| Shelbourns Ltd | Transport & logistics | 2022 |
| Shelford Investment Property Limited | Real estate | 2003 |
| Shelley Recruitment Limited | Administrative & support | 2024 |
| Shelley Ward Consultancy Ltd | Professional & scientific | 2019 |
| Sherwood Brick Cutting Limited | Manufacturing | 2015 |
| Sherwood Canopy Limited | Financial services | 2025 |
| Sherwood Decorators Ltd | Construction | 2014 |
| Sherwood Developments Ltd | Construction | 2019 |
| Sherwood Developments Projects Limited | Construction | 2023 |
| Sherwood Group Ltd | Professional & scientific | 2017 |
| Sherwood Hotels Limited | | 1983 |
| Sherwood Laboratories Limited | Professional & scientific | 1983 |
| Sherwood Lodge Property Management Limited | Households | 2014 |
| Sherwood Motors Limited | Wholesale & retail | 2024 |
| Sherwood Technical Services Limited | Administrative & support | 2000 |
| Sherwood Windows Limited | Manufacturing | 1991 |
| Shibolet Holdings Limited | Real estate | 2024 |
| Shipley Scaffolding Services Limited | Construction | 2022 |
| Shire Holidays Ltd | Hospitality | 2021 |
| Shires Medical Services Ltd | Health & social care | 2024 |
| Shires Trading Ltd | Wholesale & retail | 2020 |
| Shirleycroft Management Company Limited | Households | 2025 |
| Shleepi Limited | Manufacturing | 2026 |
| Shoker Holdings Limited | Real estate | 2019 |
| Shop 4 U Bilsthorpe Ltd | Wholesale & retail | 2020 |
| Shop Newark Limited | Wholesale & retail | 2020 |
| Shop Safe Online Today Limited | Wholesale & retail | 2025 |
| Shop Safer Online Limited | Wholesale & retail | 2025 |
| Shopai Ltd | Information & communication | 2024 |
| Shoreditch Solutions Limited | Arts & recreation | 2014 |
| Shotstone Limited | Other services | 1976 |
| SIECOS01 Limited | Administrative & support | 2021 |
| Sigea Holdings Limited | Financial services | 2024 |
| Sigma Bidco Limited | Financial services | 2022 |
| Sigma Estates Group Ltd | Real estate | 2021 |
| Sigma Midco 1 Limited | Financial services | 2022 |
| Sigma Midco 2 Limited | Financial services | 2022 |
| Sigma Topco Limited | Financial services | 2022 |
| Signature Land and Development Ltd | Construction | 2026 |
| Signaura Limited | Transport & logistics | 2025 |
| Silk Road Redux Limited | Wholesale & retail | 2025 |
| Silvary-Creating Memories Ltd | Professional & scientific | 2024 |
| Silver Service Carers Ltd | Other services | 2010 |
| Silver Street Investments Limited | Real estate | 2018 |
| Silver Tongued Films Limited | Information & communication | 2026 |
| Silverback Consultants Limited | Information & communication | 2018 |
| Silvercroft Housing Limited | Real estate | 2026 |
| Silverhighway Ltd | Information & communication | 2014 |
| Simbec Properties LLP | | 2010 |
| Sime & Sime Limited | Real estate | 2014 |
| Simes Engineering Services Limited | Professional & scientific | 2004 |
| Simmons Consulting Engineers Ltd | Construction | 2015 |
| Simon Blackburn Consultants Limited | Construction | 2025 |
| Simor Ltd | Professional & scientific | 2018 |
| Simor Residential Ltd | Real estate | 2026 |
| Simply Envelopes Limited | Professional & scientific | 2004 |
| Simply INK Limited | Wholesale & retail | 2007 |
| Simply Psychics Ltd | Other services | 2024 |
| Simply SAM Ltd | Other services | 2025 |
| Simplytech Communication Ltd | Wholesale & retail | 2014 |
| Sims Property Services Ltd | Households | 2025 |
| Sinclair Sandwich Thanet Limited | Households | 1985 |
| Sink OR Swim (Midlands) Ltd | Education | 2018 |
| Site FAB Limited | Construction | 2013 |
| Site Service Solutions (Triple.S) Ltd | Manufacturing | 2011 |
| SJC Joiners & Builders Limited | Construction | 2016 |
| SK Carpentry & Joinery Limited | Construction | 2010 |
| SKE Consulting Ltd. | Extraterritorial | 2006 |
| Skeavington Horseboxes Ltd | Wholesale & retail | 2022 |
| Sketchpro Ltd | Professional & scientific | 2025 |
| Skin Appeal Aesthetics Ltd | Other services | 2019 |
| Skins Sexual Health Limited | Manufacturing | 2016 |
| Skipit Limited | Water & waste | 2011 |
| SKR Competitions Ltd | Arts & recreation | 2026 |
| Skyhigh Studios Ltd | Information & communication | 2024 |
| Skyline and Stone Real Estate Limited | Real estate | 2025 |
| Skytech Wellness Alliance Ltd | Transport & logistics | 2023 |
| Slaney Kennels and Cattery Limited | Administrative & support | 2018 |
| Sleaford Cars Centre Ltd | Wholesale & retail | 2024 |
| Slice of Saturday Night Ltd | Arts & recreation | 2015 |
| Slide Wardrobes Direct Ltd | Manufacturing | 2010 |
| Slipshod Ltd | Arts & recreation | 2023 |
| Slmt Ltd | Wholesale & retail | 2025 |
| Sloganize Ltd | Extraterritorial | 2020 |
| SM Portfolio Ltd | Wholesale & retail | 2009 |
| SM Veterinary Services Limited | Professional & scientific | 2024 |
| Small Oak Furniture Warehouse Ltd | Manufacturing | 2026 |
| Smart & Secure Homes Ltd | Administrative & support | 2014 |
| Smart Choice Properties Limited | Real estate | 2020 |
| Smart Dreams Property Ltd | Construction | 2024 |
| Smart Modular Group Ltd | Manufacturing | 2018 |
| Smart Move (Newark) Limited | Real estate | 2013 |
| Smart Property Lettings and Developments Ltd | Real estate | 2019 |
| Smart Vw's Limited | Extraterritorial | 2011 |
| Smart Vw's Sales Limited | Wholesale & retail | 2014 |
| Smeatons Lakes Limited | Hospitality | 2002 |
| SMH Recycling Limited | Water & waste | 2018 |
| Smooth Nationwide Holdings Ltd | Financial services | 2023 |
| Smooth Property Services Nationwide Ltd | Real estate | 2022 |
| Smooth Virtual Services Ltd | Real estate | 2024 |