| DPG Design Ltd | Professional & scientific | 2015 |
| DPM Commercial Limited | Real estate | 2024 |
| DPM Housing Limited | Real estate | 2017 |
| DR Jessamy Ltd | Information & communication | 2018 |
| DR Joe's Premium Pet Food Ltd | Manufacturing | 2024 |
| DR Sarah Davies Limited | Health & social care | 2020 |
| DR. Eric Holroyd Cardiologist Limited | Health & social care | 2018 |
| Dreambox Publishing Limited | Information & communication | 2017 |
| Dreamscape Solutions Limited | Information & communication | 2006 |
| Dreamstar Travel & Events Ltd | Administrative & support | 2018 |
| Dricklehome Ltd | | 2008 |
| Driftwood Rentals Ltd | Administrative & support | 2025 |
| Drive Manchester Ltd | Education | 2019 |
| DRL Foods Ltd | Hospitality | 2026 |
| Drone Vision UK Ltd | Professional & scientific | 2021 |
| DRY Basements Ltd | Construction | 2018 |
| DS Creative Strategy Ltd | Professional & scientific | 2026 |
| DSC Real Estate Ltd | Real estate | 2025 |
| DSG Auto Ltd | Wholesale & retail | 2025 |
| DSN Cymru Limited | Health & social care | 2009 |
| DSN Retail Limited | Wholesale & retail | 2014 |
| DU Services Limited | Administrative & support | 2016 |
| Duality With Jess Limited | Health & social care | 2023 |
| Duda Coffee Limited | Manufacturing | 2024 |
| Duffco Limited | Financial services | 2017 |
| Dugdale Prestige Automotive Ltd | Wholesale & retail | 2024 |
| Dugdale Prestige Mechanical Limited | Wholesale & retail | 2025 |
| Dunne Removal Services Ltd | Transport & logistics | 2026 |
| Duplet Games Ltd | Information & communication | 2022 |
| Dutton Locks Leisure Limited | Real estate | 2018 |
| Duxx Limited | Administrative & support | 1998 |
| DVE Holdings Limited | Real estate | 2021 |
| DW Coach Consult Limited | Professional & scientific | 2015 |
| DW Gardening Maintenance Ltd. | Administrative & support | 2003 |
| DX Digital Ltd | Information & communication | 2007 |
| Dylan Construction Ltd | Construction | 2019 |
| Dynamic Building Solutions Ltd | Construction | 2011 |
| E & M Consulting Services Ltd | Professional & scientific | 2019 |
| E and G Group Limited | Education | 2023 |
| E Martin Property Limited | Real estate | 2022 |
| E&L78 Ltd | Construction | 2020 |
| E@D Decoration Ltd | Construction | 2023 |
| Eaca Commercial Ltd | Professional & scientific | 2025 |
| Each Their Own Ltd | Wholesale & retail | 2026 |
| Eagle Rock Investments Ltd | Real estate | 2014 |
| EAN Electrical Ltd | Construction | 2017 |
| Earl of Mercia Ltd | Hospitality | 2026 |
| Early Dart Ltd | Professional & scientific | 2024 |
| Early Dart Property Ltd | Construction | 2024 |
| East Cheshire Accountants Ltd | Professional & scientific | 2021 |
| Eatonwell Limited | Extraterritorial | 2007 |
| EC0-OPTION Management Ltd | Professional & scientific | 1999 |
| Echovia Developments Ltd | Construction | 2016 |
| Eclectic Financial Solutions Limited | Real estate | 2008 |
| Eco Renewables Group Limited | Construction | 2016 |
| Eco-Option (UK) Limited | Water & waste | 1994 |
| Ecogreen Equestrian Limited | Other services | 2014 |
| Ecolab Limited | Manufacturing | 1960 |
| Ecolab Manufacturing UK Limited | Administrative & support | 1998 |
| Ecological Energy Solutions Ltd | Construction | 2009 |
| ED 23 Ltd | Construction | 2023 |
| Edam Enterprise Ltd | Real estate | 2020 |
| Eddisbury Property Company Limited | Real estate | 1895 |
| Eddy Langley Coaching Limited | Education | 2022 |
| Edelchemie LP | | 2010 |
| Eden Mora Ltd | Administrative & support | 2024 |
| Edge Sci-Tech Limited | Professional & scientific | 2025 |
| Edge Technical Services Limited | Information & communication | 2008 |
| Edge View Ltd | Professional & scientific | 2024 |
| Ednet Limited | Administrative & support | 2022 |
| Edward Boler Ventures Limited | Financial services | 2024 |
| Edward Henry Investments Limited | Real estate | 2016 |
| Edward Street Garage Limited | Wholesale & retail | 2003 |
| Edwards Property Portfolio Limited | Real estate | 2017 |
| EFE 2 Ltd | Hospitality | 2025 |
| EFE Kebab 1 Ltd | Hospitality | 2025 |
| Egsl Limited | Health & social care | 2016 |
| EHI Support Ltd | Professional & scientific | 2008 |
| Eiandsonsproperty Ltd | Real estate | 2026 |
| EJB Estates Limited | Real estate | 2016 |
| EJM Management Limited | Administrative & support | 2026 |
| EL - Property Group Ltd | Real estate | 2020 |
| El-Roi First Consulting Ltd | Information & communication | 2026 |
| Elara Group Commercial Limited | Administrative & support | 2008 |
| Electric Chek Ltd | Construction | 2006 |
| Electrical Development Solutions Ltd | Construction | 2026 |
| Electricmotocycles Ltd | Wholesale & retail | 2019 |
| Elekgo Ltd | Wholesale & retail | 2025 |
| Element Games Ltd | Wholesale & retail | 2014 |
| Element Games Retail Ltd | Wholesale & retail | 2023 |
| Elevanta Workforce Ltd | Administrative & support | 2026 |
| Elevate Aviation Services Limited | Transport & logistics | 2021 |
| Elevated Building Solutions Ltd | Construction | 2024 |
| Eleven Management Group Ltd | Financial services | 2026 |
| Elimar Pigeon Services Limited | Other services | 2018 |
| Elite Automotive Group Ltd | Wholesale & retail | 2024 |
| Elite Health and Performance Ltd | Health & social care | 2020 |
| Elite Lettings Cheshire Ltd | Households | 2025 |
| Elliott & Co Accountancy Limited | Professional & scientific | 2013 |
| Elliott & Heyes Installations Ltd | Construction | 2022 |