| Serviced Offices North Limited | Real estate | 2026 |
| SET Go Ltd | Hospitality | 2026 |
| SET Properties Group Ltd | Real estate | 2025 |
| SEV Trade Ltd | Wholesale & retail | 2022 |
| Seven Hills Health Limited | Health & social care | 2019 |
| Seven Shirts Ltd | Wholesale & retail | 2024 |
| Seven Stories Trading Limited | Arts & recreation | 2001 |
| Seven Stories, the National Centre for Children’S Books Limited | Education | 1996 |
| Seven Tankerville Management Limited | Households | 1985 |
| Seven Terraces Sourcing Ltd | Real estate | 2026 |
| Seven Triangle Limited | Real estate | 2015 |
| Sevenbridge London Limited | Real estate | 2019 |
| Seventhree Productions Limited | Information & communication | 2016 |
| Severus Properties Limited | Real estate | 2022 |
| Sevron Ltd | Information & communication | 2007 |
| Sewadeus Limited | Professional & scientific | 2016 |
| Seymour IT Operations Limited | Information & communication | 2010 |
| SF Racewear Ltd | Manufacturing | 2023 |
| SF Software Limited | Information & communication | 2005 |
| SF VI Ltd | Real estate | 2023 |
| SFK Pharm Ltd | Health & social care | 2020 |
| SFN Events Ltd | Arts & recreation | 2021 |
| SFT Trading Ltd | Construction | 2025 |
| Sfzha Ltd | Real estate | 2026 |
| SG Blount ST Convenience Stores Ltd | Wholesale & retail | 2024 |
| SG Property Renovations Ltd | Construction | 2014 |
| SG Vision Global Limited | Financial services | 2023 |
| SG Vision Investment Limited | Real estate | 2023 |
| SG Vision Limited | Health & social care | 2022 |
| Sg&H Electrical Ltd | Construction | 2007 |
| Sgdg Limited | Real estate | 2020 |
| Sgel Limited | Construction | 2025 |
| SGF Offshore Marine Electrical and Electronic Maintenance Services Ltd | Manufacturing | 2018 |
| SGG NE Limited | Wholesale & retail | 2022 |
| SGG Property Developments Limited | Hospitality | 2002 |
| Sgic Ltd | Construction | 2017 |
| SGJ Caravan, Motorhome and Trailer Servicing Ltd | Wholesale & retail | 2024 |
| Sgpm (NE) Limited | Construction | 2024 |
| SH (North) Limited | Administrative & support | 2025 |
| SH Haulage Limited | Transport & logistics | 2026 |
| SH Heating and GAS Ltd | Construction | 2022 |
| SH Properties & Estates Ltd | Financial services | 2024 |
| SH Property Lettings Ltd | Real estate | 2020 |
| SHA Market Ltd | Wholesale & retail | 2024 |
| Shaam Barbers Ltd | Other services | 2024 |
| Shaam Ventures Limited | Wholesale & retail | 2026 |
| Shaami's Sauces and Spices Limited | Wholesale & retail | 2023 |
| Shaan Sadiq Logistics Ltd | Transport & logistics | 2025 |
| Shaba Ltd | Hospitality | 2017 |
| Shabilla Property Investments Ltd | Real estate | 2026 |
| Shackville Ltd | Information & communication | 2019 |
| Shad Shawarma Ltd | Hospitality | 2023 |
| Shadi Events N.E Ltd | Wholesale & retail | 2025 |
| Shafak Ltd | Transport & logistics | 2022 |
| Shah Medical Services Limited | Health & social care | 2014 |
| Shah, Bayat & Partners Ltd | Professional & scientific | 2024 |
| Shahe Gosforth Ltd | Wholesale & retail | 2010 |
| Shaheen Properties Northeast Ltd | Real estate | 2024 |
| Shahi Frozen Foods Ltd | Hospitality | 2000 |
| Shahir Global Trading Ltd | Wholesale & retail | 2024 |
| Shahjee 313 Investments Limited | Real estate | 2025 |
| Shakerbone Construction Ltd | Construction | 2018 |
| Shakirul Alam Pictures Limited | Information & communication | 2012 |
| Shalimar Cowgate Ltd | Hospitality | 2018 |
| Shamsul Properties Limited | Real estate | 2022 |
| Shana Heaven Limited | Real estate | 2025 |
| Shanghai Tornado Culture Communication Co. UK Ltd | Professional & scientific | 2021 |
| Shanks Bell & Partners Limited | Professional & scientific | 2024 |
| Shantazz Global Limited | Hospitality | 2023 |
| Shanti BEE Community Interest Company | Other services | 2015 |
| Shape Adaptations Limited | Construction | 2012 |
| Shape Technical Consulting Ltd. | Information & communication | 2021 |
| Shapes Castle Stairs Ltd | Wholesale & retail | 2025 |
| Shaping Logic Ltd | Information & communication | 2023 |
| Shared Interest Foundation | Professional & scientific | 2003 |
| Shark Club (UK) Limited | Hospitality | 2010 |
| Sharma Plus Associates Limited | Health & social care | 2015 |
| Sharpe Ventures (North East) LLP | | 2012 |
| Sharpset Properties LLP | | 2012 |
| Shasai Limited | Real estate | 2025 |
| Shashi Properties Limited | Real estate | 2025 |
| Shaun Cullen Roofing NE Ltd | Construction | 2022 |
| Shaun Dack Logistics Ltd | Transport & logistics | 2025 |
| Shaun Ramsey Construction (North East) Limited | Construction | 2008 |
| Shaun Ramsey Holdings Limited | Administrative & support | 2020 |
| Shaunmc Fabrications Ltd | Manufacturing | 2016 |
| Shaw & Company Solicitors Limited | Professional & scientific | 2008 |
| Shaw 55 Ltd | Professional & scientific | 2024 |
| Shaw Home Improvements (NE) Limited | Construction | 2014 |
| Shawarma and Grill House Ltd | Wholesale & retail | 2024 |
| Shayne Anson Property Ltd | Manufacturing | 2019 |
| Shazam Consultancy Ltd | Professional & scientific | 2025 |
| Shazia Noor Ltd | Real estate | 2023 |
| Shazzy's Trading Limited | Wholesale & retail | 2018 |
| SHD Properties Ltd | Real estate | 2019 |
| SHE LET Go Ltd | Wholesale & retail | 2022 |
| Sheara's Fast Food Limited | Real estate | 2010 |
| Shearwater Properties (North East) Limited | Construction | 2015 |
| Shebas Newcastle Limited | Hospitality | 2024 |
| Sheepdog Consulting Limited | Other services | 2014 |