| Smsk Management Consultancy Limited | Professional & scientific | 2016 |
| SN & GT Properties Ltd | Construction | 2019 |
| Snap Box Catering Limited | Hospitality | 2023 |
| SNI Property Limited | Real estate | 2023 |
| SO Sales Limited | Other services | 2017 |
| SOA Vision Limited | Wholesale & retail | 2025 |
| Sober Flourish Limited | Health & social care | 2023 |
| Social Asking UK Ltd | Professional & scientific | 2023 |
| Social Work Expertise Ltd | Health & social care | 2022 |
| Social Work Reports Limited | Health & social care | 2011 |
| Sockeye Capital Ltd | Real estate | 2023 |
| Softtop Surfacing Limited | Construction | 2024 |
| Soha International Limited | Wholesale & retail | 2023 |
| Soha Medical Limited | Health & social care | 2025 |
| Solar Sales Accelerator Ltd | Professional & scientific | 2026 |
| Soley Creative Limited | Professional & scientific | 2021 |
| Solis Tractors UK Limited | Wholesale & retail | 2015 |
| Solo-Link Ltd | Information & communication | 2023 |
| SOLUTION208 Limited | Administrative & support | 2014 |
| Something Wild Group Limited | Financial services | 2025 |
| Something Wild Operations Limited | Financial services | 2025 |
| Something Wild Properties Limited | Financial services | 2025 |
| Sonala Limited | Professional & scientific | 2022 |
| Sonder Trading Ltd | Wholesale & retail | 2019 |
| Sophro Ltd | Professional & scientific | 2008 |
| Sopsiq Ltd | Professional & scientific | 2019 |
| Soraya DJ Limited | Information & communication | 2026 |
| Sound Advice Education Limited | Education | 2017 |
| South Notts Surfacing Ltd | Construction | 2020 |
| Southbeck Homes Limited | Real estate | 2022 |
| Southern Property Management Limited | Real estate | 2012 |
| Southern Right Capital Limited | Professional & scientific | 2016 |
| Southfield Design Limited | Professional & scientific | 2010 |
| Southfield Engineering Limited | Professional & scientific | 2026 |
| Southwell and District Agricultural Society | Other services | 1992 |
| Southwell Carpentry Ltd | Construction | 2023 |
| Southwell Equine Assisted Learning Limited | Education | 2020 |
| Southwell Executive Chauffeuring Limited | Transport & logistics | 2004 |
| Southwell Solutions Ltd | Information & communication | 2015 |
| Spacebytz Ltd | Manufacturing | 2024 |
| Spaces to LET Ltd | Real estate | 2005 |
| Spark Developments Motorsport Ltd | Wholesale & retail | 2017 |
| Spark Interaction Ltd | Education | 2026 |
| Sparkling Solutions Limited | Information & communication | 2023 |
| Specialist Finishers Ltd | Construction | 2007 |
| Specialist Storage Services Ltd | Transport & logistics | 2024 |
| Specialist Trailer Services UK Limited | Wholesale & retail | 2015 |
| Specialist Tutor and Assessment Network Limited | Education | 2018 |
| Spectra Consultancy Ltd | Administrative & support | 2018 |
| Speedy Project Solutions Ltd | Professional & scientific | 2014 |
| Speedy Sharks Swim School Limited | Education | 2019 |
| Spencer & Stewart Ltd | Construction | 2020 |
| SPF Commercials Ltd | Wholesale & retail | 2020 |
| Sphere Agency Ltd | Professional & scientific | 2024 |
| SPI Marine (UK) Limited | Transport & logistics | 2014 |
| SPI Marine SPV (UK) Limited | Information & communication | 2023 |
| Spicebytz LLP | | 2024 |
| Spike Photography Ltd | Professional & scientific | 1999 |
| Spikings Data Solutions Ltd | Information & communication | 2015 |
| Spindean Limited | Extraterritorial | 2001 |
| Spire View Business Solutions Ltd | Professional & scientific | 2013 |
| Spire View Studio Ltd | Other services | 2024 |
| Spirit Embassy Ltd | Manufacturing | 2014 |
| Spirit of Trent Limited | Wholesale & retail | 2020 |
| Spores N Sprouts Ltd | Agriculture & fishing | 2024 |
| Spot on Smart Repairs Limited | Wholesale & retail | 2019 |
| Spray Captain Ltd | Construction | 2024 |
| Springwood Tree Services (Thorney) Ltd | Agriculture & fishing | 2014 |
| SPS Roofing Ltd | Construction | 2026 |
| Spud & BUN Ltd | Hospitality | 2026 |
| SPV1 Limited | Financial services | 2011 |
| SPV2 Limited | Real estate | 2011 |
| SRC Agent Limited | Other services | 2019 |
| SRF Music Publishing Limited | Information & communication | 2021 |
| SRM Connects Software Solutions Ltd | Information & communication | 2025 |
| SRW Consulting Ltd | Professional & scientific | 2026 |
| SS Electrical Solutions Ltd | Manufacturing | 2018 |
| SS Property Solutions Limited | Real estate | 2020 |
| SSC Joinery Ltd | Construction | 2021 |
| Ssco Communications Limited | Wholesale & retail | 2014 |
| Ssxz Limited | Wholesale & retail | 2025 |
| ST Mary's Rooms Property Management Company Limited | Households | 2019 |
| ST Rope Solutions Ltd | Construction | 2022 |
| ST. George's House (Harrogate) Management Company Limited | Households | 1987 |
| ST. George's Trust | Arts & recreation | 1997 |
| ST. Vincent Mill Residents Association Limited | Households | 2001 |
| Stables Farming Ltd | Agriculture & fishing | 2024 |
| Stablesafe Limited | Real estate | 2024 |
| Stack Inspection Services Limited | Professional & scientific | 2006 |
| Stacked Grantham Limited | Hospitality | 2026 |
| Stackyard Holding Ltd | Wholesale & retail | 2025 |
| Stainforth Service & Surveying Ltd | Professional & scientific | 2023 |
| Staley Group Limited | Real estate | 1992 |
| Stallion Enterprises Limited | Hospitality | 2018 |
| Stallion Residential Limited | Construction | 2025 |
| Stamford & Webster Limited | Professional & scientific | 2019 |
| Stan the Sweep Limited | Administrative & support | 2011 |
| Stanley Biggs Clothiers Ltd | Wholesale & retail | 2023 |
| Stark Estate Ltd | Real estate | 2026 |
| Starscale Ltd | Professional & scientific | 2023 |