| Deucher Properties Ltd | Real estate | 2025 |
| Develop and LET Ltd | Construction | 2024 |
| Diamond Mobile Phones Ltd | Wholesale & retail | 2018 |
| Diamond Nails and Spa KT Ltd | Other services | 2024 |
| Dickinson & Reay Leisure Ltd | Other services | 2018 |
| Digitalferret Limited | Manufacturing | 2012 |
| Direct Research Europe Limited | Professional & scientific | 1999 |
| Distributed Systems Professional Services Limited | Information & communication | 1997 |
| Divas Parties Ltd | Other services | 2025 |
| DJM Energy Assessments Ltd | Professional & scientific | 2025 |
| Djroffshoreservices Limited | Professional & scientific | 2025 |
| DKC Associates Limited | Administrative & support | 2016 |
| Dkcs Limited | Construction | 1996 |
| Dlamont Consulting Limited | Information & communication | 2026 |
| DLM Legal Limited | Professional & scientific | 2018 |
| DM Veterinary Ltd | Professional & scientific | 2021 |
| DMR Leisure Ltd | Hospitality | 2021 |
| Dockstr Ltd | Wholesale & retail | 2018 |
| Dodds Project Group Ltd | Construction | 2023 |
| Donkey Meadows Campsite Morpeth Ltd | Hospitality | 2025 |
| Door Support (North East) Ltd | Administrative & support | 2008 |
| Doorforce North East Ltd | Construction | 2025 |
| Doors R US ( NE ) Ltd | Construction | 2024 |
| Dormant Legal Company Limited | Professional & scientific | 2021 |
| Dou-H @ Home Ltd | Hospitality | 2021 |
| Dovecote Farm Management Company Limited | Households | 2001 |
| Dovecote Street Arts CIC | Administrative & support | 2024 |
| Down to Earth Electrical Contractors Limited | Construction | 2026 |
| DR Bolt Tech Ltd | Professional & scientific | 2022 |
| Driveway Landscaping Solutions Ltd | Administrative & support | 2024 |
| Druridge Estate Management Company Limited | Administrative & support | 1997 |
| DS Aluminium Solutions Ltd | Administrative & support | 2016 |
| DS International Engineering Consultants Ltd | Professional & scientific | 2012 |
| DSB Commercials Ltd | Wholesale & retail | 2024 |
| DTM Express (North East) Ltd | Transport & logistics | 2022 |
| Duncan and Kirsty Ltd | Hospitality | 2021 |
| Dunnit Solutions Ltd | Information & communication | 2017 |
| DW Health Ltd | Wholesale & retail | 2025 |
| DX NET Solutions Limited | Information & communication | 2011 |
| Dylan Lowes Ltd | Construction | 2025 |
| Dynamic Precision Engineering Ltd | Professional & scientific | 2021 |
| E & a Offshore Services Limited | Professional & scientific | 2024 |
| E a Property Services Ltd | Real estate | 2026 |
| E Astley Limited | Wholesale & retail | 2023 |
| E C Groundworks Ltd | Construction | 2010 |
| E Four Limited | Real estate | 2005 |
| E W Residential Properties Limited | Real estate | 2016 |
| EAR WAX in EAR WAX OUT Ltd | Health & social care | 2025 |
| EAR WAX Removal Northumberland Limited | Health & social care | 2025 |
| Earsdon Professional Services Ltd | Professional & scientific | 2018 |
| Earthworks Landscape Architecture Ltd | Professional & scientific | 2023 |
| East Farm 2024 Ltd | Construction | 2023 |
| East Morpeth Farmers Limited | Other services | 1987 |
| East Shield Hill Farm (Management) Limited | Households | 1997 |
| East Thirston Farm Management Company Limited | Households | 2012 |
| East Thornton Equestrian Ltd | Arts & recreation | 2018 |
| East Wingates Holdings Limited | Agriculture & fishing | 2022 |
| Eastfield Estate Home Owners Limited | Health & social care | 2014 |
| Eaves Housing Ltd | Real estate | 2021 |
| ECE Coaching Ltd | Education | 2023 |
| ECE Horse Trading Ltd | Wholesale & retail | 2023 |
| ECE Livery Ltd | Agriculture & fishing | 2023 |
| ECG Civils Ltd | Administrative & support | 2021 |
| Eclipse Accountants Ltd | Professional & scientific | 2012 |
| Eclipse Training Associates Ltd | Education | 2012 |
| Econofreeze (Morpeth) Limited | Wholesale & retail | 1972 |
| Econofreeze Limited | | 1970 |
| Ecosafemed NE Ltd | Mining & quarrying | 2023 |
| Edinburgh Rifles and Sporting Goods (UK) Limited | Wholesale & retail | 2016 |
| Edson Electronics Limited | Manufacturing | 1989 |
| Edward Braithwaite Holdings Limited | Financial services | 2019 |
| Edynamix Global Ltd | Information & communication | 2014 |
| Edynamix UK Ltd | Information & communication | 2014 |
| EFG Couriers Ltd | Transport & logistics | 2025 |
| EGS Group Ltd | Agriculture & fishing | 2024 |
| EHU Power Ltd | Construction | 2021 |
| Eightyseven Business Solutions Ltd | Information & communication | 2018 |
| El-Hoddo Coffee Limited | Wholesale & retail | 2020 |
| Elabri Consultants Ltd | Construction | 2026 |
| Elastomer Solutions (UK) Ltd | Information & communication | 2012 |
| Elements Rothbury | Arts & recreation | 2015 |
| Elise Properties Limited | Real estate | 2019 |
| Elizabeth Connor Limited | Administrative & support | 2014 |
| Elizabeth Humphreys Homes Limited | Real estate | 2018 |
| Elizabeth Humphreys Properties Limited | Real estate | 2021 |
| Ellie's Beauty Parlour Ltd | Other services | 2024 |
| Ellington Social Welfare Centre Social Club Limited | Hospitality | 2000 |
| Elliott & Stone Limited | Arts & recreation | 2006 |
| Elliott Book-Keeping and Accountancy Service Ltd | Professional & scientific | 2020 |
| Elpha Lodge | | 1986 |
| Elsabenedict Limited | Information & communication | 2024 |
| Elvet Developments Ltd | Construction | 2015 |
| Emblematic (NE) Limited | Manufacturing | 2026 |
| Emergency Straps Limited | Manufacturing | 2017 |
| Emily Elizabeth Hilton Limited | Extraterritorial | 2025 |
| Emma Bunting Ltd | Wholesale & retail | 2023 |
| Emma Gibson Acupuncture Ltd | Health & social care | 2022 |
| Emmaus North East Property Holdings Ltd | Households | 2024 |
| Empor Limited | Manufacturing | 2006 |
| Energy Spec Ltd. | Professional & scientific | 2024 |