| S & Marriott Holdings Limited | Real estate | 2026 |
| S & P Building Services Limited | Construction | 2026 |
| S a Clayton Ltd | Health & social care | 2024 |
| S a Partners Services Limited | Professional & scientific | 2010 |
| S a Secure Limited | Wholesale & retail | 2003 |
| S and B Holdings Limited | Financial services | 2017 |
| S Charlesworth Ltd | Manufacturing | 2025 |
| S Corney Ltd | Professional & scientific | 2025 |
| S D Tanner Electrical Ltd | Construction | 2019 |
| S Dhillon Construction Limited | Real estate | 2023 |
| S Etheridge Contracting Limited | Agriculture & fishing | 2024 |
| S Evans Plant Hire Limited | Construction | 2003 |
| S Fletcher Consultancy Limited | Education | 2025 |
| S Greening Limited | Other services | 2003 |
| S J Carpentry & Home Improvements Ltd | Construction | 2024 |
| S J Edney Limited | Professional & scientific | 2011 |
| S N F Property Services Ltd | Households | 2022 |
| S Nicholson Properties Limited | Real estate | 2023 |
| S O'Callaghan Building & Plastering Ltd | Construction | 2018 |
| S Oneir Ltd | Hospitality | 2025 |
| S Reynolds Removals Limited | Transport & logistics | 2025 |
| S S Lettings Ltd | Real estate | 2023 |
| S W Catering Supplies Limited | Wholesale & retail | 2019 |
| S&D Cuisine Ltd | Hospitality | 2025 |
| S&D Motor & Recovery Services Ltd | Wholesale & retail | 2020 |
| S&E Properties Development Ltd | Construction | 2021 |
| S&E Shine Management Ltd | Real estate | 2026 |
| S&G Window Contractors Ltd | Manufacturing | 2025 |
| S&H Retail Limited | Wholesale & retail | 2019 |
| S&I Composite Solutions Ltd | Manufacturing | 2025 |
| S&S Developments IOW Ltd | Manufacturing | 2025 |
| S&S Horizon Ltd | Hospitality | 2024 |
| S. Folkes Memorials Limited | Manufacturing | 2011 |
| S.A. Partners LLP | | 2004 |
| S.E Estates Ltd | Real estate | 2025 |
| S.E.A. Star Investment Limited | Wholesale & retail | 2023 |
| S.Hincke Ltd | Transport & logistics | 2018 |
| S.J.M. Holdings (S.W.) Limited | Professional & scientific | 2008 |
| S.K. Carwash Ltd | Wholesale & retail | 2018 |
| S.T. Orphan & Co. Limited | Professional & scientific | 2008 |
| S.W.S Medical Solutions Ltd | Health & social care | 2024 |
| SA FOOD2 Ltd | Hospitality | 2024 |
| SA Global Investments Limited | Real estate | 2019 |
| SA Private Mortgage Solutions Limited | Financial services | 2026 |
| SA Supplements Ltd | Wholesale & retail | 2025 |
| Saan-Hub Solutions Limited | Manufacturing | 2024 |
| SAB191 Ltd | Hospitality | 2017 |
| Saber Projects Ltd | Professional & scientific | 2013 |
| Sable Engineering Ltd | Manufacturing | 2024 |
| Sabore Grill Ltd | Hospitality | 2025 |
| Sabre Software Development Limited | Manufacturing | 1995 |
| Sadaf Estates Limited | Real estate | 2023 |
| Sads Holdings Limited | Financial services | 2015 |
| Safari Media Ltd | Information & communication | 2023 |
| Safe Bidco Limited | Financial services | 2019 |
| Safe Group 17 Ltd | Real estate | 2020 |
| Safe Hands Mortgage and Protection Ltd | Financial services | 2021 |
| Safe Hands Properties and Investments Ltd | Real estate | 2020 |
| Safe Harbour Homes Ltd | Health & social care | 2026 |
| Safe Haven Support Solutions Ltd | Administrative & support | 2022 |
| Safe Midco Limited | Financial services | 2019 |
| Safe Plant Inspections Ltd | Professional & scientific | 2012 |
| Safe Shell Therapy Ltd | Health & social care | 2025 |
| Safe Topco Limited | Financial services | 2019 |
| Safe Trade Solutions Ltd | Information & communication | 2025 |
| Safe Water I.O.W Ltd | Professional & scientific | 2025 |
| Safefix Appliances Limited | Other services | 2026 |
| Safeguard Risk Consultants Ltd | Other services | 2025 |
| Safeguard Technologies Ltd | Health & social care | 2025 |
| Safesparks Electrical Limited | Construction | 2016 |
| Safety First Lifting Gear Services Limited | Wholesale & retail | 2005 |
| Safety Matters in Rail & Road Ltd | Construction | 2020 |
| Sage & Co Auctions Limited | Real estate | 2021 |
| Sage & Co Estate Agents Limited | Real estate | 2018 |
| Sagili Healthcare Limited | Health & social care | 2014 |
| Sahanli Barber Ltd | Other services | 2018 |
| Sahara International Group Ltd | Wholesale & retail | 2023 |
| SAHARA7.COM Ltd | Wholesale & retail | 2024 |
| Saharali Ltd | Wholesale & retail | 2025 |
| SAI Baba Limited | Wholesale & retail | 2014 |
| SAI South Indian Food Ltd | Hospitality | 2025 |
| SAI South Indian Ltd | Hospitality | 2026 |
| SAI Super Mart Ltd | Wholesale & retail | 2019 |
| Sailing Club Manager Limited | Information & communication | 2013 |
| Sailing Networks Limited | Information & communication | 2004 |
| Saimir Kastrati Limited | Transport & logistics | 2019 |
| Saint Brides Specialist Cars Ltd | Wholesale & retail | 2021 |
| Saint Vincent's Community Support Limited | Health & social care | 2012 |
| Saisubramanya Limited | Health & social care | 2025 |
| Saith Cantref CYF | Administrative & support | 2012 |
| Saiu Transport Ltd | Administrative & support | 2019 |
| Sajeel's Mart Ltd | Wholesale & retail | 2026 |
| Sajiali Ltd | Transport & logistics | 2020 |
| Sakoso Ltd | Professional & scientific | 2025 |
| Saleh Khan Locum Ltd | Health & social care | 2023 |
| Sales Bloom UK Limited | Information & communication | 2014 |
| Salim Property Management Limited | Real estate | 2017 |
| Salkara Catering and Events Ltd | Hospitality | 2026 |
| Sallar Food Ltd | Hospitality | 2024 |
| Sally Howe Permanent Cosmestics Ltd | Other services | 2017 |