| Stitch Clean NE Ltd | Other services | 2023 |
| Stixs Asian Kitchen Limited | Hospitality | 2022 |
| STN Power Products Limited | Manufacturing | 2024 |
| STN Power Systems Limited | Manufacturing | 2022 |
| STO Consulting Ltd | Professional & scientific | 2012 |
| Stockaisle Ltd | Information & communication | 2026 |
| Stockatrade Limited | Wholesale & retail | 2005 |
| Stockdale & Reid Limited | Extraterritorial | 2001 |
| Stockhelmer Limited | Education | 2016 |
| Stone & Luster Co. Ltd | Wholesale & retail | 2025 |
| Stone Cladding Company Ltd | Manufacturing | 2021 |
| Stone Meadow Trade Consultancy Ltd | Wholesale & retail | 2025 |
| Stone Rook Ltd | Real estate | 2021 |
| Stone Valley Solutions Limited | Information & communication | 2018 |
| Stonebridge Car Care Ltd | Wholesale & retail | 2026 |
| Stonebridge Motors North East Ltd | Wholesale & retail | 2020 |
| Stonebridge Training and Consultancy Limited | Professional & scientific | 2022 |
| Stonebrook Ventures Limited | Professional & scientific | 2025 |
| Stonecrop Vehicle Solutions Ltd | Administrative & support | 2023 |
| Stonegarth Monk Bretton Management Company Limited | Real estate | 2016 |
| Stonehill Engineering Limited | Manufacturing | 2006 |
| Stonehouse Lift Consultancy Limited | Professional & scientific | 2021 |
| Stoneplate Catering Company Ltd | Hospitality | 2025 |
| Stoneridge Hall Residents Management Company Limited | Real estate | 2024 |
| Stoneyard Holdings Ltd | Real estate | 2023 |
| Stonham Limited | Real estate | 2002 |
| Storey Sports Consultancy Limited | Professional & scientific | 2024 |
| Storied Past CIC | Arts & recreation | 2024 |
| Storm-Fitness Limited | Health & social care | 2010 |
| Storrar Marine Limited | Wholesale & retail | 2004 |
| Storymade Limited | Information & communication | 2020 |
| STR Management Services Limited | Extraterritorial | 1996 |
| Strachan Tyson & Hamilton Limited | Professional & scientific | 2000 |
| Stradale Ltd | Professional & scientific | 2016 |
| Straight Line Holdings North East Limited | Financial services | 2014 |
| Straightline (NE) Limited | Construction | 1980 |
| Straightline Properties NE Limited | Real estate | 2013 |
| Straker Paul Limited | Professional & scientific | 2024 |
| Stranding Ltd | Real estate | 2022 |
| Strands of Tyne Ltd | Other services | 2023 |
| Strange Llama Limited | Information & communication | 2018 |
| Strange Quark Ltd | Information & communication | 2022 |
| Strata Nostra Limited | Professional & scientific | 2012 |
| Strategic Finance (Commercial) Limited | Extraterritorial | 2005 |
| Strategic Finance Limited | Other services | 1994 |
| Strategic Services Ltd | Information & communication | 2020 |
| Stratford Orthodontics Limited | Health & social care | 2006 |
| Strattum Limited | Construction | 2017 |
| Strawberrylaneclothing Ltd | Wholesale & retail | 2026 |
| Strays Without Borders Dog Rescue CIC | Transport & logistics | 2024 |
| Stream Automotive (Tyneside) Ltd | Wholesale & retail | 2025 |
| Stream on Demand Limited | Administrative & support | 2016 |
| Streamslot Property Management Limited | Households | 1989 |
| Strebor Developments Limited | Construction | 2025 |
| Street Food Company (NE) Ltd | Hospitality | 2010 |
| Street Food Event Catering Ltd | Hospitality | 2021 |
| Street Food Jesmond Ltd | Hospitality | 2015 |
| Street Food NH Ltd | Wholesale & retail | 2024 |
| Street Food North East Ltd | Hospitality | 2016 |
| Street Logistics Ltd | Transport & logistics | 2025 |
| Street Pioneers Ltd | Hospitality | 2026 |
| Street Vending Ltd | Administrative & support | 2010 |
| Streets Systems Ltd | Information & communication | 2018 |
| Strenger Ltd | Professional & scientific | 2015 |
| Strettle of Newcastle Limited | Manufacturing | 1979 |
| Stretton Abodes Developments Ltd | Real estate | 2020 |
| Stretton Abodes Ltd | Real estate | 2018 |
| Strictly Regal Ltd | Hospitality | 2025 |
| Strictly Starters Limited | Arts & recreation | 2018 |
| Stride Business Support Ltd | Administrative & support | 2024 |
| Strikerate Limited | Extraterritorial | 1985 |
| Strikers Academy CIC | Arts & recreation | 2024 |
| Striveway Group Ltd | Financial services | 2023 |
| Strixon Ltd | Wholesale & retail | 2025 |
| Strocam Profiles Ltd | Manufacturing | 2012 |
| Strong Point Games Ltd | Manufacturing | 2021 |
| Stronghold 21 Ltd | Real estate | 2021 |
| Structural Consulting Limited | Professional & scientific | 2018 |
| Structural Works Construction Limited | Construction | 2026 |
| Strufire Ltd | Professional & scientific | 2024 |
| Stryde Accountancy Ltd | Professional & scientific | 2014 |
| STS Fish Ltd | Real estate | 2023 |
| Sttaa CIC | Transport & logistics | 2023 |
| Stuart Clegg Associates Limited | Professional & scientific | 2000 |
| Stuart White Ltd | Professional & scientific | 2026 |
| Student Accommodation (UK) Limited | Hospitality | 2011 |
| Student Care Bureau (International) Limited | Education | 2011 |
| Student Portal Limited | Real estate | 2018 |
| Student Property Limited | Real estate | 2018 |
| Student: SJN Training Ltd | Health & social care | 2018 |
| Students Solution Limited | Education | 2016 |
| Studio 28 Patisserie Ltd | Manufacturing | 2018 |
| Studio 3DI Ltd | Professional & scientific | 2024 |
| Studio ADE Ltd | Information & communication | 2022 |
| Studio Horn Limited | Professional & scientific | 2011 |
| Studio LP Creative Limited | Arts & recreation | 2017 |
| Studio Luxe Limited | Other services | 2024 |
| Studio Orange Creative Ltd | Information & communication | 2026 |
| Studio Oris Limited | Health & social care | 2024 |
| Studio Social North Ltd | Professional & scientific | 2025 |