| SAM Property Assets Ltd | Real estate | 2026 |
| SAM Wholesale Trading Ltd | Wholesale & retail | 2003 |
| Sam's Fade Studio Ltd | Other services | 2025 |
| Sam's Service and Maintenance Limited | Construction | 2014 |
| Sam-Engg Ltd | Professional & scientific | 2025 |
| Samantha Jane Hairdressing Ltd | Other services | 2025 |
| Samico Transport and Logistics Ltd | Wholesale & retail | 2024 |
| Samir Calin Logistics Limited | Transport & logistics | 2025 |
| SAMMIEDRURY1 Ltd | Wholesale & retail | 2025 |
| Samos CCP Ltd. | Professional & scientific | 2017 |
| Samrawit Ltd | Transport & logistics | 2026 |
| Samson 5G Utilities Ltd | Construction | 2023 |
| Samson Travel Logistics Ltd | Transport & logistics | 2025 |
| Samuel J F Bilton Ltd | Professional & scientific | 2025 |
| Samy (County) Limited | Wholesale & retail | 2023 |
| Samy (March) Limited | Wholesale & retail | 2023 |
| Samy Group Ltd | Financial services | 2025 |
| Samy Investments Ltd | Wholesale & retail | 2019 |
| Samy Limited | Wholesale & retail | 2011 |
| Samy Services Ltd | Wholesale & retail | 2025 |
| Samyquality Ltd | Health & social care | 2018 |
| Sanaum Locum Ltd | Health & social care | 2014 |
| Sand Dancer Holdings Limited | Administrative & support | 2020 |
| Sand Dune Ltd | Real estate | 2023 |
| Sand Dune Properties Ltd | Real estate | 2023 |
| Sanderson Groundcare Ltd | Administrative & support | 2014 |
| Sandmartin Financial Services Limited | Financial services | 2018 |
| Sanhak Ltd | Manufacturing | 2018 |
| Sankuri Construction Limited | Construction | 2026 |
| Sanset Solutions Ltd | Wholesale & retail | 2019 |
| Santuo Homes Ltd | Real estate | 2026 |
| Saoirse Capital Limited | Financial services | 2018 |
| SAP Mcelwee Properties Ltd | Real estate | 2026 |
| Sapper Transport Ltd | Transport & logistics | 2020 |
| Sapphire Letting (NE) Limited | Real estate | 2024 |
| Sapphire Print Solutions Limited | Wholesale & retail | 2013 |
| Sapphire West Ltd | Professional & scientific | 2023 |
| Saproduct (UK) Limited | Information & communication | 2013 |
| Saqu Ltd | Other services | 2025 |
| Sarabec Limited | Manufacturing | 1987 |
| Sarens (UK) Ltd | Construction | 1988 |
| Sark Co. Limited | Real estate | 1990 |
| Sarnico Properties Ltd | Real estate | 2017 |
| Saron Real Estate UK Limited | Real estate | 2025 |
| SAS (NE) Ltd | Manufacturing | 2025 |
| Sass Media Ltd | Information & communication | 2022 |
| Satinfire Limited | Information & communication | 2020 |
| Satori Aesthetics Ltd | Other services | 2016 |
| Saturn Turbo Services Ltd | Administrative & support | 2021 |
| Satyajeet Sampat Patil Ltd | Transport & logistics | 2026 |
| Sauce Marketing Group Ltd | Information & communication | 2025 |
| Saunters Limited | Administrative & support | 2026 |
| Savage Bunny Studios Ltd | Arts & recreation | 2024 |
| Savak Limited | Administrative & support | 2013 |
| Savak Property Limited | Real estate | 2018 |
| Save the Woman | Other services | 2018 |
| Savtech Solutions Limited | Manufacturing | 2017 |
| SAW NE Ltd | Real estate | 2025 |
| Sawdust Workshop CIC | Arts & recreation | 2025 |
| Saweeeties Ltd | Hospitality | 2025 |
| Sayer Property Investment (NE) Ltd | Real estate | 2022 |
| SB Crushing Limited | Construction | 2016 |
| SB Noble Ltd | Professional & scientific | 2024 |
| SB Optics Ltd | Professional & scientific | 2017 |
| SB Wind Solutions Limited | Construction | 2016 |
| SBH Engineering Services Ltd | Professional & scientific | 2016 |
| Sbis (Corporate) Ltd | Health & social care | 2026 |
| SBR Compliance Ltd | Construction | 2025 |
| SC Daniels Logistics Ltd | Transport & logistics | 2025 |
| SC Mechanical Services Ltd | Professional & scientific | 2026 |
| SC Portfolio 1 Limited | Professional & scientific | 2019 |
| SC Portfolio 2 Limited | Information & communication | 2015 |
| SC Portfolio 3 Limited | Administrative & support | 2020 |
| SC Portfolio 4 Limited | Administrative & support | 2020 |
| SC Portfolio 5 Limited | Information & communication | 2021 |
| SC Portfolio 6 Limited | Information & communication | 2019 |
| SC Quality Consultancy Services Limited | Professional & scientific | 2015 |
| Scaff 77 Limited | Construction | 2025 |
| Scaffhub Limited | Construction | 2024 |
| Scaffold Innovators Ltd | Construction | 2026 |
| Scaled Engineering Limited | Professional & scientific | 2019 |
| Scan My Baby Ltd | Health & social care | 2017 |
| Scanman UK Limited | Manufacturing | 2010 |
| Scanr Events Ltd | Wholesale & retail | 2025 |
| Scarlette Rose Limited | Health & social care | 2016 |
| SCD Ltd | Construction | 2024 |
| Scentz Wholesale Ltd | Wholesale & retail | 2019 |
| Sceptre Coaching Ltd | Education | 2024 |
| School of Further Studies Ltd | Education | 2022 |
| Scmc Properties Limited | Real estate | 2023 |
| Scope Coatings Ltd | Construction | 2023 |
| Scope Hire Limited | Other services | 2021 |
| Score.Vision Limited | Information & communication | 2019 |
| Scorpio Tattoo Artist Ltd | Administrative & support | 2003 |
| Scotfir Ltd | Manufacturing | 2003 |
| Scott Rigging & Lifting Services Ltd | Professional & scientific | 2014 |
| Scott Taylor Law Limited | Professional & scientific | 2017 |
| Scott's Industrial Solutions Ltd | Professional & scientific | 2021 |
| Scotts Jewellers Ltd | Wholesale & retail | 2026 |
| Scotty Barber Lounge Ltd | Other services | 2024 |