| Eber Actuarial Ltd | Financial services | 2022 |
| EBIKES4WORK Limited | Transport & logistics | 2024 |
| Eclipse Prom Store Ltd | Wholesale & retail | 2024 |
| ECR Property Ltd | Real estate | 2024 |
| ECS Textiles Limited | Wholesale & retail | 2014 |
| Eden Farm Limited | Hospitality | 1964 |
| EDR 3 Ltd | Professional & scientific | 2019 |
| Edst Ltd | Information & communication | 2005 |
| EDU-C8 Inspired Training Ltd | Education | 2017 |
| Edunite International Limited | Education | 2023 |
| Edwards Architecture Limited | Professional & scientific | 2011 |
| Effective Coatings Limited | Construction | 2025 |
| Eggr Limited | Wholesale & retail | 2023 |
| EH Driver & Maintenance Ltd | Transport & logistics | 2026 |
| EIS ALB Ltd | Hospitality | 2025 |
| Ej&B Limited | Construction | 2023 |
| Elara Community & Events Ltd | Information & communication | 2025 |
| Eldon Heating Limited | Construction | 1979 |
| Eleanor Allen Property Limited | Real estate | 2024 |
| Elecsys Technologies Limited | Information & communication | 2021 |
| Electric Heating Systems Ltd | Manufacturing | 2021 |
| Electric Storage Systems Ltd | Wholesale & retail | 2015 |
| Electrical & Property Maintenance Ltd | Construction | 2024 |
| Electricalaf Ltd | Construction | 2025 |
| Electricco Ltd | Manufacturing | 2019 |
| Electrotype Ltd | Manufacturing | 2010 |
| Elegant Resin Ltd | Construction | 2025 |
| Element 3 Electrical Limited | Construction | 2019 |
| Element 3 North East Limited | Construction | 2013 |
| Elements Arts Limited | Education | 2025 |
| ELEV8 Fitness Training Ltd | Health & social care | 2025 |
| Elevate Culture Ltd | Information & communication | 2025 |
| Eleven SIX Zero Ltd | Information & communication | 2022 |
| Elite Closing Ltd | Wholesale & retail | 2025 |
| Elite Construct Ltd | Construction | 2025 |
| Elless Promotion Limited | Administrative & support | 2014 |
| Elliot Wright Ltd | Hospitality | 2023 |
| Elliott-Collinson Limited | Hospitality | 2021 |
| ELT Media Ltd | Other services | 2022 |
| Eltringham Syndicate Fishing Limited | Agriculture & fishing | 2007 |
| Elucidar Ltd | Administrative & support | 2017 |
| Emco Door Limited | Wholesale & retail | 2014 |
| Emerchantpay Group Consolidated Holdings Limited | Financial services | 2024 |
| Emerchantpay Group Limited | Financial services | 2018 |
| Emerchantpay International Limited | Information & communication | 2001 |
| Emerchantpay Limited | Financial services | 2004 |
| Emerchantpay UK Services Ltd | Professional & scientific | 2010 |
| Emerchantpay.Com Limited | Professional & scientific | 2008 |
| Emily Downes Ltd | Professional & scientific | 2022 |
| Emily Jayne Signature Beauty Ltd | Other services | 2020 |
| Emma Hedley Ltd | Manufacturing | 2019 |
| Emmry (UK) Limited | Professional & scientific | 2018 |
| Empbill Ltd | Professional & scientific | 2011 |
| Emppay Limited | Other services | 2007 |
| Emroo Ltd | Wholesale & retail | 2020 |
| EMS Management Holdings Limited | Financial services | 2025 |
| Enational Holdings Limited | Professional & scientific | 2016 |
| Encompass 24 Ltd | Health & social care | 2023 |
| Endiprev UK Limited | Administrative & support | 2022 |
| Energy Grant Finder Ltd | Professional & scientific | 2024 |
| Energy Made Simple Limited | Other services | 2016 |
| Energytech Electrical Services Limited | Construction | 2019 |
| ENG Smart Ltd | Manufacturing | 2018 |
| Engage Asset Capital Ltd | Extraterritorial | 2024 |
| Engage Coaching & Consultancy Ltd | Other services | 2010 |
| Engineering Components and Services Ltd | Professional & scientific | 2017 |
| Engineering Services Consultants Limited | Professional & scientific | 2024 |
| Engineers Academy Ltd | Education | 2017 |
| Enigma TAP Ltd | Hospitality | 2018 |
| Enigma Wills & Trusts Limited | Professional & scientific | 2008 |
| Enriched Life Limited | Information & communication | 2021 |
| Enright Estates Ltd | Real estate | 2024 |
| Enright Projects Ltd | Professional & scientific | 2012 |
| Enright Richards Ltd | Real estate | 2019 |
| Entanglement Law and Finance Consulting Ltd | Real estate | 2024 |
| Environmental Measurements Limited | Manufacturing | 1980 |
| Envirosafe Chartered Consultants Limited | Professional & scientific | 2003 |
| ENY Enterprise Ltd | Wholesale & retail | 2024 |
| Ephemere Ltd | Information & communication | 2015 |
| Epicurus Catering Limited | Hospitality | 2024 |
| EQ Office Limited | Wholesale & retail | 2021 |
| Eson Direct UK Limited | Wholesale & retail | 2019 |
| Essell Accountants Limited | Professional & scientific | 2014 |
| Ethical Planning (North East) Limited | Professional & scientific | 2019 |
| ETM FBA Ltd | Wholesale & retail | 2023 |
| Ettie a Holland Ltd | Arts & recreation | 2018 |
| Evak Developments Limited | Construction | 2025 |
| Evak Holdings Ltd | Real estate | 2025 |
| Evaluation Expertise Limited | Professional & scientific | 2013 |
| Evans & Associates Property Acquisitions Ltd | Real estate | 2014 |
| Everyday Care & Support Ltd | Health & social care | 2011 |
| Everyday Homes Ltd | Extraterritorial | 2019 |
| Evoke Bespoke Ltd | Other services | 2022 |
| Ewan Bramley Dental Care Ltd | Health & social care | 2012 |
| Excellence Consultancy Limited | Professional & scientific | 2013 |
| Exchange 1856 Propco Limited | Real estate | 2024 |
| Exchange Point North Tyneside Limited | Manufacturing | 2025 |
| Exclusive Housekeeping Ltd | Administrative & support | 2017 |
| Executive Project Managers Limited | Information & communication | 2023 |
| Expanded Creative Coherence (EC2) Ltd | Other services | 2019 |