| M J Iddon Contracting Limited | Administrative & support | 2010 |
| M S Construction and SON Limited | Construction | 2017 |
| M. & C. Interiors Limited | Construction | 2003 |
| Maid in Holmes Chapel Limited | Administrative & support | 2023 |
| Mailbox Rental Ltd | Administrative & support | 2021 |
| Manchester Aerial & Acrobatics Convention Limited | Arts & recreation | 2018 |
| Manor Care Home Limited | Health & social care | 2007 |
| Mantraco Landscapes Ltd | Administrative & support | 2022 |
| Marbo International Limited | Wholesale & retail | 2001 |
| Marbocote Limited | Manufacturing | 2001 |
| Maria Car Maintenance Ltd | Wholesale & retail | 2022 |
| Martins of Cheshire Limited | Professional & scientific | 1994 |
| Master Vaper Direct Limited | Wholesale & retail | 2017 |
| Matasha Ltd | Wholesale & retail | 2025 |
| Mcguinness Limited | Hospitality | 2024 |
| MCR Labs Ltd | Information & communication | 2026 |
| Mdcw Ltd | Professional & scientific | 2018 |
| Meadowcroft Farm MAN Co Limited | Real estate | 2024 |
| Megavolt Limited | Professional & scientific | 2010 |
| Mercury Lifts Ltd | Manufacturing | 2024 |
| Meridian Tech Limited | Professional & scientific | 2025 |
| MID Cheshire Motor Racing Club Limited(The) | Arts & recreation | 1953 |
| MID Cheshire Scaffolding Limited | Construction | 2010 |
| Middlewich Autos Limited | Wholesale & retail | 1990 |
| Middlewich Barbers Ltd | Other services | 2025 |
| Middlewich Canal Centre Limited | Manufacturing | 2018 |
| Middlewich D.I.Y. Centre Ltd | Wholesale & retail | 2015 |
| Middlewich Fencing Contractors Ltd | Administrative & support | 2021 |
| Middlewich Heritage Trust | Education | 2015 |
| Middlewich Kebab Ltd | Hospitality | 2025 |
| Middlewich Machinery Hire Limited | Administrative & support | 2026 |
| Middlewich Machinery Limited | Manufacturing | 2024 |
| Middlewich MOT Centre Limited | Wholesale & retail | 2003 |
| Middlewich Narrowboat Painting LLP | | 2026 |
| Middlewich Narrowboat Services LLP | | 2025 |
| Middlewich News Limited | Wholesale & retail | 2019 |
| Middlewich Tank Wash Limited | Administrative & support | 1994 |
| Middlewich TAP House Limited | Hospitality | 2016 |
| Middlewich Town Football Club CIC | Arts & recreation | 2026 |
| Mike Barrett Construction Limited | Construction | 2011 |
| Miles More Media Limited | Information & communication | 2018 |
| Milestone PUB Company Limited | Hospitality | 2011 |
| Millennium Marquees Limited | Other services | 1997 |
| Mind Fuelled Mini's Ltd | Manufacturing | 2026 |
| Mistry Medical Supplies Limited | Wholesale & retail | 2007 |
| Mitchell Building and IND. Groundworks Limited | Construction | 2010 |
| MJ Industrial Solutions Limited | Wholesale & retail | 2022 |
| MJM Ltd | Real estate | 2017 |
| Mjrlb Ltd | Information & communication | 2023 |
| Modus Pre-Fabricated Extensions Ltd | Construction | 2025 |
| Moorsbarrow Hall Farm Ltd | Agriculture & fishing | 2023 |
| Moreton Contractors Limited | Construction | 2007 |
| Morris and Sons Group Limited | Information & communication | 2026 |
| Moss Consultants Limited | Professional & scientific | 2024 |
| MOTORS4CASH/RHYL Ltd | Wholesale & retail | 2019 |
| Move Consulting Ltd | Professional & scientific | 2020 |
| Move Training Ltd | Education | 2022 |
| MOW IT ALL Limited | Administrative & support | 2009 |
| MST Group Holdings Limited | Financial services | 2021 |
| Munroe Roofing Ltd | Construction | 2026 |
| N Jones Design Ltd | Professional & scientific | 2018 |
| Navaro Digital Limited | Information & communication | 2026 |
| NBR Business Solutions Ltd | Professional & scientific | 2016 |
| NCS HR Solutions Limited | Professional & scientific | 2024 |
| Neil Hopley Electrical Contractors Limited | Construction | 2003 |
| New Wizard Holdings Limited | Financial services | 2020 |
| Newfield Trust Services Ltd | Professional & scientific | 2002 |
| Niblett Construction Ltd | Construction | 2022 |
| Niblett Homes Ltd | Real estate | 2018 |
| Nixon Plant Ltd | Construction | 2024 |
| NJT Composites Limited | Manufacturing | 2023 |
| Noemi James Management Ltd | Professional & scientific | 2026 |
| Noonan Performance Limited | Other services | 2019 |
| North Pole South Pole Ltd | Other services | 2022 |
| Northern Backdrop Limited | Administrative & support | 2012 |
| Northern Brewer Limited | Real estate | 2014 |
| Northern Corrugated Cases Limited | Manufacturing | 1987 |
| Northwest Roofing and Guttering Ltd | Construction | 2024 |
| Northwood (Holdings) Limited | Financial services | 2011 |
| Northwood Computer Services Limited | Manufacturing | 2002 |
| NRJ Engineering Services Limited | Construction | 2015 |
| NS Cheshire Holdings Limited | Transport & logistics | 2020 |
| Nurturing Skills Ltd | Professional & scientific | 2012 |
| Oak Leaf Laser Etchings Limited | Professional & scientific | 2026 |
| Obscura Creative Ltd. | Professional & scientific | 2018 |
| Old Hough Caravan Storage Ltd | Transport & logistics | 2024 |
| Oligomer Accounting Services Ltd | Professional & scientific | 2010 |
| Oliver Perry Ltd | Wholesale & retail | 2019 |
| Olivia Catton Eventing Ltd | Arts & recreation | 2013 |
| ON Newco Limited | Other services | 2017 |
| Onfab Limited | Manufacturing | 2009 |
| Oomph Consultancy Limited | Professional & scientific | 2013 |
| Optima Logistics Limited | Transport & logistics | 2010 |
| Opus Electrical Solutions Limited | Construction | 2016 |
| Orchards Property & Gardens Ltd | Real estate | 2025 |
| Orez Distribution Limited | Wholesale & retail | 2024 |
| Ownashare Cruising Limited | Manufacturing | 2010 |
| P & H Evans Limited | Wholesale & retail | 2020 |
| P Welsh Holdings Ltd | Real estate | 2019 |
| P.B.S. Properties Limited | Construction | 1987 |