| RR Delights Ltd | Wholesale & retail | 2018 |
| RRL Electrical Limited | Construction | 2023 |
| Rrr&M Limited | Wholesale & retail | 2024 |
| RS Southside Limited | Arts & recreation | 2024 |
| RSH Contracts Limited | Professional & scientific | 2020 |
| Ruby Nails Motherwell Limited | Other services | 2026 |
| Runaway Productions Limited | Information & communication | 2001 |
| Ruthvensmith Limited | Administrative & support | 2023 |
| Rutland Land Limited | Construction | 1987 |
| RW Inns Ltd | Hospitality | 2023 |
| RWG Cabling Ltd | Information & communication | 2024 |
| Rwhgv. Limited | Transport & logistics | 2018 |
| RWL Contracts Ltd | Construction | 2025 |
| RWO Solutions Ltd | Administrative & support | 2022 |
| Ryagrup Ltd | Construction | 2026 |
| S & S Holdings (Scotland) Limited | Professional & scientific | 2005 |
| S Bell Management Ltd | Professional & scientific | 2026 |
| S Carmichael Homes Ltd | Other services | 2014 |
| S Carmichael Properties Ltd | Other services | 2014 |
| S D Samson (Music) Ltd | Arts & recreation | 2013 |
| S P Roofing Ltd. | Construction | 2007 |
| S&C Training Ltd | Other services | 2015 |
| S&E Landscape Limited | Administrative & support | 2026 |
| S&E Landscaping and Construction Limited | Administrative & support | 2022 |
| S&Z Autos Ltd | Wholesale & retail | 2025 |
| S&Z Store Ltd | Wholesale & retail | 2017 |
| S. Latter Ltd. | Construction | 2006 |
| S.A.M City Holdings Limited | Construction | 2016 |
| S.A.M Property Development Ltd | Other services | 2017 |
| S1TEAM Ltd | Professional & scientific | 2025 |
| S2S Contractors Ltd | Construction | 2022 |
| SA Home Decor Ltd | Wholesale & retail | 2024 |
| SA. One Ltd | Wholesale & retail | 2019 |
| SAA Commercial Limited | Wholesale & retail | 2015 |
| Sabreline Golf Limited | Manufacturing | 2021 |
| Safe AS Houses Limited | Real estate | 2015 |
| Safe Mind Ltd | Construction | 2022 |
| Safeonetransport Ltd | Transport & logistics | 2026 |
| Safety 1ST MOT Centre Ltd. | Wholesale & retail | 2009 |
| Safeway Contracts Ltd | Construction | 2017 |
| Safeway Services Ltd | Construction | 2021 |
| Sage Garden Rooms Limited | Other services | 2024 |
| Saimex Limited | Wholesale & retail | 2025 |
| Salali Logstic Ltd | Transport & logistics | 2026 |
| Salogan Retail Ltd | Wholesale & retail | 2024 |
| Saltire Online Limited | Other services | 2014 |
| Salus Risk Consultancy Ltd | Professional & scientific | 2022 |
| Salvoscot Ltd | Education | 2022 |
| SAM Rendering Ltd | Construction | 2025 |
| Sami Development Limited | Real estate | 2023 |
| Sampann Ltd | Hospitality | 2024 |
| Samuel James Property Group Ltd | Real estate | 2016 |
| Sann Logistics Ltd | Transport & logistics | 2025 |
| Sap-Kreations Ltd | Manufacturing | 2008 |
| Sarajia Islamic Studies and Community Centre Ltd | Other services | 2022 |
| Sarazen Consulting Ltd | Professional & scientific | 2022 |
| Sarfraz Nawaz Siddique Limited | Information & communication | 2024 |
| SAS Container Storage Ltd | Transport & logistics | 2023 |
| SAS Tyres Ltd | Administrative & support | 2017 |
| SBA Consultants Ltd | Real estate | 2026 |
| SC Project Solutions Ltd | Professional & scientific | 2017 |
| Scafell Coaching Ltd | Education | 2023 |
| Scapa Cards and Gifts Limited | Wholesale & retail | 2009 |
| Schengenhubtravels.Co.Uk Limited | Administrative & support | 2025 |
| Sciento Technology Limited | Information & communication | 2022 |
| SCM Mortgage Ltd | Financial services | 2019 |
| SCM Research Ltd | Professional & scientific | 2023 |
| Sconz Limited | Wholesale & retail | 2002 |
| Scoozi R US Limited | Hospitality | 2012 |
| Scope Property & Development Services Limited | Real estate | 2021 |
| Scot Building Services Ltd | Construction | 2014 |
| Scot PAK Limited | Transport & logistics | 2025 |
| Scotcro (SAP) Ltd | Information & communication | 2020 |
| Scotech 1077 Limited | Energy | 2012 |
| Scotech Welding Supplies Limited | Other services | 1997 |
| Scotia Padel Ltd | Arts & recreation | 2026 |
| Scotitech Solutions Limited | Information & communication | 2024 |
| Scott Glen Limited | Construction | 2013 |
| Scott Mckenzie IFA Ltd | Financial services | 2022 |
| Scott Wyllie Ltd | Transport & logistics | 2025 |
| Scottish Bioenergy Cooperative Ventures Limited | Manufacturing | 2007 |
| Scottish Rowing | Arts & recreation | 2009 |
| Scottow Moor Solar Limited | Energy | 2014 |
| Scotvend Limited | Administrative & support | 2021 |
| Scphg Ltd | Mining & quarrying | 2025 |
| Scroma Properties Limited | Real estate | 2019 |
| Scylina Ltd | Wholesale & retail | 2024 |
| SDX Enterprises Ltd | Financial services | 2025 |
| Sdztos Ltd | Wholesale & retail | 2025 |
| Sector VI Ltd | Administrative & support | 2025 |
| Secuore Scotland Ltd | Professional & scientific | 2023 |
| Seedy Nuts Ltd | Wholesale & retail | 2025 |
| Select Vehicles Scotland Limited | Wholesale & retail | 2025 |
| Semantic Group Ltd | Information & communication | 2024 |
| Senga's Snacks Ltd | Hospitality | 2024 |
| Seriously Successful Events Limited | Arts & recreation | 2001 |
| Serlzo Technologies Ltd | Professional & scientific | 2025 |
| Sfaglobal Ltd | Professional & scientific | 2023 |
| Sfmt Properties Limited | Real estate | 2026 |
| SG Humanist Ltd | Other services | 2017 |