| Savanah Group Limited | Health & social care | 2024 |
| Save & Go Ltd | Wholesale & retail | 2025 |
| Saveasy Ltd. | Wholesale & retail | 2018 |
| Saved by Grace Ltd | Wholesale & retail | 2026 |
| Savee Healthcare Limited | Health & social care | 2016 |
| Saveyoursoul Ltd | Information & communication | 2020 |
| Saving Grace Limited | Professional & scientific | 2019 |
| Saving Sterling Services Limited | Information & communication | 2021 |
| Saving Time Ltd | Professional & scientific | 2026 |
| Saving Tomorrow CIC | Wholesale & retail | 2020 |
| Savn Limited | Real estate | 2025 |
| Savoi Limited | Hospitality | 2012 |
| Savvy Sourcing Ltd | Households | 2020 |
| Savwave Limited | Wholesale & retail | 2016 |
| Sawatch Limited | Information & communication | 2013 |
| Sawtad Technologies Inc, Ltd | Professional & scientific | 2022 |
| SAX Transport Limited | Transport & logistics | 2019 |
| Saxena Homes Ltd | Real estate | 2025 |
| Saxon Park Estate Management Company Limited | Real estate | 2022 |
| Saxon Place Management Company Limited | Households | 2001 |
| Saxon Willow Ltd | Financial services | 2024 |
| Saxonia Capital Limited | Real estate | 2022 |
| Sayed Investments Ltd | Real estate | 2021 |
| Sayer Haworth Housing Ltd | Real estate | 2022 |
| Sayi Consultancy Services Ltd | Information & communication | 2012 |
| Saymighty Ltd | Administrative & support | 2021 |
| SAZ Business Care Ltd | Professional & scientific | 2013 |
| SAZ Products Limited | Wholesale & retail | 2016 |
| Sazy Enterprises Ltd | Administrative & support | 2025 |
| SB and M Services Ltd | Information & communication | 2012 |
| SB Car Services Ltd | Other services | 2019 |
| SB Contracting Ltd | Manufacturing | 2024 |
| SB Digital Media Ltd | Professional & scientific | 2012 |
| SB Fire Ltd | Administrative & support | 2024 |
| SB Media Group EBT Trustees Limited | Administrative & support | 2025 |
| SB Media Group Limited | Professional & scientific | 2016 |
| SB Media Group Trustees Limited | Administrative & support | 2019 |
| SB7 Mobile Ltd | Information & communication | 2007 |
| SBC Electrical Contractors Limited | Construction | 2006 |
| SBD Automotive Holdings Limited | Financial services | 2021 |
| SBD Automotive Ltd | Administrative & support | 1997 |
| Sbdas IT Consultancy Limited | Extraterritorial | 2015 |
| Sbdas Properties Limited | Real estate | 2021 |
| SBF Eco Ltd | Wholesale & retail | 2025 |
| SBH Services MK Limited | Wholesale & retail | 2011 |
| SBH Spice HUT Ltd | Hospitality | 2019 |
| SBH Talent Management Ltd | Administrative & support | 2022 |
| Sbhurtun Ltd | Professional & scientific | 2022 |
| Sbln Property Limited | Real estate | 2025 |
| SBP Property Limited | Real estate | 2025 |
| SBR Investment Properties Limited | Real estate | 2022 |
| SC Costrans SRL Limited | Transport & logistics | 2018 |
| SC Insights International Ltd | Information & communication | 2022 |
| SC Planters Ltd | Other services | 2024 |
| SCA Solutions Ltd | Information & communication | 2024 |
| Scaffst Ltd | Construction | 2024 |
| Scalar Systems Limited | Construction | 2018 |
| Scale FB Ltd | Professional & scientific | 2023 |
| Scalegrind Ltd | Other services | 2024 |
| Scanaro Ltd | Information & communication | 2026 |
| Scania (Great Britain) Limited | Wholesale & retail | 1964 |
| Scania BUS and Coach UK Limited | Wholesale & retail | 1982 |
| Scania Properties Limited | Real estate | 1967 |
| Scania Real Estate (UK) Limited | Real estate | 2011 |
| Scanlan Media Ltd | Information & communication | 2023 |
| Scanlink Limited | Wholesale & retail | 1973 |
| Scanmyseo Ltd | Information & communication | 2026 |
| Scantruck Limited | Wholesale & retail | 1986 |
| Scarlat Ltd | Transport & logistics | 2026 |
| Scarlet Gold Limited | Information & communication | 2018 |
| Scarlett Design Limited | Professional & scientific | 1997 |
| SCB Aviation Limited | Manufacturing | 2023 |
| SCC Classics Limited | Wholesale & retail | 2007 |
| SCC Coatings Limited | Manufacturing | 2008 |
| SCC Projects Limited | Administrative & support | 2015 |
| SCC Resources Limited | Administrative & support | 2015 |
| Scci Limited | Professional & scientific | 2004 |
| Scenery Solutions Limited | Construction | 2007 |
| Scenik Limited | Other services | 2022 |
| Scentdrop Ltd | Wholesale & retail | 2026 |
| Scentz UK Fragrances Ltd | Wholesale & retail | 2024 |
| Sces (Smart Cloud Energy Storage) Ltd | Other services | 2023 |
| SCF Outreach Ltd | Hospitality | 2013 |
| Scgf Services Limited | Administrative & support | 2014 |
| Schaeff & Co (UK) | | 1995 |
| Schmoftware Limited | Wholesale & retail | 2022 |
| Scholte Development Ltd | Professional & scientific | 2025 |
| School of Thought 2000 Limited | Professional & scientific | 2005 |
| Schueco UK Limited | Wholesale & retail | 2009 |
| Schunk Intec Ltd. | Manufacturing | 1998 |
| Schwitters Associates Ltd | Professional & scientific | 2023 |
| Schwitters Property Group Ltd | Real estate | 2025 |
| SCI Check Limited | Wholesale & retail | 2009 |
| Science Digits Hub Ltd | Professional & scientific | 2018 |
| Science in Balance Ltd | Information & communication | 2025 |
| Sciencedata Limited | Information & communication | 2016 |
| Scientia UK Limited | Information & communication | 2005 |
| Scientific Glass Manufacturing (U.K.) Limited | Professional & scientific | 1982 |
| Scientis Search Ltd | Administrative & support | 2019 |
| Scipio Consultancy Ltd | Information & communication | 2025 |