| Rs-A Superstore Limited | Wholesale & retail | 2019 |
| RSA Commercial Hire Ltd | Administrative & support | 2023 |
| Rsellahi Ltd | Construction | 2019 |
| RSS Shop Ltd | Wholesale & retail | 2021 |
| RTB Partnership Limited | Professional & scientific | 2013 |
| Rubble Ltd | Real estate | 2025 |
| Ruby and Molly Ltd | Wholesale & retail | 2009 |
| Ruhani Health Limited | Education | 2015 |
| Rupert Totti Limited | Extraterritorial | 2020 |
| Russell Bros (Property) Ltd | Real estate | 2015 |
| Russell Shaun Enterprises Limited | Arts & recreation | 2007 |
| Ruwa&Co Ltd | Wholesale & retail | 2026 |
| Rydal Crabtree Ltd | Real estate | 2022 |
| S & W Housing Limited | Construction | 2025 |
| S & W Luxury Travel Limited | Administrative & support | 2025 |
| S a Clothing (MCR) Ltd | Wholesale & retail | 2020 |
| S a Clothing Ltd | Wholesale & retail | 2022 |
| S C Hire Services Limited | Wholesale & retail | 2010 |
| S Mall NET PVT Limited | Wholesale & retail | 2008 |
| S O Nashville Burnley Ltd | Hospitality | 2024 |
| S&A Online Traders Ltd | Wholesale & retail | 2024 |
| S&G Assessments Ltd | Health & social care | 2024 |
| S&I Legal Ltd | Professional & scientific | 2025 |
| S&W Interiors Lancs Ltd | Wholesale & retail | 2025 |
| S&W Interiors Ltd | Wholesale & retail | 2024 |
| S.J. Hatfield & SON Limited | Wholesale & retail | 1999 |
| S4 Solutions Limited | Information & communication | 2000 |
| SA Autos Doncaster Limited | Wholesale & retail | 2026 |
| SA Decor Ltd | Construction | 2026 |
| SA Optom Ltd | Health & social care | 2023 |
| SA Properties Lancashire Ltd | Real estate | 2023 |
| Sabnaud Limited | Other services | 2020 |
| Sacm Ltd | Professional & scientific | 2026 |
| Sadie Nicholson PA Ltd | Administrative & support | 2016 |
| Saf's Hairdressing Beauty Studio & Accessories Ltd | Other services | 2024 |
| Safco Homes Ltd | Construction | 2022 |
| Safe Deposit Centre Nelson Limited | Transport & logistics | 2023 |
| Safepath Living Ltd | Health & social care | 2026 |
| Safewatch Security Limited | Administrative & support | 2025 |
| SAG Future Tech Ltd | Wholesale & retail | 2025 |
| Sail Crowd Ltd | Wholesale & retail | 2019 |
| Saji Motors Limited | Administrative & support | 2024 |
| Sal's Upholstery & Foam Limited | Wholesale & retail | 2025 |
| Salam Bedford CIC | Education | 2026 |
| Salt & Pepper Village Ltd | Hospitality | 2025 |
| Sama Consulting Ltd | Information & communication | 2019 |
| Sama Media Limited | Professional & scientific | 2024 |
| Samiual Home Care Limited | Health & social care | 2024 |
| Samosa Junction Catering Ltd | Wholesale & retail | 2019 |
| Samuel Peter Hair Limited | Other services | 2019 |
| Sanai S K Trader Limited | Wholesale & retail | 2024 |
| Sanas Bakes Ltd | Manufacturing | 2021 |
| Sandersons Dance & Fitness Centre Limited | Arts & recreation | 2002 |
| Sandman Holdings Ltd | Real estate | 2015 |
| Santos Oldham Ltd | Hospitality | 2024 |
| Sanus Ltd | Wholesale & retail | 2021 |
| Sapere CPA Ltd | Professional & scientific | 2026 |
| SAR Pharm Limited | Health & social care | 2022 |
| Sarah Carr Ltd | Health & social care | 2018 |
| Saram Speedex Ltd | Transport & logistics | 2012 |
| Sassy Housing Ltd | Real estate | 2025 |
| Satcam Security Limited | Administrative & support | 2022 |
| Savin Ltd | Manufacturing | 2024 |
| Savrange Limited | Other services | 2020 |
| Sayal Wazir Ltd | Wholesale & retail | 2024 |
| SB Process Limited | Professional & scientific | 2012 |
| SBJ Property Investments Ltd | Real estate | 2026 |
| Scalevia Systems Ltd | Professional & scientific | 2025 |
| Scenic Landscapes & Groundwork Limited | Other services | 2013 |
| Schema Prompts Ltd | Information & communication | 2026 |
| Scherzando Couriers Ltd | Transport & logistics | 2025 |
| School Brands Limited | Wholesale & retail | 2017 |
| Scopes Enterprise Ltd | Health & social care | 2015 |
| Scott Engineering Consultancy Ltd | Construction | 2022 |
| Scrap My Car Limited | Wholesale & retail | 2018 |
| Scruples Menswear Limited | Extraterritorial | 2020 |
| SCS Car Sales Ltd | Wholesale & retail | 2025 |
| SCS Spades Car Sales Limited | Wholesale & retail | 2024 |
| SD Pinnacle Limited | Administrative & support | 2016 |
| SE Autos Trading & Repairs Ltd | Wholesale & retail | 2026 |
| Sean Smith Enterprises Ltd | Extraterritorial | 2020 |
| Secret Sshhh Ltd | Other services | 2024 |
| Secure 100 Limited | Administrative & support | 2012 |
| Secure Line Solutions Ltd | Manufacturing | 2022 |
| Securis Ltd | Administrative & support | 2025 |
| Security Wise (N.W) Limited | Administrative & support | 2005 |
| Seithpharma Limited | Health & social care | 2025 |
| Seldon Wheels and Tyres Ltd | Wholesale & retail | 2026 |
| Select & Shop Ltd | Wholesale & retail | 2026 |
| Selected Cyber Limited | Construction | 2024 |
| Sellinghub Trading Ltd | Wholesale & retail | 2020 |
| Sensorially Ltd | Wholesale & retail | 2024 |
| Serban Adam and EVA Ltd | Transport & logistics | 2024 |
| Serene Square Ltd | Real estate | 2024 |
| Service Point 1 Limited | Wholesale & retail | 2014 |
| Service Support Group Ltd | Information & communication | 2026 |
| Setgate Limited | Real estate | 1987 |
| Seth ALI Properties Limited | Real estate | 2022 |
| Seth Associates Limited | Wholesale & retail | 2017 |
| Sett Properties Ltd | Real estate | 2022 |