| Roboforge Ltd | Information & communication | 2025 |
| Robot Teddy Limited | Information & communication | 2017 |
| Robson & Robson Ltd | Professional & scientific | 2023 |
| Robson and Redpath Limited | Real estate | 2013 |
| Robson Brown International Ltd | Professional & scientific | 2020 |
| Robson Electrical Limited | Construction | 1996 |
| Robson Laidler (Durham) Limited | Professional & scientific | 1998 |
| Robson Laidler Accountants Limited | Professional & scientific | 2015 |
| Robson Laidler Financial Planning Limited | Financial services | 2005 |
| Robson Legal Ltd | Health & social care | 2018 |
| Robson Plumbing & Heating Limited | Construction | 2009 |
| ROC Studio Collective Ltd | Arts & recreation | 2025 |
| Rock & Soul Ltd | Wholesale & retail | 2025 |
| Rock Warehouse Limited | Wholesale & retail | 2008 |
| Rockhaven (P8 Cabot) Management Company Limited | Households | 2023 |
| Rockhaven (Salisbury) Management Company Limited | Households | 2021 |
| Rockhaven (Street) Management Company Limited | Households | 2022 |
| Rockhaven (Westbury) Management Company Limited | Households | 2019 |
| Rockwell Sharp Property Investments Ltd | Real estate | 2022 |
| Rockwell-Journey Ltd | Hospitality | 2023 |
| Rocz Ltd | Wholesale & retail | 2020 |
| Rodley Enterprises Limited | Other services | 2026 |
| Roff Consulting Limited | Professional & scientific | 2025 |
| Roff Property Limited | Real estate | 2024 |
| Roger Edwardson Education and Childrens Services Limited | Education | 2005 |
| Roger Mackintosh Consultancy Ltd | Professional & scientific | 2010 |
| Rogers Development Group Limited | Real estate | 2021 |
| Rogers Pipe Installation Ltd | Construction | 2025 |
| Rogue Rollers Ltd | Construction | 2026 |
| Roho Rafiki Limited | Wholesale & retail | 2020 |
| Roisin Crane Neurodevelopmental Ltd | Health & social care | 2026 |
| Rokewi Accountancy Limited | Professional & scientific | 2026 |
| Roland Burgess Limited | Wholesale & retail | 1922 |
| Rollapole Ltd | Professional & scientific | 2018 |
| Roller Coaster Group Limited | Administrative & support | 2024 |
| Roller Coaster TM Limited | Construction | 2020 |
| Rolling Mill Courtyard Management Limited | Real estate | 2005 |
| Roma Access Newcastle Upon Tyne Association C.I.C. | Education | 2018 |
| Roma Holocaust Memorial Centre -Newcastle Upon Tyne C.I.C. | Education | 2023 |
| Roma Newcastle Limited | Hospitality | 2024 |
| Roma Right Path Project CIC | Education | 2021 |
| Romarch Ltd | Construction | 2025 |
| Romastone Bathrooms Limited | Wholesale & retail | 2025 |
| Rombase Media Limited | Information & communication | 2002 |
| Romco Group Ltd | Manufacturing | 2016 |
| Romeo's Italian Limited | Hospitality | 2017 |
| Romeo's Pizza NCL Ltd | Hospitality | 2025 |
| Romi Barbers Limited | Other services | 2025 |
| Romildas Removals Ltd | Transport & logistics | 2017 |
| Romul Enterprises Limited | Real estate | 2019 |
| Ronald James Contract Ltd | Administrative & support | 2019 |
| Ronden Builders Limited | Construction | 1983 |
| Rongsheng Takeaway Ltd | Hospitality | 2024 |
| Ronsbrook Services Limited | Real estate | 1995 |
| Roof Solve UK Limited | Construction | 2015 |
| Roof US Ltd | Real estate | 2025 |
| Roofing Repairs Building & Landscaping Ltd | Construction | 2025 |
| Rooflight Architectural Ltd | Manufacturing | 2006 |
| Roofwyse Limited | Professional & scientific | 2026 |
| Rook Residential Property Ltd | Real estate | 2023 |
| Rookery Properties Limited | Hospitality | 2013 |
| Room 6 Media Ltd | Information & communication | 2022 |
| Rooted Flowers Limited | Wholesale & retail | 2021 |
| Rooted Motion CIC | Professional & scientific | 2026 |
| Rooted Properties North East Ltd | Real estate | 2022 |
| Roots and Tongues Ltd | Administrative & support | 2025 |
| Roots and Wings (Newcastle) Community Interest Company | Professional & scientific | 2008 |
| Roots Fitness Limited | Arts & recreation | 2018 |
| Roozy Ltd | Hospitality | 2017 |
| Rope Access England Ltd | Construction | 2017 |
| Rorcas Ltd | Professional & scientific | 2023 |
| Roro Consulting Ltd | Professional & scientific | 2018 |
| Roro Property Services Ltd | Real estate | 2022 |
| Rory Patrick Academy CIC | Arts & recreation | 2025 |
| Rosa Byanca 2 Ltd | Hospitality | 2024 |
| Rosco (Portland Road) Limited | Construction | 2006 |
| Rosco Property Group Limited | Construction | 2002 |
| Rosco Sterling House Limited | Real estate | 2017 |
| Rose a Ltd | Other services | 2022 |
| Rose Gold Beauty Limited | Education | 2018 |
| Rose House Alnmouth Ltd | Real estate | 2023 |
| Rose Plastering Ltd | Construction | 2025 |
| Rose Street Food Ltd | Hospitality | 2023 |
| Roseanna Grace Limited | Health & social care | 2018 |
| Rosebay Management Ltd | Real estate | 2021 |
| Rosebay Residential Ltd | Real estate | 2026 |
| Roseberry Park (Pelton) Management Company Limited | Real estate | 2012 |
| Rosecherry Limited | Wholesale & retail | 2023 |
| Roseframe Limited | Real estate | 1996 |
| Rosemount (Whitley Bay) Management Company Limited | Real estate | 1995 |
| Rosemount Technical Ltd | Professional & scientific | 2017 |
| Rosen(Uk) Limited | Professional & scientific | 1996 |
| Roseville (Dacre) Limited | Transport & logistics | 2014 |
| Roseville (Hillgate) Limited | Real estate | 2014 |
| Roseville (the Paddock) Limited | Construction | 2014 |
| Roseville Asset Management Limited | Construction | 2009 |
| Rosewood Care LLP | | 2008 |
| Rosewood HR Services Ltd | Administrative & support | 2013 |
| Rosewood Joinery and Building Ltd | Construction | 2024 |
| Rosher Ltd | Information & communication | 2015 |