| Spades Car Sale Ltd | Wholesale & retail | 2021 |
| Spain Building & Maintenance Limited | Construction | 2002 |
| Spark Impex Ltd | Wholesale & retail | 2021 |
| Sparkcrafters Advertisers Ltd | Professional & scientific | 2025 |
| Sparman Ltd | Wholesale & retail | 2020 |
| Specialist Mobility Limited | Wholesale & retail | 2010 |
| Spectre Property Management Ltd | Real estate | 2025 |
| Spectrum Properties Ltd | Real estate | 2014 |
| Speedy Haulage (NW) Ltd | Transport & logistics | 2024 |
| Speedy Salvage Ltd | Wholesale & retail | 2015 |
| Spice Garden BB Ltd | Hospitality | 2024 |
| Spingit Limited | Wholesale & retail | 2024 |
| Spire CS Limited | Construction | 2009 |
| Sportex Clothing Company Limited | Wholesale & retail | 2006 |
| Sportex Investments Ltd | Real estate | 2018 |
| Spotless Solutionz Ltd | Administrative & support | 2026 |
| Spring Gardens Management Company Limited | Real estate | 2023 |
| Spring Hill Motors Lancs Limited | Wholesale & retail | 2025 |
| Spring Motor Group Limited | Wholesale & retail | 2024 |
| Springfield Estates (NW) Ltd | Real estate | 2020 |
| SQT Consultancy Limited | Other services | 2017 |
| SR Desserts Ltd | Wholesale & retail | 2015 |
| Srellahi Ltd | Construction | 2024 |
| ST Thomas Close (Barrowford) Management Limited | Real estate | 2019 |
| Stacked Nelson Ltd | Hospitality | 2024 |
| Stafford Pubs Limited | Hospitality | 2026 |
| Stainthwaite Boarding Kennels Ltd | Agriculture & fishing | 2023 |
| Stainthwaite Grooming Ltd | Agriculture & fishing | 2025 |
| Standel Dawman Limited | Manufacturing | 2004 |
| Stanley White Properties Ltd | Real estate | 2024 |
| Stansfield Bros. Ltd | Administrative & support | 2007 |
| Star Learning Ltd | Education | 2023 |
| Star Marketing Solutions Ltd | Professional & scientific | 2020 |
| Star Plus Fashion Ltd | Wholesale & retail | 2019 |
| Starmart Convenience Limited | Wholesale & retail | 2022 |
| Steadplan Group Limited | Professional & scientific | 2015 |
| Steadplan Limited | Wholesale & retail | 2008 |
| Steadplan Properties Ltd | Real estate | 2002 |
| Steadplan Rental Limited | Administrative & support | 2009 |
| Steadplan Truck and Trailer Sales Ltd | Manufacturing | 2009 |
| Steele Greenwood Catering Limited | Hospitality | 2024 |
| Steele Greenwood Legal Services Limited | Professional & scientific | 2014 |
| Stellar Odyssey Holdings Limited | Real estate | 2025 |
| Steprack Ltd | Manufacturing | 2025 |
| Sterling Stuff UK Ltd | Wholesale & retail | 2026 |
| Steven Backhouse Group of Companies Limited(The) | Financial services | 1974 |
| Stinky Squirrel Home Fragrances Ltd | Manufacturing | 2025 |
| Stobbs Trade Limited | Other services | 2025 |
| Stop & Shop Premier Limited | Wholesale & retail | 2024 |
| Storage Haus Ltd | Transport & logistics | 2026 |
| STP Healthcare Ltd | Wholesale & retail | 2026 |
| Straight Line Engineering Limited | Manufacturing | 1981 |
| Straits Properties Ltd | Real estate | 2020 |
| Strategic Management Solutions Limited | Extraterritorial | 2010 |
| Strong Building Material Limited | Wholesale & retail | 2024 |
| Stuarts PUB Limited | Hospitality | 2017 |
| STUDIO-202 Ltd | Arts & recreation | 2021 |
| Stydd Gardens Management Limited | Hospitality | 2021 |
| Style and Elegance Limited | Wholesale & retail | 2026 |
| Stylish Homes (Nelson) Ltd | Construction | 2020 |
| Sugden Limited | Manufacturing | 1977 |
| Sumaira Retails Limited | Wholesale & retail | 2024 |
| Sumaira's Home Kitchen Indian and Pakistani Food Limited | Wholesale & retail | 2025 |
| Sumbal's Limited | Wholesale & retail | 2024 |
| Sunny Khan Studios Ltd | Information & communication | 2017 |
| Sunrise Software Solutions Limited | Information & communication | 2013 |
| Supamart UK Ltd | Wholesale & retail | 2015 |
| Super Barbers Limited | Other services | 2021 |
| Super Cutz Limited | Other services | 2025 |
| Super Lift Heavy Equipment Trading UK Ltd | Wholesale & retail | 2025 |
| Super Sofo Limited | Wholesale & retail | 2025 |
| Superior Graphics Ltd | Manufacturing | 2024 |
| Supply Sphere Ltd | Wholesale & retail | 2025 |
| Supreme Speedy Couriers Ltd | Transport & logistics | 2026 |
| Surdival Electrical Services Limited | Construction | 2015 |
| Sure Electrical Solutions Ltd | Construction | 2024 |
| Sure Frame (Northants) Limited | Other services | 2020 |
| Surety Plus Limited | Professional & scientific | 2025 |
| Surge Chain Limited | Professional & scientific | 2025 |
| Susma Limited | Hospitality | 2018 |
| Sustainability Events Ltd | Professional & scientific | 2024 |
| Swaledale A.T.V. Limited | Manufacturing | 2007 |
| Swalewell Limited | Extraterritorial | 2006 |
| Swan Specialist Limited | Other services | 2010 |
| Swan Windows (NW) Limited | Construction | 2007 |
| Sweet Chilli Production Ltd | Information & communication | 2023 |
| Sweeten UP Limited | Hospitality | 2025 |
| Swift Custom Packaging Ltd | Administrative & support | 2025 |
| Swiftcom IT Group Ltd | Information & communication | 1998 |
| Swiftedge Global Ltd | Wholesale & retail | 2025 |
| Swim Cellar Limited | Arts & recreation | 2022 |
| Swirlz Packaging Limited | Wholesale & retail | 2025 |
| Swiss Boom Ltd | Wholesale & retail | 2024 |
| SY Optical Limited | Health & social care | 2022 |
| Syed AB Ltd | Real estate | 2026 |
| Syed Shabee Haider Limited | Wholesale & retail | 2026 |
| SYK Management Limited | Real estate | 2020 |
| Sylqore Ltd | Wholesale & retail | 2026 |
| Synovus Ltd | Health & social care | 2019 |
| T & F Steel Designs Limited | Manufacturing | 2002 |