| Solarism Limited | Administrative & support | 2026 |
| Solo Engineering Products Ltd | Wholesale & retail | 2014 |
| Solutions Electrical Maintenance Limited | Manufacturing | 2012 |
| Sorodo Limited | Financial services | 2012 |
| Soulcraft Studios Ltd | Professional & scientific | 2024 |
| Source 2 Supply Limited | Wholesale & retail | 2005 |
| Southam Selections Limited | Administrative & support | 2025 |
| Sovo Trading Limited | Extraterritorial | 2020 |
| Specialist Health Care Training Ltd | Education | 2024 |
| Spectrum Aesthetics Ltd | Other services | 2023 |
| Speeds Healthcare Group Ltd | Wholesale & retail | 2015 |
| Speeds Ophthalmology Pharmacy Services Ltd | Extraterritorial | 2022 |
| Speeds Pharmacy Limited | Wholesale & retail | 2002 |
| Speedwell Projects Ltd | Other services | 2017 |
| Speight Wealth Management Limited | Financial services | 2018 |
| Spice Club Ltd | Hospitality | 2025 |
| Spirit of 58 Limited | Wholesale & retail | 2018 |
| Sposd Ltd | Financial services | 2022 |
| Sprint Fastening Systems Limited | Manufacturing | 2002 |
| Spruce Farm Ltd | Agriculture & fishing | 2019 |
| Square 2 Automotive Ltd | Wholesale & retail | 2023 |
| Ssas Properties Ltd | Real estate | 2020 |
| SSC Developments Ltd | Real estate | 2018 |
| ST. Mary's Mews Limited | Households | 1989 |
| Staff 86 Limited | Administrative & support | 2021 |
| Staxx Group Ltd | Wholesale & retail | 2022 |
| Stenhouse Developments Limited | Construction | 2018 |
| Steve Bracey Aviation Training Limited | Other services | 2002 |
| Stilgoe Properties Ltd | Other services | 2011 |
| Stone & Furrow Ltd | Real estate | 2025 |
| Stonehenge Steel UK Limited | Wholesale & retail | 2021 |
| Stop Gambling Ltd | Extraterritorial | 2023 |
| Storemy.Com Limited | Manufacturing | 2016 |
| Stories WE Hold Near Ltd | Health & social care | 2026 |
| Stork Software Limited | Information & communication | 1997 |
| Sullivan & SON Properties Ltd | Households | 2021 |
| Summit Performance Limited | Professional & scientific | 2025 |
| Summit to Sea Conversions Limited | Wholesale & retail | 2016 |
| Summits Capital Limited | Information & communication | 2025 |
| Sunday Gathering CIC | Wholesale & retail | 2024 |
| Sunnysite Property Management Limited | Households | 1999 |
| Sunray Day Care Nursery Limited | Health & social care | 2012 |
| SUP Lass Paddle Adventures Ltd | Arts & recreation | 2023 |
| Sustainable Fibre Alliance | Agriculture & fishing | 2015 |
| Suzy Counselling Services Ltd | Health & social care | 2026 |
| SW Digital Consultancy Ltd | Other services | 2023 |
| Swain Hennessey Estates Limited | Real estate | 2024 |
| Switch Ecology Ltd | Professional & scientific | 2023 |
| Swsinstallation Ltd | Construction | 2022 |
| Syncsoft Ltd | Information & communication | 2025 |
| Synergy Denture Clinic Ltd | Health & social care | 2020 |
| Synthite (Mold) Limited | Manufacturing | 2020 |
| Synthite Limited | Manufacturing | 1920 |
| Syrior CYF | Energy | 2016 |
| System Electrical Ltd | Construction | 2003 |
| T. O. Edwards Limited | Wholesale & retail | 2026 |
| T.R.E. Developments Limited | Real estate | 2000 |
| T.S.P.F Ltd | Agriculture & fishing | 2025 |
| T.W.Jones Ltd | Manufacturing | 2021 |
| T500 Properties Limited | Real estate | 2006 |
| Tailormade Celebrations Limited | Extraterritorial | 2015 |
| TCC Global Limited | Information & communication | 1996 |
| TCJ Inspections Ltd | Financial services | 2024 |
| Teacymru Limited | Wholesale & retail | 2018 |
| Tecartz Limited | Information & communication | 2021 |
| Tech 51 Mold Ltd | Wholesale & retail | 2018 |
| Ten-Percent.Co.Uk Limited | Administrative & support | 2000 |
| Tesni Properties Limited | Construction | 2006 |
| Tessellate IT Ltd | Information & communication | 2021 |
| TH HV Engineering Ltd | Professional & scientific | 2024 |
| THE 1810 Company Limited | Wholesale & retail | 2009 |
| THE Abbeyfield Cymru Society Limited | Other services | 2012 |
| THE Big Property Expert Wrexham Ltd | Real estate | 2017 |
| THE Busman Transport Consultancy Limited | Professional & scientific | 2018 |
| THE Canvas Tent Company Ltd | Administrative & support | 2018 |
| THE Chris Hogan C.I.C. | Education | 2025 |
| THE Coach House Penyffordd Limited | Hospitality | 2021 |
| THE Cockle Shell Ltd | Hospitality | 2020 |
| THE Content HUT Ltd | Information & communication | 2018 |
| THE Croft (Buckley) Management Company Limited | Households | 2023 |
| THE Cross Foxes Nannerch Limited | Hospitality | 2024 |
| THE Emigration Group Limited | Professional & scientific | 1995 |
| THE Flame Group Limited | Financial services | 2014 |
| THE Flooring and Restoration Company Limited | Construction | 2025 |
| THE Gallery Barbershop Ltd | Other services | 2022 |
| THE Groomery Dog Spa Limited | Other services | 2025 |
| THE Guild of Ghost Hunters Limited | Administrative & support | 2017 |
| THE Handle Factory Ltd | Manufacturing | 2019 |
| THE Hera Project CIC | Education | 2025 |
| THE Heywood Society Limited | Arts & recreation | 2002 |
| THE Hive Collaborative Ltd | Professional & scientific | 2021 |
| THE Hustle HQ Limited | Information & communication | 2023 |
| THE Installation Exchange Ltd | Wholesale & retail | 2020 |
| THE Little Bitty Farm and Campsite Ltd | Agriculture & fishing | 2024 |
| THE Little Learning Company Limited | Education | 2021 |
| THE Lounge Aesthetics Limited | Other services | 2016 |
| THE Memory Season Ltd | Wholesale & retail | 2026 |
| THE Natural Winemakers Ltd | Wholesale & retail | 2016 |
| THE Opus Pocus Ltd | Information & communication | 2019 |
| THE Paddocks 1956 Limited | Extraterritorial | 2014 |