| Currentage Enterprises Limited | Wholesale & retail | 2024 |
| Curry HUT (Newcastle) Limited | Hospitality | 2026 |
| Custom Logistics Ltd | Transport & logistics | 2025 |
| Custom Merch Ltd | Wholesale & retail | 2024 |
| Cyber Tranna Solutions Ltd | Information & communication | 2025 |
| Cyberkiln Estates Ltd | Real estate | 2021 |
| Cyclpac UK Ltd | Wholesale & retail | 2023 |
| Cygnets Placements and Training Limited | Education | 2023 |
| Cypress Hub Limited | Administrative & support | 2022 |
| D & E Property Services Ltd | Real estate | 2024 |
| D & P Doran Property Holdings Ltd | Real estate | 2024 |
| D B Property Solutions Limited | Construction | 2019 |
| D Murray Joinery Limited | Construction | 2014 |
| D Rainbow Property Limited | Real estate | 2019 |
| D T Askey Limited | Administrative & support | 2004 |
| D W I C Ltd | Professional & scientific | 2008 |
| D&M Maguire Ltd | Education | 2024 |
| D.Leadbetter Interiors Ltd | Manufacturing | 2020 |
| D.O Fit Outs Ltd | Construction | 2021 |
| D.W.A.C Ltd | Professional & scientific | 2007 |
| D4 Electrical Limited | Construction | 2012 |
| Dadson Lettings Ltd | Real estate | 2025 |
| Dadsons Lettings Ltd | Households | 2025 |
| Dahlia Health Care Ltd | Health & social care | 2021 |
| Daie Ltd | Manufacturing | 2026 |
| Daily Madness UK Limited | Information & communication | 2019 |
| Dalgarno Consulting Limited | Professional & scientific | 2015 |
| Daljit Constructions Ltd | Construction | 2026 |
| Damien Adair Asset Limited | Manufacturing | 2025 |
| Damton Consulting Limited | Professional & scientific | 2000 |
| DAN Mccourt Photography Ltd | Professional & scientific | 2024 |
| Daring Scientific Projects Limited | Professional & scientific | 2020 |
| Darryl Wright Limited | Administrative & support | 2004 |
| Dart Industrial Services Limited | Manufacturing | 2023 |
| Dartsman Limited | Wholesale & retail | 2025 |
| Datastor (North East) Limited | Transport & logistics | 2002 |
| Dataways Limited | Information & communication | 2021 |
| Dave Roberts Site Services Ltd | Professional & scientific | 2020 |
| David Newton Plumbing & Heating Ltd | Construction | 2011 |
| David.W.T. Birkin & Co Ltd. | Professional & scientific | 2003 |
| Davies and Reseigh Limited | Financial services | 2024 |
| Dawson Enterprises Limited | Wholesale & retail | 2025 |
| DB E-Commerce Club Ltd | Wholesale & retail | 2023 |
| DB Pubs Ltd | Hospitality | 2026 |
| Dbbk Accountants Ltd | Professional & scientific | 2018 |
| DC Audit Ltd | Information & communication | 2010 |
| DC Electrical North Ltd | Construction | 2021 |
| DC Offshore Ltd | Professional & scientific | 2026 |
| DC3 PEN Limited | Extraterritorial | 2013 |
| Dean Statham LLP | | 2003 |
| Debt Force Limited | Administrative & support | 2014 |
| Deck Joint Limited | Manufacturing | 2011 |
| Deco Board Limited | Wholesale & retail | 2025 |
| Decora Interiors Ltd | Manufacturing | 2014 |
| DEE & KAY Ltd | Health & social care | 2014 |
| Deganwy Flats Management Limited | Real estate | 1983 |
| Delia-T Ltd | Wholesale & retail | 2026 |
| Dellmont Enterprises Limited | Agriculture & fishing | 1998 |
| Delta Surgical Limited | Wholesale & retail | 2001 |
| Deltek Fire and Security Limited | Administrative & support | 2018 |
| Deluxe Lounge Ltd | Other services | 2024 |
| Deluxestays Ltd | Hospitality | 2022 |
| Demetae Secondary Ltd | Education | 2026 |
| DEN Developments Ltd | Construction | 2025 |
| Denmark House RTM Company Limited | Households | 2022 |
| DEP Pizza Ltd | Hospitality | 2026 |
| Derma Courses Limited | Health & social care | 2016 |
| Dermadoc Ltd | Health & social care | 2012 |
| Derwent Invest Ltd | Financial services | 2025 |
| Desai Medical Consultancy Limited | Health & social care | 2019 |
| Design Axis Ltd | Professional & scientific | 2024 |
| Designer Worktops Limited | Manufacturing | 2010 |
| Dessertsdeliveredbakery Ltd | Hospitality | 2018 |
| Detectadye Limited | Extraterritorial | 2016 |
| Devlin Butchers Ltd | Wholesale & retail | 2015 |
| Dewa Legal Services Limited | Professional & scientific | 2020 |
| Dewa Transport and Logistics Limited | Transport & logistics | 2025 |
| DH Recruitment Ltd | Administrative & support | 2017 |
| Dhani Midlands Limited | Health & social care | 2020 |
| Dhani Properties Midlands Limited | Real estate | 2023 |
| Dhmt Accounting Limited | Professional & scientific | 2019 |
| Diamond Cleaning and Maintenance Limited | Administrative & support | 2019 |
| Diamond Families CIC | Health & social care | 2013 |
| Diamond Gardens Apartments Management Company Limited | Households | 2018 |
| Diamond Lift Services Limited | Wholesale & retail | 1987 |
| Diamond P & H Ltd | Construction | 2014 |
| Diamond Wills and Estate Planning Ltd | Administrative & support | 2009 |
| Diane Mcdonough Financial Services Ltd | Financial services | 2025 |
| Diesel DYE Limited | Extraterritorial | 2008 |
| Diffractive Studio Ltd | Manufacturing | 2023 |
| Digiacomo Properties Ltd | Real estate | 2021 |
| Digipigeon Limited | Information & communication | 2007 |
| Digital Surveys Ltd | Professional & scientific | 2023 |
| Dioclé Coffee Ltd | Hospitality | 2023 |
| Direct Cars Newcastle Ltd | Transport & logistics | 2024 |
| Direct Data Analysis Ltd | Professional & scientific | 2010 |
| Direct Remarketing Limited | Other services | 2019 |
| Directa Plus PLC | Professional & scientific | 2003 |
| DIS Staffs Ltd | Wholesale & retail | 2019 |
| Disclosures and Barring Services Limited | Other services | 2012 |