| Stansfield House (Stanley) Limited | Real estate | 2017 |
| Stanton Hall Gardens and Nursery Ltd | Wholesale & retail | 2025 |
| Stanwick House Limited | Households | 2020 |
| Staple Industry Ltd | Wholesale & retail | 2023 |
| Star Builders NCL Ltd | Construction | 2025 |
| Star Company Newcastle Ltd | Other services | 2025 |
| Star Nails Junior Ltd | Other services | 2025 |
| Star Platinum Ltd | Hospitality | 2025 |
| Star Suites Limited | Real estate | 2022 |
| Star Tech Industries Limited | Arts & recreation | 2020 |
| Starbeck Deli Ltd | Hospitality | 2023 |
| Starbug Ltd | Hospitality | 2024 |
| Stare Decisis International Ltd | Education | 2024 |
| Starlight Print Ltd | Manufacturing | 2023 |
| Starline Property Group Limited | Real estate | 2016 |
| Starling Recruitment Ltd | Administrative & support | 2020 |
| Starlit Event Management Ltd | Arts & recreation | 2025 |
| Starmarket Premier Ltd | Wholesale & retail | 2024 |
| Stars Realty Ltd | Real estate | 2026 |
| Startech Internet Ltd | Information & communication | 2013 |
| Startupbooom Ltd | Professional & scientific | 2025 |
| Stashan Limited | Extraterritorial | 2020 |
| Stateplus Limited | Real estate | 2005 |
| Stateside Treat Emporium Limited | Wholesale & retail | 2016 |
| Station Automotive Limited | Wholesale & retail | 2025 |
| Station Residential Apartments Limited | Real estate | 2015 |
| Stature Property Unlimited | Real estate | 2014 |
| Status Marketing Limited | Professional & scientific | 2011 |
| Status Properties Group Ltd | Real estate | 2023 |
| Status Security Systems Ltd | Administrative & support | 2001 |
| Stay in Seahouses Ltd | Hospitality | 2019 |
| Stay Loop Limited | Households | 2026 |
| Stay Ouseburn Limited | Hospitality | 2026 |
| Staycation Escapes LLP | | 2023 |
| Staynor Hall Phase 3J (Selby) Management Company Limited | Real estate | 2014 |
| Staywise Home Ltd | Real estate | 2026 |
| STC Careers CIC | Professional & scientific | 2026 |
| STC Cleaning Services Ltd | Administrative & support | 2013 |
| Ste.Rope Access Ltd | Professional & scientific | 2025 |
| Steady Group Ltd | Administrative & support | 2026 |
| Steady Hands Interiors Ltd | Professional & scientific | 2021 |
| Steady Stone Homes Ltd | Real estate | 2025 |
| Sted Cross Management Limited | Professional & scientific | 2012 |
| Steel Frame Homes Ltd | Construction | 2014 |
| Stefania Gilca Limited | Administrative & support | 2017 |
| Stefans Sweets (N.E) Ltd | Hospitality | 2020 |
| Stellar Transport Services 3011 Ltd | Transport & logistics | 2025 |
| Stellarox Properties Ltd | Real estate | 2026 |
| Stelling LLP | | 2006 |
| Stelrad Group PLC | Manufacturing | 2021 |
| Stelrad Radiator Group Limited | Professional & scientific | 2014 |
| Stem Select Ltd | Administrative & support | 2024 |
| Step by Step Properties Limited | Administrative & support | 2023 |
| Stephen Carter Decorating Limited | Construction | 2003 |
| Stephen Easten Limited | Wholesale & retail | 1906 |
| Stephen Nelson Limited | Administrative & support | 2004 |
| Stephen Oliver Civil Engineering Limited | Administrative & support | 2014 |
| Stephen Taylor Associates Limited | | 1975 |
| Stephen Willis Limited | Wholesale & retail | 2021 |
| Stephenson Coates Audit Limited | Professional & scientific | 2018 |
| Stephenson Coates Limited | Professional & scientific | 2010 |
| Stephenson Court Residents Limited | Real estate | 1992 |
| Stephenson Hotel Enterprise Limited | Construction | 2012 |
| Stephenson Penshaw Ventures Ltd | Financial services | 2026 |
| Stephenson Quarter Developments Limited | Construction | 2004 |
| Stephenson Rocket Limited | Construction | 2012 |
| Stephenson Stappard Limited | Administrative & support | 2024 |
| Stephenson-Mohl Group Limited | Professional & scientific | 2017 |
| Stepney Lane (Newcastle) Limited | Real estate | 2022 |
| Stepney POP UP Shops Ltd | Real estate | 2025 |
| Stepping Stone New Homes Limited | Households | 2025 |
| Steps Support Residential Limited | Health & social care | 2025 |
| Steri-Bottle UK Limited | Wholesale & retail | 1999 |
| Sterling Brick Property Private Ltd | Real estate | 2026 |
| Sterling Developments and Lettings Ltd | Construction | 2024 |
| Sterling Edge Hospitality and Consultancy Ltd | Hospitality | 2026 |
| Sterling House Solutions Limited | Professional & scientific | 2005 |
| Sterling IT Solutions Ltd | Construction | 2019 |
| Sterling Pathway Limited | Financial services | 2025 |
| Sterling Property Portfolio Limited | Real estate | 1998 |
| Sterling Residential Services Limited | Professional & scientific | 2026 |
| Sterling Solutions IT Ltd | Information & communication | 2022 |
| Sterling Tower Ltd | Construction | 2024 |
| Sterry Sports and Fitness Limited | Arts & recreation | 2021 |
| Steve Harris Consultancy Ltd | Information & communication | 2010 |
| Steve Hughes Associates Limited | Real estate | 2010 |
| Steve Walker Interiors Ltd | Other services | 2015 |
| Steven Dunn 44 Ltd | Arts & recreation | 2022 |
| Steven Llewellyn Consulting Ltd | Professional & scientific | 2026 |
| Steven P Jones Limited | Financial services | 2014 |
| Stevens Fitness Limited | Arts & recreation | 2025 |
| Stewart Eyecare Ltd | Wholesale & retail | 2014 |
| Stewart Lettings Limited | Real estate | 2025 |
| Stfm Ltd | Construction | 2016 |
| STH Global Ltd | Wholesale & retail | 2024 |
| Stich Deliver Ltd | Transport & logistics | 2025 |
| Stickland EYE Care Limited | Health & social care | 2008 |
| Stickley Plant Hire Ltd | Construction | 2005 |
| Sticks & Sake Limited | Hospitality | 2025 |
| Stirling Property Development Ltd | Real estate | 2025 |