| Rightway (EOT) Limited | Financial services | 2021 |
| Rightway Limited | Wholesale & retail | 2002 |
| Ritchwood Supplies Ltd | Wholesale & retail | 2025 |
| Rivergate Limited | Construction | 2015 |
| RJ Future Ltd | Real estate | 2021 |
| RM Plumbing & GAS Ltd | Construction | 2019 |
| Rnjk Consulting Ltd | Professional & scientific | 2025 |
| Road Transport & Industrial Training Limited | Real estate | 1997 |
| ROB Mcnulty Limited | Professional & scientific | 2003 |
| Roberts Property Ltd | Real estate | 2016 |
| RON Welsh (North West) Limited | Professional & scientific | 2004 |
| Roots & Rebel Ltd | Other services | 2025 |
| Rovert Equipment Company Limited | Wholesale & retail | 2015 |
| Royle Rentals Ltd | Real estate | 2026 |
| RP Site Engineering Ltd | Construction | 2010 |
| Rtcp Estates Limited | Professional & scientific | 2025 |
| RTG Talent Holdings Limited | Financial services | 2025 |
| Ruengburee Ltd | Hospitality | 2018 |
| Russell Painting Holdings Limited | Professional & scientific | 2018 |
| Ruthjp Ltd | Health & social care | 2026 |
| RW Technical Holdings Ltd | Construction | 2025 |
| S D B Property Repairs Ltd | Construction | 2026 |
| S&R Jackson Consulting Ltd | Professional & scientific | 2021 |
| Sabercharge Limited | Professional & scientific | 2021 |
| Safa Structures Ltd | Professional & scientific | 2023 |
| Safe AS Houses NW Limited | Agriculture & fishing | 2005 |
| Sagesse Ltd | Professional & scientific | 2020 |
| Sajman Ltd | Hospitality | 2026 |
| SB Capital and Investments Limited | Financial services | 2022 |
| Scrubz Ltd | Wholesale & retail | 2025 |
| SDB Interiors Ltd | Wholesale & retail | 2025 |
| Secure Ground Solutions Ltd | Manufacturing | 2017 |
| Securehr Ltd | Administrative & support | 2025 |
| SEE Here Ltd | Health & social care | 2026 |
| Sefton Group Limited(The) | Real estate | 1965 |
| Sefton Land Limited | Real estate | 1979 |
| Sefton Securities Limited | Real estate | 1979 |
| Serpentine Management Company Limited | Real estate | 2018 |
| Sgbailey Automation Limited | Professional & scientific | 2017 |
| Shanderry Elevator & Escalator Consultants (UK) Ltd | Professional & scientific | 2017 |
| Sherlock Estate Management Limited | Households | 2022 |
| Shineuk Ltd | Other services | 2016 |
| Shop 4 Neston Community Interest Company | Wholesale & retail | 2020 |
| Shoretrench Ltd | Professional & scientific | 2020 |
| Simply Roofing North West Ltd | Construction | 2026 |
| Simply Roofing NW Ltd | Construction | 2020 |
| SJA Construction Ltd | Construction | 2012 |
| Skin Renew Aesthetics Ltd | Health & social care | 2019 |
| Skipper Films Limited | Information & communication | 2007 |
| Sksje Limited | Other services | 2022 |
| Skyemotion Ltd | Financial services | 2012 |
| Sleipnir Electronics Limited | Professional & scientific | 2017 |
| Slipstream Machines Limited | Professional & scientific | 2005 |
| Slothar Ltd | Information & communication | 2010 |
| SNJ Lamb Installations Ltd | Construction | 2021 |
| Snwkarate Ltd. | Arts & recreation | 2018 |
| Something About Maeve Ltd | Wholesale & retail | 2026 |
| Sonargaon Neston Ltd | Hospitality | 2023 |
| Sonberg Global Ltd | Wholesale & retail | 2022 |
| Souber Tools Limited | Manufacturing | 2003 |
| Space Panda Ltd | Professional & scientific | 2020 |
| Spectra International (UK) Limited | Wholesale & retail | 2012 |
| Spiga Consultancy Limited | Professional & scientific | 2023 |
| SRM Project Services Ltd | Professional & scientific | 2017 |
| ST John Interpreting Translating Consultancy Ltd | Professional & scientific | 2022 |
| Stanley Arms Anderton Ltd | Hospitality | 2018 |
| Starfield NW Ltd | Real estate | 2025 |
| Staywarm Insulating & Heating Engineers Limited | Construction | 1965 |
| Steadfast Mortgages Limited | Financial services | 2023 |
| Stephen Boyd Hairdressing Ltd | Other services | 2017 |
| Stewart Quality Services (SQS) Ltd | Professional & scientific | 2019 |
| Strength & Performance Fitness Ltd | Arts & recreation | 2025 |
| Subpad Homes Ltd | Construction | 2019 |
| SUE Parker-Tantush Consulting Ltd | Professional & scientific | 2022 |
| SUM Business Solutions Ltd | Professional & scientific | 2010 |
| Summer Pops Ltd | Arts & recreation | 2019 |
| Surmount Management Limited | Professional & scientific | 2026 |
| Sutton Smith Medical Limited | Health & social care | 2020 |
| Swallows Theatre CIC | Arts & recreation | 2025 |
| Swan House Studios Ltd | Information & communication | 2025 |
| Swan Medical Consulting Limited | Professional & scientific | 2023 |
| Swiftly Solved Health Ltd | Health & social care | 2025 |
| Switchgear Services & Solutions Limited | Manufacturing | 2008 |
| Symmetry Properties Limited | Real estate | 2019 |
| Syncedhub Ltd | Information & communication | 2024 |
| Tandy 13 Holdings Limited | Real estate | 2025 |
| Tasmin Berman EYE Care Limited | Health & social care | 2024 |
| Telecommunications Management (UK) Limited | Information & communication | 1998 |
| Tenbillion Ltd | Administrative & support | 2018 |
| Terra Luxe Studio Ltd | Other services | 2025 |
| Terrig Ltd | Information & communication | 2018 |
| THE Active Merchandising Company Limited | Professional & scientific | 1997 |
| THE Addresses Co Ltd | Real estate | 2021 |
| THE Anglo-Italian Trading Company Limited | Administrative & support | 2013 |
| THE Annuity Specialist Limited | Extraterritorial | 2011 |
| THE Bark Cart Ltd | Arts & recreation | 2025 |
| THE Bread Collective & Bake School Limited | Wholesale & retail | 2021 |
| THE Courtyard Willaston Management Company Limited | Households | 2003 |
| THE Entrepreneur Society Ltd | Administrative & support | 2023 |
| THE Fairy Glen Estate (Dwygyfylchi) Ltd | Real estate | 2000 |