| Engineering and Validation Services Ltd | Professional & scientific | 2020 |
| Engrailed Cross Investments Limited | Real estate | 1972 |
| Entertain-In Hospitality Staffing Ltd | Administrative & support | 2024 |
| Entmorph Ltd | Information & communication | 2019 |
| Enventi Limited | Professional & scientific | 2010 |
| Environment Measures Ltd. | Professional & scientific | 2004 |
| EOC Solutions Limited | Education | 2015 |
| EOS Tech Services Limited | Professional & scientific | 2025 |
| Epoch Investments Limited | Professional & scientific | 2014 |
| Eppl (Morpeth) Limited | Construction | 2016 |
| ERA Property Ventures Ltd | Real estate | 2022 |
| ERH Cleaning Services Ltd | Administrative & support | 2021 |
| ERH Machining Ltd | Professional & scientific | 2024 |
| Eshott Airfield Limited | Arts & recreation | 1993 |
| Eshott Shared Services Limited | Households | 2011 |
| Eshott South Farm Limited | Agriculture & fishing | 1995 |
| Ethos Supply Company Ltd | Wholesale & retail | 2023 |
| Ettore Speedworks Ltd | Wholesale & retail | 2025 |
| Euro Pizza Amble Ltd | Hospitality | 2022 |
| EVA Developments Ltd | Real estate | 2013 |
| Evrutherford Ltd | Administrative & support | 2022 |
| EWM Hightec Welding UK Limited | Wholesale & retail | 2008 |
| EX Lighting Limited | Manufacturing | 2019 |
| Exceling Consultancy Ltd. | Education | 2016 |
| Executype PA Limited | Professional & scientific | 2014 |
| Experience Factory Limited | Arts & recreation | 2021 |
| Experience Innovation Limited | Information & communication | 2020 |
| Exstopay Limited | Information & communication | 2015 |
| Extra Care Pet Grooming Ltd | Professional & scientific | 2020 |
| Faction North Ltd | Information & communication | 1998 |
| Fade N Freak Barber (NE) Ltd | Other services | 2026 |
| Fancy Sportswear Ltd | Wholesale & retail | 2024 |
| Farm Matters Ltd | Information & communication | 2014 |
| Fazuba Limited | Construction | 2018 |
| FC Blyth Limited | Arts & recreation | 2025 |
| Feac Ltd | Wholesale & retail | 2024 |
| Feature Creep Films Ltd | Information & communication | 2017 |
| Felton and Thirston Press CIC | Information & communication | 2026 |
| Felton Back Burn Bridge Company Limited | Construction | 2014 |
| Felton CAN - Climate and Nature Community Interest Company | Education | 2021 |
| Felton Property and Investments Limited | Real estate | 2002 |
| Fenwick & Rowell Ltd | Real estate | 2022 |
| Ferndene Cattery Limited | Other services | 2012 |
| Field Equip Ltd | Manufacturing | 2026 |
| Field Head Farm Management Company Limited | Real estate | 2004 |
| Fifi Aviation Limited | Administrative & support | 2020 |
| Fika Morpeth Limited | Wholesale & retail | 2025 |
| Filetrade Limited | Construction | 1998 |
| Financial Consultants NE Limited | Financial services | 2019 |
| Finishing Touches (Newcastle) Ltd | Wholesale & retail | 2005 |
| Finpact Community Interest Company | Information & communication | 2023 |
| Fisk Consulting Ltd | Information & communication | 2012 |
| Fit-Check Seven Ltd | Wholesale & retail | 2024 |
| FJS Energy Ltd | Administrative & support | 2025 |
| Flagmill Limited | Real estate | 1991 |
| Flatford Properties Limited | Real estate | 2024 |
| Fleet Auto Solutions Terminal Limited | Transport & logistics | 2021 |
| Floki Health Limited | Information & communication | 2017 |
| Florrie Jims Limited | Wholesale & retail | 2025 |
| Flow in Felton CIC | Other services | 2024 |
| Fluent Consulting Limited | Professional & scientific | 2006 |
| Flynn Wind Limited | Construction | 2023 |
| Footprints on the Moon (Family Centres) Limited | Arts & recreation | 2014 |
| Formation Education Ltd | Education | 2025 |
| Forster Plumbing Services Ltd | Construction | 2024 |
| Fort Energy Ltd | Professional & scientific | 2022 |
| Fotospin Limited | Professional & scientific | 2006 |
| Four Paws Hydrotherapy Limited | Professional & scientific | 2008 |
| FR Beaumont Ltd | Health & social care | 2025 |
| FR Detailing Ltd | Manufacturing | 2024 |
| Fram Park Ltd | Hospitality | 2021 |
| Frame Kirkland Ltd. | Professional & scientific | 2014 |
| Framnews Ltd | Information & communication | 2011 |
| Franklyn Blake Limited | Administrative & support | 2021 |
| Franklyn Blake Recruitment Limited | Administrative & support | 2021 |
| Fraser Cope Consulting Limited | Construction | 2024 |
| Front Street Tynemouth Limited | Extraterritorial | 2008 |
| Froyou Ltd | Hospitality | 2011 |
| Full Udder Limited | Health & social care | 2024 |
| Future Energy Engineering Ltd | Professional & scientific | 2011 |
| G & S Investment & Mortgages Limited | Financial services | 2009 |
| G a Evans Roofing Contractors Limited | Construction | 2000 |
| G a Smith Limited | Construction | 2007 |
| G Bowman Builders Limited | Construction | 2011 |
| G Dickinson Limited | Professional & scientific | 2010 |
| G R Connections Ltd | Manufacturing | 2015 |
| G T O'Kane Harvesting Ltd | Agriculture & fishing | 2012 |
| G Youll & SON Fencing Ltd | Construction | 2017 |
| G&H Properties Limited | Administrative & support | 1994 |
| G.M.C. Plumbing & Heating Services Ltd | Construction | 2012 |
| G.V. Engineering Limited | Manufacturing | 2000 |
| Gables Medical (Offender Health) Ltd | Health & social care | 2012 |
| Gadget Traders Ltd | Other services | 2025 |
| Gamerz Parties Ltd | Arts & recreation | 2025 |
| Gamma Umbra Limited | Energy | 2020 |
| Gary Wilson Limited | Construction | 2016 |
| Gastech-Ne Ltd | Education | 2012 |
| Gateway Business Services Limited | Professional & scientific | 2012 |
| Gateway Lighting Consultancy Ltd | Construction | 2022 |
| GAZ the GAS MAN Ltd | Construction | 2024 |