| Sandalphon Arts Ltd | Arts & recreation | 2022 |
| Sangla Capital Limited | Wholesale & retail | 2025 |
| Sapient Consulting Ltd | Professional & scientific | 2019 |
| Saragaglia Couture Ltd | Arts & recreation | 2014 |
| Sarah & Co UK Ltd | Administrative & support | 2019 |
| Sarahzaaraz ( Bridal ) Limited | Wholesale & retail | 2018 |
| Sarason Business Ltd | Professional & scientific | 2012 |
| Sardor Promotion Limited | Transport & logistics | 2017 |
| Sareli Events Limited | Hospitality | 2020 |
| Saric Ltd | Manufacturing | 2020 |
| SAS Entertainment Ltd | Other services | 2014 |
| Sash Investments Limited | Real estate | 2022 |
| Sassi Renovations Ltd | Construction | 2025 |
| Sassy & Shasha Braids Lounge Limited | Other services | 2025 |
| Sathish Construction Limited | Construction | 2025 |
| SAU Construction Ltd | Construction | 2025 |
| Saucy BOY Sauces Ltd | Manufacturing | 2025 |
| SAV Properties Limited | Real estate | 2019 |
| SAV Stays Ltd | Real estate | 2023 |
| Savannah Technology Ltd | Manufacturing | 2024 |
| Savours London Ltd | Hospitality | 2025 |
| Sawi Ltd | Wholesale & retail | 2025 |
| Saxon Square Homes Limited | Real estate | 2022 |
| Sayez Autos Panel Limited | Wholesale & retail | 2021 |
| SAZ Removals and Storage Ltd | Transport & logistics | 2022 |
| SB Capital Investments Ltd | Financial services | 2020 |
| SB Hairandbeauty Ltd | Other services | 2025 |
| SB Ideal Properties Ltd | Real estate | 2023 |
| SB Tea Co Limited | Wholesale & retail | 2025 |
| Sburlis Limited | Transport & logistics | 2018 |
| Scarlet Besos Ltd | Wholesale & retail | 2023 |
| Scarlet Larkspur Ltd | Wholesale & retail | 2023 |
| SCB Finance Ltd | Professional & scientific | 2022 |
| Scepter Investments Limited | Real estate | 2005 |
| Schreckenberg Production Ltd | Information & communication | 2026 |
| Scil II (Topco) Limited | Financial services | 2021 |
| Scopus Journal Publication Ltd | Information & communication | 2026 |
| Scorpent Ltd | Construction | 2015 |
| Scott and Reids Property Ltd | Real estate | 2024 |
| Scott Marshall Associates Ltd | Construction | 2020 |
| Scpdirect Limited | Health & social care | 2010 |
| Sculpt Investments Limited | Real estate | 2018 |
| Sculptured Ltd | Education | 2012 |
| Scuro Workshop Limited | Manufacturing | 2016 |
| SDM Care Services Limited | Health & social care | 2025 |
| SDM Pipework & Construction Ltd | Construction | 2014 |
| SE Gardeners Ltd | Administrative & support | 2024 |
| Searchwell Properties Ltd | Real estate | 2020 |
| Second Culture Ltd | Manufacturing | 2025 |
| Seetaagenga Ltd | Real estate | 2025 |
| Seicom Ltd | Information & communication | 2013 |
| Seido Juku Limited | Health & social care | 2008 |
| Sel's Aesthetic Consulting Limited | Wholesale & retail | 2023 |
| Select Asset Management Limited | Construction | 2007 |
| Selected Hot Food Ltd | Hospitality | 2017 |
| Self Made Style 13 Limited | Information & communication | 2017 |
| Seliray Limited | Real estate | 2017 |
| Seltrix Ltd | Wholesale & retail | 2026 |
| Selva Builders Ltd | Construction | 2024 |
| Semak-Cat Ltd | Real estate | 2020 |
| Semper Strenvus Psychology Services Limited | Health & social care | 2016 |
| SEN Travel Services Limited | Transport & logistics | 2025 |
| Sencore Ltd | Wholesale & retail | 2020 |
| Sentinel Omni Services Limited | Construction | 2026 |
| Senxpress Ltd | Education | 2025 |
| Seoul Station Limited | Hospitality | 2025 |
| Serene Care Recruitment Limited | Administrative & support | 2023 |
| Serenic Medical Ltd | Health & social care | 2021 |
| Serenitys Stays Ltd | Extraterritorial | 2024 |
| Service Construction Limited | Construction | 2021 |
| Servix Security FM Ltd | Administrative & support | 2025 |
| Sesly Limited | Information & communication | 2026 |
| SET Stage and Site Crew Ltd | Construction | 2025 |
| Seymour Plastics Limited | Extraterritorial | 1962 |
| Sezzel Smart Trade Ltd | Construction | 2022 |
| SF Accountant Limited | Professional & scientific | 2014 |
| SF Asset Management Limited | Professional & scientific | 2025 |
| SF Ecom Venture Limited | Wholesale & retail | 2026 |
| SFX Studios Ltd | Information & communication | 2024 |
| SGM Contracts Limited | Construction | 2026 |
| SGS 85 Limited | Construction | 2017 |
| SH Haven Nest Ltd | Real estate | 2026 |
| Shaa Ltd | Wholesale & retail | 2025 |
| Shad Thames Cleaning Services Limited | Administrative & support | 2003 |
| Shad Thames Housekeeping Ltd | Administrative & support | 2023 |
| Shadowfax Property Limited | Real estate | 2019 |
| Shah UK Courier Ltd | Transport & logistics | 2021 |
| Shahrome Ltd | Wholesale & retail | 2025 |
| Shak Logistics Ltd | Transport & logistics | 2026 |
| Shakes and Gelato Limited | Hospitality | 2018 |
| Shantha Estate Limited | Real estate | 2017 |
| Shanthi Property Services Ltd | Real estate | 2019 |
| Shapers Developments Ltd | Construction | 2026 |
| Sharpdecorators Limited | Construction | 2013 |
| Sharshal Limited | Real estate | 2019 |
| Shasmiga Foods Ltd | Hospitality | 2018 |
| Shayaan Tech Ltd | Information & communication | 2024 |
| Shayah Cardiac Clinic Limited | Health & social care | 2025 |
| Sheffield Wire Rope Company Limited(The) | Extraterritorial | 1909 |
| Shelbrooke Autos Limited | Wholesale & retail | 2015 |