Spencer Weston (Project Management) Limited | Construction | 2014 |
| Spencer Weston Limited | Construction | 2011 |
| Spice Fusion T/A the Indian Ltd | Hospitality | 2022 |
| Spinxperts Ltd | Professional & scientific | 2024 |
| Spondu Limited | Information & communication | 2024 |
| Sportshall Associates Limited | Arts & recreation | 1999 |
| Sportspools Limited | Information & communication | 2021 |
| Spot-On Laser & Tool Company UK Ltd | Manufacturing | 2019 |
| Spotted Dog Gift Company Limited | Wholesale & retail | 2018 |
| Sprint Projects NW Limited | Professional & scientific | 2026 |
| Sprung High Limited | Real estate | 2018 |
| Spuds UP Ltd | Hospitality | 2024 |
| Squirrel - Vault Ltd | Construction | 2024 |
| Sree Health Care Limited | Health & social care | 2020 |
| Sreshta Associates Ltd | Information & communication | 2015 |
| Srghospitality Ltd | Hospitality | 2024 |
| SRL Bakery Ltd | Manufacturing | 2026 |
| SRS Stores Ltd | Wholesale & retail | 2024 |
| SS Station Road Stores Ltd | Wholesale & retail | 2019 |
| SSG Advisory Ltd | Professional & scientific | 2011 |
| SSL (Wharf) Limited | Hospitality | 2020 |
| SSL Group Holdings Limited | Financial services | 2024 |
| ST Courier and Transport Ltd | Transport & logistics | 2019 |
| ST Marks Services Ltd | Manufacturing | 2024 |
| Stables Management (Whatcroft 1993) Limited | Real estate | 1993 |
| Stairshape Limited | Construction | 2024 |
| Stait Sounds Ltd | Information & communication | 2025 |
| Stannseal Limited | Real estate | 2006 |
| Stanrose Properties Limited | Real estate | 2018 |
| Star and Carter Limited | Wholesale & retail | 2018 |
| Star Food 1 Ltd | Hospitality | 2026 |
| Stark Brooks Associates Limited | Administrative & support | 1983 |
| Stark Brooks Group Limited | Professional & scientific | 2001 |
| Stark Export Focus Limited | Administrative & support | 2006 |
| Stars Work Ltd | Construction | 2013 |
| Station Road Garage (Northwich) Limited | Wholesale & retail | 2013 |
| Steady House Ltd | Information & communication | 2026 |
| Stealth Security UK Limited | Administrative & support | 2002 |
| Steel Viking Ltd | Arts & recreation | 2020 |
| Steer Management Services Limited | Real estate | 2000 |
| Steer Property Services Limited | Real estate | 2004 |
| Stefan Kordecki Building Solutions Ltd | Real estate | 2017 |
| Stefos Barrett Inc Ltd | Professional & scientific | 2024 |
| Stelfox Consulting Ltd | Professional & scientific | 2025 |
| Stellar Holdings Limited | Information & communication | 2015 |
| Stellar Holdings Worldwide Limited | Transport & logistics | 1999 |
| STEP2PROTECT Ltd | Financial services | 2015 |
| Stephen Anthony Ltd | Information & communication | 2013 |
| Stephen Goodman Consulting Limited | Professional & scientific | 2004 |
| Steve Conway Consulting Ltd | Professional & scientific | 2025 |
| Steve Taylor Barnton Building Limited | Construction | 2014 |
| Stmc (Building Control) Limited | Professional & scientific | 1997 |
| Stmc Holdings Limited | Financial services | 2020 |
| Stockwell Safety Limited | Professional & scientific | 2022 |
| Stone Business Consultancy Limited | Professional & scientific | 2022 |
| Stonehewer Moss Limited | Professional & scientific | 2005 |
| Stones Group Limited | Professional & scientific | 2018 |
| Stop Pause Think NOW ACT Ltd | Professional & scientific | 2020 |
| Stop Pause Think NOW ACT Wellbeing Ltd | Professional & scientific | 2025 |
| Storage Station Limited | Transport & logistics | 2024 |
| Storengy UK Limited | Energy | 2007 |
| Storey Cheshire Ltd | Real estate | 2018 |
| Storeys Holdings Ltd | Financial services | 2022 |
| Storm in the Community CIC | Other services | 2025 |
| Storm Sealed Roofline Ltd | Construction | 2016 |
| Storychest Limited | Information & communication | 2014 |
| Stotts Gardening Ltd | Administrative & support | 2014 |
| Stove Expert Limited | Construction | 2014 |
| STR Procurement Ltd | Professional & scientific | 2025 |
| Straits Limited | Professional & scientific | 2020 |
| Strata Recoup Ltd | Administrative & support | 2026 |
| Strawberry Recording Studios Ltd | Information & communication | 2018 |
| Strictly Mobile Bars Limited | Hospitality | 2014 |
| Strike Fencing Contractors Ltd | Construction | 2010 |