| Radwell International- Europe Limited | Real estate | 2010 |
| Radwell International- UK Limited | Manufacturing | 2010 |
| Radwood Hall Farm Limited | Agriculture & fishing | 2010 |
| Rael Brook (Group) Limited | Wholesale & retail | 2023 |
| RAM Residential Property Services Limited | Real estate | 2021 |
| RAP Properties Limited | Real estate | 2009 |
| Raparu Consult CIC | Education | 2022 |
| Raphael KPS Limited | Construction | 2022 |
| Raven & Co Recovery Ltd | Administrative & support | 2007 |
| Rawlins Motor Parts Limited | Wholesale & retail | 2020 |
| RBK Accountants Limited | Professional & scientific | 2017 |
| RE Think Productivity Consulting Ltd | Information & communication | 2011 |
| Recruitment Plus Health & Care Limited | Administrative & support | 2019 |
| Red ASH Solutions Ltd | Construction | 2025 |
| Reedport Limited | Hospitality | 1992 |
| Refreshing Options Limited | Wholesale & retail | 2013 |
| Refreshing Options to Go Limited | Wholesale & retail | 2013 |
| Reimagine Education Limited | Extraterritorial | 2014 |
| Renovate My Property Ltd | Administrative & support | 2019 |
| Retail Solutions Trustees Limited | Professional & scientific | 2015 |
| Revtech Limited | Wholesale & retail | 1995 |
| Rfnb Limited | Financial services | 2025 |
| Rheumadoc Limited | Health & social care | 2019 |
| Riceyman Court Management Limited | Households | 2006 |
| Richard Jacobs Pension and Trustee Services Limited | Financial services | 1992 |
| Ridgway Caterers Limited | Hospitality | 2017 |
| Ridgway Chorlton Limited | Administrative & support | 2009 |
| Rigger Rock Venue Limited | Hospitality | 2013 |
| Ripponden Property Limited | Real estate | 2018 |
| Rishworth Developments Limited | Construction | 2017 |
| RL Project Delivery Ltd | Construction | 2024 |
| RLD Civil Engineering Services Limited | Professional & scientific | 2018 |
| RNR Spares Limited | Wholesale & retail | 2016 |
| Roberts Family Investment Holdings Ltd | Financial services | 2026 |
| Robin RB Limited | Professional & scientific | 2016 |
| Rockett Home Rentals Limited | Real estate | 2003 |
| Rockfield Consulting Limited | Information & communication | 2018 |
| Roltech Mechanical Limited | Extraterritorial | 2018 |
| Roofcare (North Staffs) Ltd | Construction | 2012 |
| Room 44 Properties Ltd | Real estate | 2021 |
| Roots to Recovery OT Services Ltd | Health & social care | 2025 |
| Rosacle Consultancy Limited | Health & social care | 2015 |
| Rose Holdings Ltd | Real estate | 2022 |
| Rose MAY Properties Limited | Real estate | 2020 |
| Rossisle Development Co. Limited | Construction | 1965 |
| Rowe Farm Limited | Agriculture & fishing | 2011 |
| RPE Face Fit Solutions Limited | Professional & scientific | 2011 |
| RRR Entertainment Ltd | Arts & recreation | 2018 |
| Rrsh Consultants Ltd | Construction | 2019 |
| RTS Trucks Limited | Manufacturing | 2022 |
| Rufus Estates Limited | Real estate | 2001 |
| Runway Management Ltd | Administrative & support | 2010 |
| Rushkeep Solutions Limited | Information & communication | 2017 |
| Rustage Family Holdings Ltd | Financial services | 2026 |
| RWM Commercial Services Limited | Administrative & support | 2019 |
| S H P Developments Limited | Construction | 2011 |
| S. Higgins Consultancy Ltd | Professional & scientific | 2024 |
| S.D.D.M.C. Limited | Professional & scientific | 2025 |
| S2 Management Ltd | Real estate | 2014 |
| S2 Trading Companies Ltd | Real estate | 2015 |
| SA Media Limited | Arts & recreation | 2021 |
| Sabjim Limited | Health & social care | 2015 |
| Safe Hands England Limited | Real estate | 2017 |
| Safety First Group Limited | Professional & scientific | 2015 |
| Safety First Hire & Analytics Limited | Administrative & support | 2018 |
| Safety First Protective Equipment Limited | Wholesale & retail | 2019 |
| SAL Scaffolding Limited | Construction | 2026 |
| Salon Geoffrey Limited | Other services | 2002 |
| Salt + Pepper Architecture Ltd | Professional & scientific | 2025 |
| Sanders Garden and Home Maintenance Limited | Administrative & support | 2024 |
| Sandy Lane Homes Limited | Construction | 2018 |
| SC Leisure Holdings Ltd | Hospitality | 2018 |
| Scribed Interiors Ltd | Wholesale & retail | 2022 |
| Sculpted Grooming Ltd | Professional & scientific | 2023 |
| SD Property Holdings Ltd | Real estate | 2024 |
| Seabridge Services Limited | Construction | 2020 |
| Sean Beck & Sides Limited | Other services | 2019 |
| Second Dynamics Limited | Information & communication | 2011 |
| Secret Skin & Laser Clinic Ltd | Administrative & support | 2016 |
| Seraphic (PVT) Ltd | Health & social care | 2018 |
| Serendipity Bridal (Staffordshire) Limited | Wholesale & retail | 2022 |
| Servet Holdings Limited | Administrative & support | 2023 |
| SGB World Service Limited | Construction | 2008 |
| SGS Trade Limited | Wholesale & retail | 2013 |
| Shakti Medicals Ltd | Health & social care | 2019 |
| Shanta Investments Ltd | Real estate | 2024 |
| Shaw Legal Services Limited | Professional & scientific | 2018 |
| Shaw Projects Industrial Services Ltd | Construction | 2024 |
| Sherlock Homes Letting Agents Limited | Real estate | 2006 |
| Shield House Agri Limited | Other services | 2025 |
| Shifters Light Haulage Limited | Transport & logistics | 2022 |
| Shigri Trading Ltd | Wholesale & retail | 2024 |
| Shiro Consultancy Limited | Professional & scientific | 2019 |
| SHO Building and Property Services Limited | Construction | 2024 |
| SHO Properties Limited | Real estate | 2024 |
| Sigmasixjv Limited | Construction | 2020 |
| Silabena Limited | Health & social care | 2022 |
| Silver and Silver LLP | | 2014 |
| Silver Tree Home Support Community Interest Company | Health & social care | 2012 |
| Silverdale Estates Limited | Real estate | 1962 |