| Derazia Limited | Wholesale & retail | 2020 |
| Derbyshire Holdings Limited | Financial services | 2015 |
| Derico Healthcare Ltd | Health & social care | 2024 |
| Derma Faces Ltd | Other services | 2024 |
| Derngate Property Group Ltd | Real estate | 2026 |
| Derngate Property Ltd | Real estate | 2025 |
| Derngate Social Ltd | Hospitality | 2022 |
| Derngate Wealth Management Limited | Extraterritorial | 2016 |
| Derryscroft Ltd | Real estate | 2013 |
| Derut Construct Limited | Construction | 2018 |
| Desi Depot Ltd | Wholesale & retail | 2023 |
| Desi Wardrobe Ltd | Wholesale & retail | 2025 |
| Design and Deliver Marketing Limited | Information & communication | 2006 |
| Design Beyond Ltd | Professional & scientific | 2026 |
| Design Business Wholesale Ltd | Wholesale & retail | 2025 |
| Design Intelligence & Mechanical Engineering Ltd | Professional & scientific | 2015 |
| Design Style Interiors Ltd | Professional & scientific | 2025 |
| Design Web Consultancy Limited | Information & communication | 2009 |
| Designed by US Ltd | Information & communication | 2012 |
| Designed in Wood Ltd | Extraterritorial | 2024 |
| Designer Golf Limited | Extraterritorial | 1998 |
| Designer Trading Ltd | Wholesale & retail | 2018 |
| Designhaus Shropshire Limited | Construction | 2019 |
| Designstore of Fulham Road Limited | Professional & scientific | 1988 |
| Desilu Estates Limited | Real estate | 1988 |
| Desired Lengths Ltd | Other services | 2018 |
| Desistyle Ltd | Wholesale & retail | 2025 |
| Deskbuzz Limited | Wholesale & retail | 2018 |
| Desninghall Farms Limited | Agriculture & fishing | 2018 |
| Destination Kemet Limited | Administrative & support | 2023 |
| Destination Lincolnshire Community Interest Company | Other services | 2018 |
| Destiny Connect Solutions Ltd | Administrative & support | 2017 |
| Devbs Homes Ltd | Real estate | 2025 |
| Devbudz Ltd | Wholesale & retail | 2024 |
| Devcrux Technologies Limited | Information & communication | 2023 |
| Development AID From People to People UK | Wholesale & retail | 2006 |
| Development Capital Group Limited | Construction | 2019 |
| Develux Ltd | Construction | 2021 |
| Devereux Homes Limited | Real estate | 2017 |
| Deves Fuel Ltd | Wholesale & retail | 2022 |
| Devie Construction Limited | Professional & scientific | 2016 |
| Devin Furniture Ltd | Manufacturing | 2022 |
| Devine Jewellery Ltd | Wholesale & retail | 2026 |
| Devinedetails Ltd | Manufacturing | 2017 |
| Devolliu Ltd | Hospitality | 2019 |
| Devon & Somerset Inns Limited | Hospitality | 1990 |
| DEX Elite Ltd | Education | 2017 |
| DEX Events Limited | Arts & recreation | 2018 |
| Dexter AI Limited | Information & communication | 2023 |
| Dexter Driving Ltd | Education | 2018 |
| Dexterity RGC Limited | Arts & recreation | 2017 |
| Dexterous With Numbers Limited | Professional & scientific | 2023 |
| DF Contractors Limited | Construction | 2011 |
| Df.Landscaping Limited | Professional & scientific | 2025 |
| Dfam Limited | Wholesale & retail | 2016 |
| DFH 1 Limited | Real estate | 2022 |
| DFK Community Wellbeing Hub for Music & Art CIC | Education | 2025 |
| DFL Security Ltd | Administrative & support | 2021 |
| DFL Services Ltd | Transport & logistics | 2016 |
| DFM7 Limited | Financial services | 2023 |
| DFP Bespoke Stone Ltd | Manufacturing | 2018 |
| DFS Transport Ltd | Transport & logistics | 2025 |
| DFT Property Management Limited | Real estate | 2011 |
| DFX Software Ltd | Information & communication | 2024 |
| Dfyj Ltd | Hospitality | 2025 |
| DG Ceilings & Partitions Ltd | Construction | 2026 |
| DG Taylor's Ltd | Hospitality | 2018 |
| DGB Construct Ltd | Construction | 2022 |
| DGL Construction Ltd | Construction | 2018 |
| DGL Engineering Ltd | Manufacturing | 2025 |
| DGS Contracting Ltd | Construction | 2023 |
| Dgth Music Ltd | Information & communication | 2024 |
| DGX International Ltd | Manufacturing | 2026 |
| DH & Sons Ltd | Administrative & support | 2022 |
| DH Building Ltd | Construction | 2006 |
| DH Valeting Ltd | Other services | 2020 |
| DHA IT Solutions Ltd | Information & communication | 2024 |
| DHC Services Limited | Construction | 2016 |
| Dhwani Arya Limited | Hospitality | 2023 |
| Di/Vo Consulting Limited | Information & communication | 2021 |
| DIA Sweets Ltd | Manufacturing | 2022 |
| Diabar Ltd | Wholesale & retail | 2011 |
| Diabelist Ltd | Information & communication | 2026 |
| Diagfix Ltd | Wholesale & retail | 2023 |
| Diagrams Limited | Extraterritorial | 1997 |
| Dial - a - Carpet (Northampton) Limited | Extraterritorial | 1997 |
| Dial a Dog Wash Northampton Ltd | Other services | 2024 |
| Dial IT Hub Ltd | Information & communication | 2024 |
| Dialect Telecom Limited | Information & communication | 2007 |
| Diamanti & Amore Property Services Limited | Households | 2019 |
| Diamond Appearance Limited | Other services | 2020 |
| Diamond Car Wash Northampton Ltd | Other services | 2017 |
| Diamond Construction & Building Services Ltd | Construction | 2018 |
| Diamond Dental Therapy Limited | Health & social care | 2017 |
| Diamond Design and Development Ltd | Information & communication | 2020 |
| Diamond Displays Ltd | Wholesale & retail | 2023 |
| Diamond Estates (Northampton) Ltd | Real estate | 2017 |
| Diamond Installations & Refurbishments Limited | Construction | 2024 |
| Diamond K9 Solutions Ltd | Administrative & support | 2020 |
| Diamond Landmark Limited | Financial services | 2025 |