| South Cheshire House Clearances Limited | Administrative & support | 2004 |
| SP 54 Ltd | Hospitality | 2022 |
| Spanset Limited | Manufacturing | 1969 |
| Specialist POS & Display Ltd | Professional & scientific | 2024 |
| Sports Coaching Congleton Limited | Education | 2020 |
| Sports Coaching Crewe Limited | Arts & recreation | 2012 |
| Sports Coaching Group Limited | Education | 2011 |
| Sports Coaching Macclesfield Limited | Education | 2020 |
| Sports Coaching Nantwich Limited | Arts & recreation | 2007 |
| Sports Coaching Sandbach Limited | Education | 2020 |
| Sportscape Education Ltd | Arts & recreation | 2011 |
| Springle Projects Limited | Other services | 2016 |
| SR Sports Ltd | Arts & recreation | 2021 |
| Ssas Accountants Limited | Professional & scientific | 2020 |
| Stanthorne Legal Services Limited | Professional & scientific | 2020 |
| Stclair Home Improvements (Cheshire) Limited | Construction | 2017 |
| Stephen Blackburn Associates Ltd | Education | 2013 |
| Streat Food Take Away Limited | Hospitality | 2021 |
| Stuart Newman Food Technical & Quality Services Limited | Professional & scientific | 2016 |
| Stylish-Spaces Ltd | Wholesale & retail | 2025 |
| Supastrikers Warrington Limited | Education | 2021 |
| Super Bargains Middlewich Limited | Wholesale & retail | 2026 |
| Sweets & Treats Middlewich Ltd | Wholesale & retail | 2024 |
| Systematic Evaluations Limited | Administrative & support | 2021 |
| T C Whittaker Limited | Construction | 2013 |
| T.Lea Sherwin Limited | Agriculture & fishing | 1961 |
| Tait Construction Consultants Ltd | Administrative & support | 2021 |
| Tankless Water Solutions Limited | Wholesale & retail | 2023 |
| TAY Brew Co Ltd | Manufacturing | 2023 |
| TBB Choice Ltd | Wholesale & retail | 2025 |
| Tech Excess Ltd | Wholesale & retail | 2017 |
| Tentha Care Ltd | Education | 2023 |
| TFF Greenacres Holdings Limited | Financial services | 2021 |
| Thackham Carpets and Flooring Limited | Wholesale & retail | 2018 |
| THE Alpine Adventure Group Ltd | Wholesale & retail | 2026 |
| THE Cheshire Garage Door Company Ltd | Construction | 2025 |
| THE Cheshire Lawn Care Company EST 2009 Limited | Administrative & support | 2025 |
| THE Craft Cabin at Hopley Ltd | Wholesale & retail | 2023 |
| THE Dutton Holding Company Limited | Construction | 2011 |
| THE EPC HUT Limited | Other services | 2010 |
| THE Floor Studio Cheshire Ltd | Construction | 2020 |
| THE Gifty Chick Ltd | Wholesale & retail | 2024 |
| THE Golden Lion (Middlewich) Limited | Hospitality | 2010 |
| THE Golden Lion Hotel ( Middlewich ) Limited | Hospitality | 2012 |
| THE Golden Lion Lodge Limited | Hospitality | 2017 |
| THE Jason Group Limited | Manufacturing | 2005 |
| THE John Hulme Partnership Limited | Information & communication | 2005 |
| THE KC Consultancy Group Limited | Administrative & support | 2022 |
| THE Little Hope Project CIC | Health & social care | 2025 |
| THE Little Nursery Group Limited | Education | 2012 |
| THE Mayday Services Group Limited | Construction | 2022 |
| THE Middlewich Lodge Limited | Hospitality | 2014 |
| THE Northwich Boat Company Limited | Manufacturing | 2004 |
| THE Old Hough Fishery Ltd | Agriculture & fishing | 2024 |
| THE Old Hough Holdings Ltd | Financial services | 2024 |
| THE Pink Beauty Co Ltd | Other services | 2021 |
| THE Rural Business Group Ltd | Financial services | 2024 |
| THE Tipsy Trolley Ltd | Hospitality | 2025 |
| THE Travel Lounge Middlewich Limited | Administrative & support | 2013 |
| THE Turnpike (Middlewich) Ltd | Professional & scientific | 2020 |
| THE Weavers (Block 10) RTM Company Limited | Households | 2024 |
| THE Weavers (Block 11) RTM Company Limited | Households | 2024 |
| THE Weavers (Block 12) RTM Company Limited | Households | 2024 |
| THE Weavers (Block 14) RTM Company Limited | Households | 2024 |
| THE Weavers (Block 3) RTM Company Limited | Households | 2024 |
| THE Weavers (Block 4) RTM Company Limited | Households | 2024 |
| THE Weavers (Block 7) RTM Limited | Households | 2024 |
| THE Weavers (Block 8) RTM Company Limited | Households | 2024 |
| THE Weavers (Block 9) RTM Company Limited | Households | 2024 |
| THE Weavers (BLOCK1) RTM Company Limited | Households | 2024 |
| THE Weavers (BLOCK2) RTM Company Limited | Households | 2024 |
| THE Weavers (BLOCK5) RTM Company Limited | Households | 2024 |
| THE Woodlands Shareholding Ltd | Financial services | 2017 |
| THE Write Copy Girl Limited | Professional & scientific | 2017 |
| Theron Refractories Consultancy Ltd | Professional & scientific | 2025 |
| Third Sector First Limited | Professional & scientific | 1998 |
| Thompstone Holdings Limited | Administrative & support | 2007 |
| Titan Electrical Services Limited | Construction | 2006 |
| Titanium Financial Options Limited | Financial services | 2023 |
| TJ Electrical Cheshire Ltd | Construction | 2022 |
| TLZ Tech Ltd | Professional & scientific | 2016 |
| TNS Autos Limited | Wholesale & retail | 2015 |
| TOM Brown Catering Ltd | Hospitality | 2013 |
| TOM Hough Limited | Professional & scientific | 1955 |
| Top Style UK Roofing Specialists Ltd | Construction | 2025 |
| Total Industrial Solutions Limited | Administrative & support | 2025 |
| Touch of Grace, Cheshire Limited | Wholesale & retail | 2020 |
| Townbridge Estate Agents Limited | Real estate | 2010 |
| Townbridge Residential Surveys Limited | Professional & scientific | 2025 |
| Traci Jewellery Limited | Wholesale & retail | 2026 |
| Trans to YOU Ltd | Transport & logistics | 2018 |
| Tree Surgeon Hedge Cutting Services Ltd | Administrative & support | 2025 |
| Treetops Plants & Nurseries Ltd | Agriculture & fishing | 2025 |
| Trojan Holdco Ltd | Financial services | 2026 |
| Trueline Engineering Services Limited | Manufacturing | 1992 |
| Truity Wealth Management Limited | Professional & scientific | 2021 |
| Tsoa Limited | Hospitality | 2025 |
| Turtle Financial Services Ltd | Professional & scientific | 2022 |
| Tuzzi Ltd | Professional & scientific | 2005 |
| TWF Project Management Limited | Professional & scientific | 2018 |