| Deans of Northwich Limited | Transport & logistics | 2000 |
| Deansland Communications Limited | Professional & scientific | 2009 |
| Decent Doings Limited | Professional & scientific | 2025 |
| Dechra Finance Australia Limited | Financial services | 2016 |
| Dechra Finance Limited | Financial services | 2014 |
| Dechra Finance Sterling Limited | Financial services | 2016 |
| Dechra Group Holdings Limited | Financial services | 2023 |
| Dechra Investments Limited | Financial services | 2004 |
| Dechra Midco Limited | Financial services | 2023 |
| Dechra Pharmaceuticals Holdings Limited | Financial services | 2023 |
| Dechra Pharmaceuticals Limited | Professional & scientific | 1997 |
| Dechra Topco Limited | Financial services | 2023 |
| Dechra Veterinary Products Limited | Wholesale & retail | 2005 |
| Deckinate Ltd | Arts & recreation | 2023 |
| Dee's Autos Limited | Wholesale & retail | 2023 |
| Deeply Vale (Deepley Vale) Festival Original Organisers and Concept Limited | Information & communication | 1999 |
| Defacto Fieldwork Insights Limited | Professional & scientific | 2024 |
| Define Consultancy Services Ltd | Administrative & support | 2025 |
| Define Food and Wine Limited | Wholesale & retail | 2000 |
| Define Performance Ltd | Professional & scientific | 2015 |
| Degirmen Ltd | Information & communication | 2010 |
| Delamere Builders Ltd | Other services | 2019 |
| Delamere Health Prop Co 1 Limited | Real estate | 2022 |
| Delamere Manor (Events) Limited | Hospitality | 2014 |
| Delamere Park Management Limited | Households | 1971 |
| Delamere Pods Ltd | Other services | 2019 |
| Delfina Marketing Limited | Administrative & support | 2002 |
| DELIVERY2DAY Limited | Hospitality | 2026 |
| Delphinium Group Ltd | Financial services | 2024 |
| Delphinium Property Ltd | Real estate | 2023 |
| Delve Recruitment Limited | Administrative & support | 2017 |
| Dema Clean Solutions Ltd | Administrative & support | 2025 |
| Dema Solutions Limited | Administrative & support | 2017 |
| Demo Clean Ltd | Real estate | 2018 |
| Denefex Ltd | Wholesale & retail | 2026 |
| Dennison & Lawrence Limited | Other services | 1966 |
| Design 79 Solutions Limited | Professional & scientific | 2008 |
| Design Dedication & Innovation Developments Limited | Construction | 1996 |
| Design Makes Project Ltd | Professional & scientific | 2020 |
| Design Print Create Ltd | Manufacturing | 2019 |
| Design Services North West Ltd | Professional & scientific | 2018 |
| Designed Network Solutions Limited | Professional & scientific | 2015 |
| Development First Coaching Ltd | Education | 2021 |
| Devux Technology Limited | Information & communication | 2023 |
| DEX Centum Ltd | Information & communication | 2024 |
| DEY Consultancy Services Ltd | Real estate | 2006 |
| DG ALL Seasons Limited | Real estate | 2023 |
| DHH (Property Management) Limited | Real estate | 2017 |
| Diadem Structural Consultants Ltd | Professional & scientific | 2015 |
| Dial Axis Ltd | Construction | 2026 |
| Diamond Nails (Cheshire) Ltd | Other services | 2015 |
| DIG Rewards Limited | Information & communication | 2022 |
| Digital Race Electronics Limited | Wholesale & retail | 2001 |
| Diilara Home Delivery & Mobile Grill Bar Ltd | Hospitality | 2025 |
| Dimension Building Consultancy Ltd | Professional & scientific | 2024 |
| Direct 1ST Limited | Other services | 2022 |
| Direct Bottled GAS Ltd | Administrative & support | 2021 |
| Direct Carpets (Cheshire) Limited | Wholesale & retail | 2018 |
| Direla Services Limited | Administrative & support | 2013 |
| Disability Positive | Public administration | 2000 |
| Discovery Events Limited | Administrative & support | 2007 |
| Disrupt and Thrive Limited | Information & communication | 2018 |
| Divergent Thinkers Limited | Administrative & support | 2024 |
| Division Design Limited | Professional & scientific | 2007 |
| Djlewis Engineering Ltd | Professional & scientific | 2019 |
| Djurdjura Ltd | Hospitality | 2026 |
| DJW Lodge Enterprises Ltd | Real estate | 2015 |
| DMJ Leisure Ltd | Other services | 2013 |
| DMK Trans Limited | Transport & logistics | 2016 |
| DMT Solutions Limited | Extraterritorial | 2011 |
| Dnote Limited | Information & communication | 2023 |
| DNS Environmental Limited | Professional & scientific | 2024 |
| DNS Software Ltd | Information & communication | 2024 |
| Dobsonandbarton Limited | Arts & recreation | 2024 |
| Docan Ltd | Professional & scientific | 2015 |
| Dodgson & Bell Funeral Services Limited | Other services | 1984 |
| Doherty Design Limited | Professional & scientific | 2025 |
| Dolly’S Dinky Doggy Daycare Ltd | Other services | 2024 |
| Domi Build Ltd | Construction | 2025 |
| Domi Lettings Ltd | Real estate | 2025 |
| Domi Ventures Ltd | Real estate | 2018 |
| Domocond Limited | Real estate | 2025 |
| Domokern Limited | Real estate | 2025 |
| Domokreo Limited | Construction | 2025 |
| Domoluo Limited | Real estate | 2017 |
| DON Houghton Builders Limited | Construction | 2000 |
| Doncaster Regenco Limited | Real estate | 2018 |
| Donkey Properties Ltd | Real estate | 2025 |
| Donna Davies Training Ltd | Education | 2021 |
| Doodlebox Music Limited | Information & communication | 2017 |
| Doozie Ltd | Manufacturing | 2022 |
| Dormouse Haven Limited | Hospitality | 2024 |
| Dotcomideas.Co.Uk Limited | Professional & scientific | 2000 |
| Dottie Lettings Ltd | Real estate | 2024 |
| Double AA Surgicals Ltd | Health & social care | 2012 |
| Doublestripe Limited | Information & communication | 2016 |
| Douglas MON Limited | Hospitality | 2014 |
| Doyashi Engineering Limited | Professional & scientific | 2018 |
| DP Chance Ltd | Information & communication | 2023 |
| DP Joinery Limited | Construction | 2012 |