| Sigma Astronautics Ltd | Professional & scientific | 2023 |
| Sinclair Plant Hire & Groundworks Ltd | Construction | 2021 |
| Sisu Sessions Ltd | Education | 2022 |
| SJC Joinery (Scot) Ltd | Construction | 2024 |
| SJG Sourcing Ltd | Real estate | 2025 |
| SJS Property Services Limited | Construction | 1999 |
| SJT Accounting Limited | Professional & scientific | 2010 |
| SK Scot Enterprises Ltd | Real estate | 2024 |
| Sk-Build Group Ltd | Construction | 2024 |
| Skmb Enterprise Ltd | Real estate | 2025 |
| SL33260 LP | | 2018 |
| Sleepy Slumber Limited | Wholesale & retail | 2025 |
| Slick Building Services Limited | Construction | 2024 |
| SM Taxi Services Limited | Extraterritorial | 2003 |
| Smeaton Park Consulting Limited | Professional & scientific | 2020 |
| Smeaton Park Ltd | Real estate | 2014 |
| Smith Design Engineering Ltd | Professional & scientific | 2021 |
| Snowdrop Services Scotland Limited | Administrative & support | 2011 |
| Social Ball Kids Ltd | Health & social care | 2014 |
| Sociotechnical Limited | Administrative & support | 2021 |
| Solar Kingdom Limited | Construction | 2009 |
| Solid Cars Ltd | Wholesale & retail | 2017 |
| Some Designer Ltd | Professional & scientific | 2020 |
| Sonic Airlines Ltd | Transport & logistics | 2026 |
| Soreon Ltd | Administrative & support | 2016 |
| Souness & Boyne Interior Contracts Ltd | Administrative & support | 2010 |
| Spaint Ltd | Construction | 2023 |
| Sparkling Horizon Ltd | Administrative & support | 2024 |
| SPG Capital Ltd | Real estate | 2025 |
| Splash Start Limited | Arts & recreation | 2012 |
| Sportsmanbarcw Limited | Hospitality | 2025 |
| Spotless Commercial Cleaning Limited | Administrative & support | 1996 |
| Spotlight Support C.I.C. | Health & social care | 2017 |
| SR Flooring Edinburgh Limited | Construction | 2016 |
| Stage Door Entertainment Ltd | Arts & recreation | 2023 |
| Staypress Ltd | Other services | 2025 |
| Stealth Systems Ltd | Information & communication | 2014 |
| Steve Reid Photography Ltd | Professional & scientific | 2024 |
| Stevenson Astrosat Ltd | Professional & scientific | 2021 |
| Stevenson Industries Limited | Financial services | 2021 |
| Strategic Consulting Limited | Information & communication | 2024 |
| Strathesk Resolutions Limited | Administrative & support | 2018 |
| Strawberry Hill Nurseries Limited | Health & social care | 2001 |
| Stuart Reid Plant Ltd | Construction | 2021 |
| Studio ESK Ltd | Other services | 2025 |
| Styl by M Ltd | Other services | 2022 |
| Sustainable Facilities Management Ltd | Administrative & support | 2020 |
| SWB Roofing Ltd | Construction | 2024 |
| Sweet Haven of Musselburgh Limited | Wholesale & retail | 2018 |
| Sweet Treat Musselburgh Ltd | Hospitality | 2021 |
| Swiftcoast Limited | Transport & logistics | 2002 |
| SY Mobile Welding Services Ltd | Construction | 2021 |
| Sygma Cadd Ltd | Professional & scientific | 2021 |
| Sygma Enterprises Ltd | Households | 2024 |
| T & a Taxis Limited | Extraterritorial | 2000 |
| T a Burke Limited | Real estate | 2018 |
| TAE a Moose Pest Control Services Limited | Administrative & support | 2017 |
| Take a Breath Physiotherapy Ltd | Other services | 2025 |
| Tallboy Services Ltd | Real estate | 2024 |
| Tartan Talks Limited | Administrative & support | 2024 |
| Taurus Joinery & Construction Ltd | Construction | 2024 |
| Taxi for Edinburgh Ltd. | Professional & scientific | 2012 |
| Taxone Accounting Ltd | Professional & scientific | 2024 |
| Taxone Consulting Ltd | Professional & scientific | 2020 |
| Tay&Ythan Ltd | Hospitality | 2026 |
| Taybridge Properties Ltd | Real estate | 2025 |
| Taylor Bain Furniture Ltd. | Manufacturing | 2014 |
| Taylor PS Ltd | Professional & scientific | 2022 |
| Tazzeo Enterprises Ltd | Wholesale & retail | 2017 |
| Tbci Limited | Other services | 2022 |
| Techwise Ltd | Wholesale & retail | 2026 |
| Teh-Node Ltd | Information & communication | 2010 |
| Tenroc Investments Ltd | Real estate | 2025 |
| Terrazzalakt Ltd | Manufacturing | 2026 |
| Tesla Electrical Solutions Ltd. | Construction | 2016 |
| TFV Limited | Public administration | 2021 |
| TG Cleaning Ltd | Administrative & support | 2024 |
| THE Andes Restaurant Ltd | Hospitality | 2021 |
| THE Brunstane Group Limited | Construction | 2018 |
| THE CAM HR Partnership Ltd | Professional & scientific | 2022 |
| THE Complete Building Service (Scotland) Ltd | Professional & scientific | 2018 |
| THE Devlin Group Limited | Health & social care | 2010 |
| THE Fencing Specialists Ltd | Construction | 2026 |
| THE Fitness Coach Chronicle Limited | Education | 2025 |
| THE Ghost Club Limited | Administrative & support | 2026 |
| THE Gym Unit Ltd | Arts & recreation | 2026 |
| THE Kilted Haggis Cafe Ltd | Hospitality | 2023 |
| THE KIT Company Scotland Limited | Construction | 2017 |
| THE Kuckoo Company Limited | Manufacturing | 2006 |
| THE Line Group Ltd | Professional & scientific | 2023 |
| THE Livingroom Church | Other services | 2013 |
| THE Musselburgh Golf Club Limited | Arts & recreation | 2014 |
| THE NU Movement Ltd | Wholesale & retail | 2025 |
| THE Nutcracker Christmas Company Ltd | Wholesale & retail | 2022 |
| THE Nutri Coaching Group Ltd | Health & social care | 2025 |
| THE Original Haggis Cigar Company Limited | Manufacturing | 2021 |
| THE Red Thred Ltd | Manufacturing | 2026 |
| THE Sassenachs Ceilidh Band Ltd | Arts & recreation | 2024 |
| THE Social Care Foundation Ltd | Health & social care | 2023 |
| THE Tartan Timber Co Limited | Wholesale & retail | 2024 |