| Delaware Drive Industries Limited | | 1933 |
| Delcious Spice Kitchen Ltd | Hospitality | 2024 |
| Delders Dogs Ltd | Other services | 2022 |
| Delectable Limited | Professional & scientific | 2002 |
| Delhitadkauk Limited | Hospitality | 2024 |
| Deli 24 Limited | Manufacturing | 2009 |
| Deli Delivered Limited | Hospitality | 2007 |
| Deli Sandwiches Ltd | Hospitality | 2024 |
| Delicate Care Ltd. | Health & social care | 2023 |
| Delicate Skin Clinic Ltd | Other services | 2023 |
| Delicious Kebab & Peri Peri Ltd | Hospitality | 2024 |
| Delight Recruitment Solutions Ltd | Administrative & support | 2020 |
| Delightful K Kitchen Ltd | Hospitality | 2022 |
| Delinear Consulting Limited | Information & communication | 2007 |
| Delish Brands Limited | Financial services | 2024 |
| DELIVER8 Consulting Limited | Professional & scientific | 2018 |
| Deliverama UK Ltd | Transport & logistics | 2019 |
| Delivery & Installation Solutions Limited | Transport & logistics | 2009 |
| Delixia Limited | Manufacturing | 2005 |
| Della Street Ltd | Information & communication | 2025 |
| Della Street Productions Ltd | Information & communication | 2024 |
| Dellwell Residents Company Limited | Households | 1989 |
| Delta Capital Consulting Limited | Professional & scientific | 2018 |
| Delta-Innovation Limited | Agriculture & fishing | 2005 |
| Deltalogic Supply Limited | Wholesale & retail | 2025 |
| Deltar Home Company Ltd | Health & social care | 2024 |
| Deluxefix Ltd | Construction | 2025 |
| Delve Services Limited | Transport & logistics | 2015 |
| Dema Pure Limited | Wholesale & retail | 2022 |
| Demented Classics Ltd | Wholesale & retail | 2020 |
| Demesne Property Holdings Ltd | Real estate | 2020 |
| Demi Oguns UK Voluntary Support for Less Privileged Limited | Professional & scientific | 2013 |
| Demi Rose Productions Ltd | Other services | 2018 |
| Demian Transport Solutions Ltd | Transport & logistics | 2022 |
| Deming Forum UK Limited | Extraterritorial | 2000 |
| Demir Prime Services Ltd | Professional & scientific | 2024 |
| Demirius Ltd | Information & communication | 2025 |
| Demyers Davis Limited | Professional & scientific | 2017 |
| DEN Consultancy Ltd | Professional & scientific | 2013 |
| DEN of Gems Ltd | Wholesale & retail | 2024 |
| Denbigh Land (Bletchley) Limited | Real estate | 2004 |
| Denbigh Land (Watford) Limited | Real estate | 2010 |
| Denbigh Land Limited | Real estate | 2003 |
| Dencole Services Limited | Health & social care | 2018 |
| Denelli Group Ltd | Real estate | 2017 |
| Denisa Property Solutions Limited | Real estate | 2023 |
| Denise Smart Ltd | Administrative & support | 2005 |
| Denison Land & Planning Limited | Real estate | 1998 |
| Denizns Holdings Ltd | Financial services | 2024 |
| Denizns Ltd | Information & communication | 2017 |
| Denizns Recruitment Ltd | Administrative & support | 2024 |
| Dennis Carter (Global) Ltd | Transport & logistics | 2021 |
| Dental Centre Turkey UK Ltd | Administrative & support | 2015 |
| Dentistry by IBN Shams Limited | Health & social care | 2018 |
| DENTIX7 Ltd | Information & communication | 2026 |
| Denyer Hill Limited | Financial services | 2022 |
| DEO Bamboo Stiches Limited | Other services | 2018 |
| Deo-Accord Healthcare Ltd | Health & social care | 2013 |
| Deoleo Financial Limited | Financial services | 2019 |
| Deoleo UK Limited | Financial services | 2019 |
| Deovolante International Limited | Other services | 1982 |
| Department Music Limited | Information & communication | 2021 |
| Dependable Healthcare Support Ltd | Health & social care | 2017 |
| Depero Ltd. | Wholesale & retail | 2020 |
| Deployers Limited | Information & communication | 2024 |
| Deploysmart Limited | Information & communication | 2013 |
| Depot 13 Ltd | Administrative & support | 2021 |
| Depth of Light Ltd | Construction | 2022 |
| Derby Court (Liverpool) Ltd | Construction | 2019 |
| Derimel Limited | Health & social care | 2022 |
| Dermatox Skin Clinic Ltd | Health & social care | 2013 |
| Dermody Wall Bookkeeping Ltd | Professional & scientific | 2025 |
| Derry Investments Limited | Real estate | 2024 |
| Dersales Ltd | Wholesale & retail | 2025 |
| DES Consulting Limited | Information & communication | 2007 |
| DES FAY Building Services Limited | Construction | 2011 |
| Desert Dwell Digital Ltd | Information & communication | 2026 |
| Desertdwell Realty Ltd | Real estate | 2024 |
| Desi Creative Limited | Administrative & support | 2020 |
| Design Cuts Ltd | Wholesale & retail | 2013 |
| Design FR Living CIC | Health & social care | 2025 |
| Design Horizons Limited | Professional & scientific | 2008 |
| Design Link Lifestyle Limited | Wholesale & retail | 2009 |
| Design Lord Ltd | Professional & scientific | 2025 |
| Design Oasis Limited | Manufacturing | 2023 |
| Design Studio MXN Ltd | Wholesale & retail | 2019 |
| Design Tourist Ltd | Professional & scientific | 2018 |
| Design Zindagi Ltd | Information & communication | 2024 |
| Design-Smart Consulting Limited | Information & communication | 2014 |
| DESIGN2E Limited | Professional & scientific | 2011 |
| Designed by YOU Ltd | Real estate | 2020 |
| Designed Logically Limited | Information & communication | 2010 |
| Designer Ceramics Limited | Construction | 2021 |
| Designer Touch Stylists Ltd | Other services | 2020 |
| Designhaus.Eu Ltd | Manufacturing | 2008 |
| Designs on Learning Limited | Education | 2008 |
| Designs to Reality Limited | Construction | 1997 |
| Designzbyam Ltd | Wholesale & retail | 2026 |
| Desnyam Ltd | Professional & scientific | 2014 |
| Desouza Sports Management Limited | Arts & recreation | 2016 |