| SC Corporate Holdings Limited | Financial services | 2010 |
| SC Engineering Ltd | Professional & scientific | 2025 |
| SC Event Management Limited | Administrative & support | 2015 |
| Scafell Ltd | Information & communication | 2026 |
| Scaffold Superior Limited | Construction | 2025 |
| Scangrade Limited | | 1984 |
| Scarlet's House Limited | Real estate | 2024 |
| Scarreras Promotions Ltd | Arts & recreation | 2021 |
| Scenic (Services) Limited | Construction | 2011 |
| Scenic Air CON and Refrigeration Limited | Construction | 2021 |
| Scenic Caravan Sales Ltd | Wholesale & retail | 2020 |
| Scenic Park Homes Limited | Administrative & support | 2015 |
| Scented Rainbows Limited | Manufacturing | 2020 |
| Scents & Soaks Ltd | Wholesale & retail | 2024 |
| SCF Cooling LLP | | 2024 |
| SCG P&H Ltd | Construction | 2023 |
| Schj Limited | Real estate | 2026 |
| Scholamart Ltd | Real estate | 2025 |
| Schools' Sports Limited | Information & communication | 2006 |
| Schuster & Cambria Limited | Wholesale & retail | 2012 |
| Scicis Limited | Extraterritorial | 2002 |
| Scin Records Ltd | Wholesale & retail | 2025 |
| Scinde Court Management Company Limited | Households | 1988 |
| SCL Property Development Limited | Construction | 2015 |
| Scooters and Spares Limited | Wholesale & retail | 2009 |
| Scorpio Signs and Displays Limited | Professional & scientific | 2023 |
| Scott Gilbert Plastering & Building Contractors Ltd | Construction | 2014 |
| Scott Gormley Physiotherapy Limited | Health & social care | 2018 |
| Scott Liddle Consulting Ltd | Professional & scientific | 2022 |
| Scott Liddle Property Investments Ltd | Financial services | 2021 |
| Scottfernandez Estates Ltd | Real estate | 2021 |
| Scottfernandez Holdings Ltd | Financial services | 2021 |
| Scottfernandez Properties Ltd | Real estate | 2019 |
| Scout Coffee Roasters Ltd | Manufacturing | 2021 |
| Screen Scaffolding Services Ltd | Construction | 2025 |
| Scribble Inc Ltd | Professional & scientific | 2018 |
| Scribe Building Solutions Limited | Construction | 2021 |
| Sculptglass Limited | Wholesale & retail | 2020 |
| SD Accounting Ltd | Professional & scientific | 2021 |
| SD Builders Merchants Ltd | Wholesale & retail | 2017 |
| SD Maintenance Services Limited | Construction | 2005 |
| SD Wood Flooring Ltd | Wholesale & retail | 2012 |
| Sdap Enterprises Limited | Professional & scientific | 2017 |
| Sdcservicesuk Ltd | Professional & scientific | 2013 |
| SDL Aviation Limited | Wholesale & retail | 2024 |
| SDL Pneumatic & Industrial Supplies Limited | Wholesale & retail | 2006 |
| SDL Sawmills Limited | Manufacturing | 2023 |
| SDM Lettings Ltd | Real estate | 2025 |
| Sdms Holdings Ltd | Financial services | 2024 |
| Seacableconsultants Limited | Mining & quarrying | 2015 |
| Seaclose (Ryde) Ltd | Real estate | 2021 |
| Seaire Trading Limited | Real estate | 2015 |
| Sealant Systems Ltd | Construction | 2005 |
| Seamless Entertainment Limited | Information & communication | 2019 |
| Sean Mcgoldrick Limited | Arts & recreation | 2012 |
| Seaport Development Ltd | Administrative & support | 2007 |
| Seas Education Limited | Education | 2025 |
| Seasonal Showcase Ltd | Wholesale & retail | 2026 |
| Seatflow Ltd | Information & communication | 2024 |
| Seaver Environmental Consultancy Limited | Professional & scientific | 2024 |
| Seaview Bay Management Limited | Households | 1989 |
| Seaview Services Limited | Transport & logistics | 2023 |
| Sebam LLP | | 2021 |
| Second Chance (Newport) Limited | Wholesale & retail | 2025 |
| Secondwave International Ltd | Wholesale & retail | 2025 |
| Secret Retreat Limited | Other services | 2013 |
| Secrets Bakehouse Ltd | Hospitality | 2025 |
| Securanova Limited | Information & communication | 2024 |
| Secure Brickwork Ltd | Construction | 2018 |
| Secure Connect Plus+ Limited | Information & communication | 2025 |
| Secure Dimensions Limited | Professional & scientific | 2013 |
| Secure Windows and Doors Ltd | Construction | 2026 |
| Secureguide Limited | Professional & scientific | 2022 |
| Security Gateway Ltd | Administrative & support | 2025 |
| Security System Reclaim Ltd | Water & waste | 2018 |
| Sedbury Self Storage Limited | Real estate | 2012 |
| Seed Spells Ltd | Wholesale & retail | 2025 |
| Seeds of Hope - Integrating Neurodiversity C.I.C. | Education | 2026 |
| Seemole Ltd | Hospitality | 2014 |
| Segcorr Ltd | Professional & scientific | 2016 |
| Sehrish ALI Ltd | Wholesale & retail | 2026 |
| Selby Court (Teynham) Management Company Limited | Households | 2011 |
| Select Asbestos Surveys Ltd | Professional & scientific | 2023 |
| Select Cars Motor Company Ltd | Wholesale & retail | 2022 |
| Select Homes and Commercial Limited | | 1980 |
| Self HV Services Ltd | Construction | 2025 |
| Seller Tools Ltd | Information & communication | 2018 |
| Sellers Financial Services Ltd | Financial services | 2025 |
| Selsey View (Shanklin) Management Company Limited | Households | 2001 |
| Selwood Surveying Limited | Professional & scientific | 2009 |
| Selwyn Court Management Company Limited | Households | 1985 |
| Semiconductor Catapult Limited | Extraterritorial | 2026 |
| Senaptec (UK) Ltd | Health & social care | 2024 |
| Senior Shop Limited | Extraterritorial | 2013 |
| Sennybridge Ltd | Construction | 2010 |
| Sensagility Ltd | Administrative & support | 2023 |
| Sensia Systems Limited | Information & communication | 2001 |
| Sensor Investment Limited | Financial services | 2023 |
| Sensorium Chiropractic Ltd | Public administration | 2019 |
| Sensory Play Cafe Ltd | Hospitality | 2018 |