| Sourcingmadesimple Ltd | Real estate | 2025 |
| South Asian Catering Limited | Hospitality | 2025 |
| South Cheshire Hearing and Balance Ltd | Manufacturing | 2024 |
| South Haven Property Limited | Real estate | 2016 |
| South Parade Ventures Ltd | Wholesale & retail | 2026 |
| South Pier Media Ltd | Information & communication | 2021 |
| South Western Federation of Museums and Art Galleries | Arts & recreation | 2005 |
| Southall Billing Ltd | Wholesale & retail | 2024 |
| Southampton Private Hire Ltd | Transport & logistics | 2023 |
| Southern Creative Futures Ltd | Information & communication | 2015 |
| Southern Development and Lettings Limited | Real estate | 2017 |
| Southern Liquidation UK Ltd | Wholesale & retail | 2025 |
| Sovereign Legacy Ltd | Arts & recreation | 2025 |
| SOZ Global Limited | Wholesale & retail | 2023 |
| SP Direct Commerce Limited | Wholesale & retail | 2026 |
| SP Print Solutions Limited | Manufacturing | 2024 |
| SP Structural Engineering Ltd | Professional & scientific | 2023 |
| Spai Technologies Ltd | Information & communication | 2025 |
| Spanish Wills Ltd | Professional & scientific | 2025 |
| Spare Safekey Ltd | Other services | 2025 |
| Spares Mountain Ltd | Wholesale & retail | 2024 |
| Spark Competitions Ltd | Arts & recreation | 2023 |
| Spark Healthcare (Diagnostics and Mental Health Sales Marketing) Ltd | Professional & scientific | 2023 |
| Spark Nest Cleaning Ltd | Administrative & support | 2025 |
| Spark Terra Ltd | Wholesale & retail | 2026 |
| Spark Wise Creations Ltd | Wholesale & retail | 2025 |
| Sparkcove Ltd | Wholesale & retail | 2025 |
| Sparkle Hub Solutions Ltd | Professional & scientific | 2024 |
| Sparkle- J Ltd | Wholesale & retail | 2025 |
| Sparklecollect Ltd | Manufacturing | 2025 |
| Spatial Motion Innovations Ltd | Professional & scientific | 2025 |
| SPB Pubs Ltd | Hospitality | 2025 |
| Speak UP Learning Ltd | Education | 2025 |
| SPEAK2 IT Ltd | Information & communication | 2022 |
| Specialist Glass Repairs North Wales Ltd. | Wholesale & retail | 2018 |
| Specialist Souvenirs Limited | Wholesale & retail | 2025 |
| Spectraglass Limited | Manufacturing | 1983 |
| Spectrex LLP | | 2005 |
| Spectrum Repertory Ltd | Arts & recreation | 2022 |
| Speed LK Ltd | Wholesale & retail | 2025 |
| Speed Technology Ltd | Professional & scientific | 2026 |
| Speedy Wordsmith Limited | Arts & recreation | 2024 |
| Spellgroove Limited | Wholesale & retail | 2026 |
| Spence Safety Ltd | Professional & scientific | 2022 |
| Spencer Garages Ltd | Extraterritorial | 2025 |
| Spenny Ltd | Other services | 2016 |
| Spensit Ltd | Information & communication | 2026 |
| Sphere Origins Limited | Information & communication | 2006 |
| Spherical System Ltd | Administrative & support | 2023 |
| Sphinx Trade Ltd | Wholesale & retail | 2025 |
| Spirit Seven Music Ltd. | Information & communication | 2015 |
| Spirit Therapy Ltd | Extraterritorial | 2006 |
| Spitfire Radio C.I.C. | Information & communication | 2023 |
| Spjc Ltd | Wholesale & retail | 2018 |
| SPK Property Holdings Limited | Real estate | 2022 |
| Splendor Chapter UK Ltd | Wholesale & retail | 2025 |
| Split Garments Ltd | Wholesale & retail | 2026 |
| Splus Consulting Limited | Professional & scientific | 2025 |
| Sport Star Media Ltd | Information & communication | 2025 |
| Sportykit Ltd | Professional & scientific | 2025 |
| Spotlight Happy Ltd | Wholesale & retail | 2025 |
| Springland Ltd | Wholesale & retail | 2023 |
| Spruce UP Ltd | Administrative & support | 2026 |
| Spryte Omega Dominion Ltd | Arts & recreation | 2025 |
| SPV Newbury One Limited | Real estate | 2022 |
| SQU Property Ltd | Real estate | 2025 |
| Square Sea Art Studio Ltd | Wholesale & retail | 2024 |
| Squires Programme Management Services Limited | Information & communication | 2025 |
| Sqwad Limited | Information & communication | 2025 |
| SR Moto Ltd | Manufacturing | 2023 |
| SR Stays Limited | Real estate | 2024 |
| Srbdrivingconcierge Ltd | Professional & scientific | 2025 |
| Srboe Development Limited | Real estate | 2024 |
| SRI Lanka Explores Ltd | Administrative & support | 2023 |
| SRW Accountants Limited | Professional & scientific | 2013 |
| SSA Services Group Ltd | Administrative & support | 2017 |
| ST Andrews Court (Mildenhall) Management Company Limited | Real estate | 2004 |
| ST Francis Investments Ltd | Extraterritorial | 2013 |
| ST IT Consultancy Limited | Information & communication | 2024 |
| ST Real Estate Partners Limited | Real estate | 2024 |
| ST42 Ltd | Information & communication | 2026 |
| Stage Left Drama and Music School Ltd | Education | 2025 |
| Staged Theatre Ltd | Arts & recreation | 2026 |
| Staged to Go Ltd | Administrative & support | 2024 |
| Stageform Ltd | Information & communication | 2026 |
| Stainless London Limited | Administrative & support | 2020 |
| Stalliondc Ltd | Wholesale & retail | 2021 |
| Standfast Advisory Ltd | Administrative & support | 2022 |
| Standout Brickwork Ltd | Construction | 2023 |
| Stanknetic Ltd | Information & communication | 2025 |
| Stanlake Estates Ltd | Real estate | 2024 |
| Stanley Investment Group Ltd | Financial services | 2023 |
| Stanoi Limited | Professional & scientific | 2019 |
| Star Choosing Limited | Wholesale & retail | 2025 |
| Star Footballer Ltd | Arts & recreation | 2025 |
| Star Heart Jewellery Ltd | Manufacturing | 2025 |
| Star Isle Crossborder Limited | Wholesale & retail | 2026 |
| Starang Ltd | Health & social care | 2023 |
| Stardust Europe Limited | Financial services | 2005 |
| Starfire Software Ltd | Information & communication | 2023 |