| Expected Value Limited | Wholesale & retail | 2020 |
| Expert Tiling Solutions Limited | Construction | 2014 |
| Extraordinary Consultancy Limited | Professional & scientific | 2011 |
| EYE of the Tyne Photography Ltd | Professional & scientific | 2019 |
| Ezeecard Ltd | Financial services | 2013 |
| Ezekiel Properties Limited | Real estate | 2020 |
| F.A.M. Soft Drinks Limited | Financial services | 2016 |
| F.H. (Residential Management) Limited | Households | 1987 |
| F.W. Bishop & SON Limited | Wholesale & retail | 1963 |
| F520 TYM Ltd | Other services | 2026 |
| Fabian Next Global Ltd | Manufacturing | 2026 |
| Fairfield Earthworks Engineering Services Ltd | Construction | 2023 |
| Fai’S North Shields Limited | Hospitality | 2024 |
| Falconer (Cullercoats) Management Company Limited | Households | 2020 |
| Fancy Goods UK Ltd | Wholesale & retail | 2021 |
| Farsi Foods Limited | Manufacturing | 1991 |
| Fast Lane Roadmarkings (North East) Ltd | Construction | 2018 |
| FAT OX Food Ltd | Hospitality | 2024 |
| FAT OX Golf Ltd | Hospitality | 2024 |
| FAT32 Ltd | Information & communication | 2023 |
| FCB Properties Limited | Real estate | 2017 |
| FCX Consulting Ltd | Information & communication | 2025 |
| Feel at Home Development Limited | Hospitality | 2017 |
| Fellows Holding Group Ltd | Information & communication | 2019 |
| Fern Wellness Ltd | Other services | 2021 |
| Ffreckle Ltd | Wholesale & retail | 2025 |
| Fida Systems Ltd | Administrative & support | 2007 |
| Fifty Five (Newcastle) Limited | Hospitality | 2014 |
| Fifty Five Digital Limited | Information & communication | 2014 |
| Filla Ltd | Manufacturing | 2026 |
| Financial Services Corporation Limited | Financial services | 2017 |
| Fine Fettle Home Ltd | Wholesale & retail | 2014 |
| Firefly: Fire Safety Consultancy Ltd | Professional & scientific | 2015 |
| First Come First Served North East Ltd | Wholesale & retail | 2024 |
| First Financial Services Ltd | Financial services | 2022 |
| Fishing Management (NE) Limited | Agriculture & fishing | 2007 |
| Fishnet Tavern Ltd | Hospitality | 2024 |
| Flame Screen Ltd | Professional & scientific | 2009 |
| Flash House Brewing Company Limited | Manufacturing | 2015 |
| Flawless Moments Beauty and Aesthetics Limited | Other services | 2022 |
| Flawless Moments Education Limited | Other services | 2022 |
| Flexademy Ltd | Education | 2025 |
| Flipside Media Ltd | Professional & scientific | 2026 |
| Floc Studio Ltd | Professional & scientific | 2023 |
| Floent Ltd | Information & communication | 2026 |
| Floor Shack Ltd | Wholesale & retail | 2024 |
| Flows With FI Ltd | Arts & recreation | 2025 |
| Fluxsonic Ltd | Professional & scientific | 2018 |
| Food Tech Solutions Limited | Professional & scientific | 2004 |
| Foons Collectables Limited | Wholesale & retail | 2026 |
| Footnotes & Tangents Ltd | Arts & recreation | 2025 |
| FORCE55 Ltd | Professional & scientific | 2012 |
| Fort Knox Property Protection Ltd | Administrative & support | 2020 |
| Fortunate Care Ltd | Health & social care | 2021 |
| Fourteen Motor Company Ltd | Wholesale & retail | 2023 |
| Foxhunters Tyres & Alloys Limited | Wholesale & retail | 1998 |
| Foxtrot Oscar NE Ltd | Wholesale & retail | 2020 |
| FPN Health Limited | Health & social care | 2019 |
| Frango Energy Ltd | Professional & scientific | 2025 |
| Frank Brands International Ltd | Professional & scientific | 2024 |
| Frank Round Limited | Wholesale & retail | 1979 |
| Fred Wellbeing Ltd | Administrative & support | 2023 |
| Freebird Studio Ltd | Other services | 2019 |
| French's Commercial Cleaning Limited | Administrative & support | 2020 |
| Freudenberg Technical Products LP | | 1989 |
| Freudenberg Technical Products Pension Trust Company Limited | Other services | 1989 |
| Freya Lifestyle Limited | Other services | 2024 |
| Friends of Tynemouth Outdoor Pool | Arts & recreation | 2012 |
| FRO YO Newcastle Limited | Hospitality | 2026 |
| Frogzlegz Limited | Education | 2013 |
| Front ST. Ltd. | Hospitality | 2018 |
| Front Street Ltd | Real estate | 2014 |
| FT Fitness Ltd | Arts & recreation | 2023 |
| FT Property Services Limited | Construction | 2018 |
| Fueld NE Ltd | Hospitality | 2025 |
| Fulcrum Mechanical Services Ltd | Wholesale & retail | 2023 |
| Fulinmen Limited | Hospitality | 2018 |
| Full Circle Consulting NE Limited | Professional & scientific | 2025 |
| Fundraising Everywhere Ltd | Information & communication | 2020 |
| Funis Ltd | Construction | 2025 |
| Furnish Property Staging Ltd | Professional & scientific | 2024 |
| Furniture Assembly Services Ltd | Construction | 2011 |
| Future Farming North East Ltd | Manufacturing | 2019 |
| Future Funding Ltd | Real estate | 2005 |
| Futured NE Ltd | Other services | 2023 |
| Fuzzy Logic Studio Ltd | Information & communication | 2020 |
| Fwhousing Ltd | Extraterritorial | 2025 |
| G a Joiners & Builders Limited | Construction | 2006 |
| G D LEE Building Services Limited | Construction | 2005 |
| G E O Fabrication Services Ltd | Manufacturing | 2013 |
| G K Kitchens Ltd | Construction | 2013 |
| G W T Decorators Limited | Construction | 2021 |
| GA Consultancies Limited | Administrative & support | 2015 |
| Gabrielle Louise Ltd | Other services | 2020 |
| Galashiels Mobility Limited | Wholesale & retail | 2019 |
| Gameface Media Limited | Professional & scientific | 2026 |
| Garago Limited | Information & communication | 2021 |
| Gary Senior Consulting Ltd | Professional & scientific | 2022 |
| Gary Watson (Mo-Tech) Limited | Wholesale & retail | 2002 |
| Gazabela Investments Ltd | Real estate | 2017 |