| Robertson Life Limited | Professional & scientific | 2022 |
| Robertson North Ltd | Professional & scientific | 2014 |
| Robsan Accountancy Services Limited | Professional & scientific | 2025 |
| Robson Collective Limited | Professional & scientific | 2020 |
| ROE Holdings Limited | Real estate | 2018 |
| Rokins Properties Limited | Construction | 2014 |
| Rooftops North East Limited | Construction | 2010 |
| Rose-Smith Digital Limited | Professional & scientific | 2024 |
| Rosetim Ltd | Health & social care | 2022 |
| Rosewood Data Ltd | Administrative & support | 2025 |
| Rosina Limited | Hospitality | 2024 |
| Ross & Co Accounting Ltd | Professional & scientific | 2025 |
| Ross Rigging Ltd | Professional & scientific | 2026 |
| Rosserk Park Properties Limited | Real estate | 2013 |
| Rothbury Investments Limited | Real estate | 2004 |
| Rothbury Terrace Properties Limited | Real estate | 2004 |
| Rouven Snowdon Financial Services Limited | Financial services | 2019 |
| Rowstor Leisure Ltd | Hospitality | 2023 |
| RP Contractors Ltd | Construction | 2014 |
| Rplace Holdings Ltd | Financial services | 2025 |
| RPS Commercial Holdings Limited | Real estate | 2020 |
| RS Classic & Performance Ltd | Wholesale & retail | 2017 |
| RS Ember Properties Limited | Real estate | 2015 |
| RS Performance (NE) Ltd | Wholesale & retail | 2025 |
| RSR Hospitality TM Ltd | Hospitality | 2026 |
| Rsvc Ltd | Administrative & support | 2024 |
| RTL Dynamics Ltd | Construction | 2025 |
| RTS Wind Group Ltd | Construction | 2016 |
| RTW Training Services Limited | Education | 2009 |
| Rub-A-Dub Cleaning Ltd | Administrative & support | 2008 |
| Rubber Duck Cars Ltd | Wholesale & retail | 2020 |
| Rubylemon Limited | Administrative & support | 2019 |
| Ruivo Monkey Ltd | Wholesale & retail | 2014 |
| Run Free Food Ltd | Hospitality | 2024 |
| Ruth and Josh Entertainment Ltd | Arts & recreation | 2022 |
| Ryan HR Ltd | Professional & scientific | 2024 |
| S & B Brickwork NE Ltd | Construction | 2021 |
| S & JAY Building Solutions Ltd | Construction | 2026 |
| S & L Renewables Ltd | Manufacturing | 2021 |
| S a H Consultant Services Limited | Other services | 2017 |
| S J I Holdings Limited | Professional & scientific | 2005 |
| S&C Inside View Ltd | Health & social care | 2024 |
| S&G Joyce Properties Limited | Real estate | 2025 |
| S.E.A Subsea Inspections Ltd | Construction | 2020 |
| S.E.A. Consultants Limited | Professional & scientific | 2005 |
| S14W Holdings Limited | Professional & scientific | 2016 |
| Sabor Autentico Ltd | Wholesale & retail | 2025 |
| Safeproof Ltd | Financial services | 2021 |
| Sagacitas Limited | Financial services | 2025 |
| Sage Medical Aesthetics Ltd | Health & social care | 2024 |
| Sahn Estates Ltd | Real estate | 2026 |
| Sail Creative Ltd | Professional & scientific | 2018 |
| Salt Market Company Ltd | Wholesale & retail | 2019 |
| Sambram Limited | Professional & scientific | 2024 |
| Sambuca Boldon Ltd | Hospitality | 2023 |
| Sambuca Cafe Limited | Hospitality | 2005 |
| Sambuca Cassia Limited | Real estate | 2011 |
| Sambuca Durham(Ne) Limited | Hospitality | 2026 |
| Sambuca Italian Ltd | Hospitality | 2019 |
| Sambuca Percy Ltd | Hospitality | 2022 |
| Sammy Anne's Holistic Therapies Limited | Health & social care | 2022 |
| Sammy Anne's Products Ltd | Wholesale & retail | 2022 |
| Samuel New Ltd | Construction | 2019 |
| Sanael Enterprises Ltd | Real estate | 2023 |
| Sanctuary House NE Ltd | Other services | 2023 |
| Sander Consultants Limited | Financial services | 2007 |
| Sansec Development (Stevenage) Limited | Real estate | 2000 |
| Sansec Developments (Killingworth) Limited | Real estate | 2013 |
| Sansec Developments (Number 1) Ltd. | Construction | 2011 |
| Sansec Developments Ltd. | Construction | 2011 |
| Sansec Developments NS Limited | Construction | 2018 |
| Sansec Developments Trading 1 Limited | Real estate | 2019 |
| Sansec IH Limited | Construction | 2016 |
| Sansec IH1 Limited | Construction | 2014 |
| Saronyah Hair Design Limited | Other services | 2024 |
| Satcom Distribution Limited | Extraterritorial | 2001 |
| Satcom Global Aura Holdings Limited | Extraterritorial | 2016 |
| Satcom Global Aura Limited | Information & communication | 2016 |
| Satcom Global Limited | Information & communication | 2004 |
| Save OUR Planet Energy Group Limited | Professional & scientific | 2019 |
| Savvy ROW Limited | Wholesale & retail | 2019 |
| Sawtell Films Ltd | Information & communication | 2026 |
| Sbbc Limited | Wholesale & retail | 2026 |
| SBH HV Services Ltd | Construction | 2023 |
| SC Eduard-Transport Ltd | Wholesale & retail | 2020 |
| Scaff's UK Newcastle Limited | Wholesale & retail | 2026 |
| Scaretech Global Ltd | Manufacturing | 2016 |
| School Improvement Advisers Ltd | Professional & scientific | 2013 |
| School's OUT (Northern) Limited | Health & social care | 2002 |
| Scibertec Limited | Information & communication | 1996 |
| Science Developments Ltd | Professional & scientific | 2011 |
| Scissorboys Ltd | Other services | 2013 |
| Scorchio Ices Ltd | Hospitality | 2021 |
| Scott and Wilson Ltd | Hospitality | 2019 |
| Scott Developments NE Ltd | Real estate | 2024 |
| Scott Plumbing and Heating NE Ltd | Construction | 2024 |
| Scott Willoughby Plumbing & Heating Limited | Construction | 2014 |
| Scrappy’S Pet Crematorium Ltd | Other services | 2022 |
| Screenboo Productions Limited | Administrative & support | 2012 |
| Scrubology Ltd | Wholesale & retail | 2024 |