| Rovia Limited | Other services | 2008 |
| Rowena Homes Ltd | Real estate | 2026 |
| Rowlands Electrical Ltd | Construction | 2026 |
| Royd Tolkien Productions Ltd | Extraterritorial | 2023 |
| RPD Electrical Ltd | Construction | 2005 |
| Rscj Properties Ltd | Real estate | 2026 |
| RSG Compliance and Validation Ltd | Professional & scientific | 2018 |
| Rthj Limited | Professional & scientific | 2023 |
| Russell Quality Consulting Ltd | Information & communication | 2025 |
| Ruth Dive Coaching Limited | Other services | 2018 |
| RW Connect Ltd | Construction | 2019 |
| RX Education Limited | Extraterritorial | 2000 |
| RX Market Access Limited | Extraterritorial | 2000 |
| RX Values Group Limited | Administrative & support | 2000 |
| S & G Ales Limited | Hospitality | 2024 |
| S Bassett Conservatories Windows and Doors Ltd | Construction | 2017 |
| S Cartwright Limited | Professional & scientific | 2021 |
| S Distribution Limited | Extraterritorial | 2017 |
| S Hughes Building and Joinery Limited | Construction | 2025 |
| S Jones Business Solutions Limited | Information & communication | 2000 |
| S P Chudyk Driver Relief Ltd | Transport & logistics | 2019 |
| S R Kontrols Limited | Professional & scientific | 2024 |
| S&G Baines Limited | Information & communication | 2026 |
| S. a. Davies Sustainable Construction Ltd | Construction | 2008 |
| S.B.E. Quality Assurance Engineering Limited | | 1991 |
| S.Dixon Ltd | Hospitality | 2017 |
| S.O.E Brickwork Ltd | Construction | 2020 |
| S.P.O. Joinery Limited | Construction | 2018 |
| Safe Hands Homes Limited | Real estate | 2019 |
| Safeware Limited | Information & communication | 2015 |
| Safeware Quasar Limited | Information & communication | 2022 |
| Salisbury Estimates Limited | Construction | 2022 |
| Same BUT Different CIC | Arts & recreation | 2015 |
| Same BUT Different Creative Ltd | Professional & scientific | 2021 |
| Samling Creative Services Ltd | Professional & scientific | 2025 |
| Sandpit Orchard Ltd | Professional & scientific | 2020 |
| Sang LI Ltd | Hospitality | 2020 |
| Saul Consulting Engineers Limited | Construction | 2001 |
| Savage Future Livings Ltd | Real estate | 2026 |
| Savva's Property Limited | Real estate | 2015 |
| Sawsand UK Ltd | Manufacturing | 2023 |
| Saza Foods Limited | Hospitality | 2018 |
| Sbfi MB Group Ltd | Wholesale & retail | 2026 |
| Scalix Marketing Limited | Professional & scientific | 2025 |
| Scandiplay Ltd | Arts & recreation | 2021 |
| Schock UK Bidco Limited | Professional & scientific | 2021 |
| Scientific Medical Ltd | Professional & scientific | 2022 |
| Scottmonds Limited | Real estate | 2020 |
| SDH Associates Ltd | Administrative & support | 2021 |
| SDM Joinery Holdings Limited | Administrative & support | 2021 |
| SDM Joinery Specialists Limited | Construction | 2013 |
| Sea Park (Apart) Hotel Limited | Hospitality | 1979 |
| Sea Park Finance Limited | Financial services | 2006 |
| Seaspray Systems Limited | Professional & scientific | 2003 |
| Security House Limited | Real estate | 2026 |
| Securiweld Ltd. | Manufacturing | 2014 |
| Seiclo Clwyd Limited | Arts & recreation | 2023 |
| Sekond Homes Limited | Real estate | 2024 |
| Select Hair & Beauty (N.W.) Ltd | Other services | 2010 |
| Selectrical Ltd | Construction | 2015 |
| Sequoia Medical Communications Limited | Professional & scientific | 2006 |
| Serenova Engineering Ltd | Manufacturing | 2025 |
| Server Room Environments Ltd | Information & communication | 2019 |
| SF Freight Ltd | Transport & logistics | 2025 |
| SF Project & Technical Services Ltd | Construction | 2015 |
| SFA International CIC | Education | 2023 |
| Sffa Ltd | Professional & scientific | 2023 |
| Shan Eatery Limited | Hospitality | 2026 |
| Sheasby Trading Limited | Professional & scientific | 2022 |
| Sheppard Plant Hire Limited | Construction | 2012 |
| Sherborne Investments Ltd | Real estate | 2021 |
| Sherratt Grounds Care Ltd | Extraterritorial | 2022 |
| Sherratt Group Ltd | Administrative & support | 2005 |
| Sherratt Holdings (NW) Ltd | Real estate | 2023 |
| Sherratt Landscape Services Ltd | Extraterritorial | 2022 |
| Sherratt Tree Services Ltd | Extraterritorial | 2022 |
| Shinyme Ltd | Information & communication | 2025 |
| Shoo 570 Limited | Professional & scientific | 2012 |
| Shoo 786AA Limited | Manufacturing | 2005 |
| Shss Ltd | Transport & logistics | 2020 |
| Siberian Timber (U.K.) Limited | Agriculture & fishing | 2002 |
| Signature TAN Ltd | Wholesale & retail | 2024 |
| Silmar Makers Ltd | Manufacturing | 2025 |
| SIM Group T/A Indian Lounge Ltd | Wholesale & retail | 2025 |
| Simply Green Lawns Limited | Other services | 2006 |
| Sion Williams Contracting Services Limited | Other services | 2015 |
| SK17 Properties Limited | Real estate | 2020 |
| SKH Holdings Ltd | Manufacturing | 2021 |
| Skol Properties Ltd | Real estate | 2025 |
| Skye Marquees Limited | Administrative & support | 2009 |
| Sliding FOX Solutions Limited | Information & communication | 2013 |
| SM Autos Mold Limited | Wholesale & retail | 2026 |
| Smith Family Opticians Limited | Wholesale & retail | 2004 |
| Sniff and Snails Limited | Education | 2020 |
| SNJ Consult Ltd | Construction | 2025 |
| Snowdonia Renewables Ltd | Wholesale & retail | 2022 |
| Sojourn Travel Ltd | Administrative & support | 2024 |
| Solace Development Limited | Information & communication | 2025 |
| Solar 2 Holdings LLP | | 2021 |
| Solar 2 Limited | Energy | 2019 |